GPR137B G protein-coupled receptor 137B [Homo sapiens (human)] - Gene

Summary

Official Symbol: GPR137Bprovided by HGNC
Official Full Name: G protein-coupled receptor 137Bprovided by HGNC
Primary source: HGNC:HGNC:11862
See related: Ensembl:ENSG00000077585 MIM:604658; AllianceGenome:HGNC:11862
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TM7SF1
Summary: Involved in positive regulation of TORC1 signaling; positive regulation of protein localization to lysosome; and regulation of autophagy. Located in lysosomal membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in kidney (RPKM 12.9), brain (RPKM 8.4) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q42.3

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (236142539..236208907)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (235544639..235611151)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (236305839..236372207)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PR137B-knockout cells exhibited defective autophagy and an expanded lysosome compartment, similar to Rag-knockout cells. Like zebrafish RagA mutants, GPR137B-mutant zebrafish had upregulated TFEB target gene expression and an expanded lysosome compartment in microglia.
Title: The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1 localization and activity.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G54147 (e-PCR)
- UniSTS:109384

SHGC-63657 (e-PCR)
- UniSTS:33123

SHGC-76532 (e-PCR)
- UniSTS:1393

SHGC-64303 (e-PCR)
- UniSTS:40341

SHGC-76568 (e-PCR)
- UniSTS:76967

RH76461 (e-PCR)
- UniSTS:91087

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of bone resorption	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of bone resorption	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of osteoclast differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of osteoclast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of TORC1 signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to lysosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of autophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of macrophage activation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	TAS Traceable Author Statement more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: integral membrane protein GPR137B

Names: transmembrane 7 superfamily member 1 (upregulated in kidney); transmembrane 7 superfamily member 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_003272.4 → NP_003263.1 integral membrane protein GPR137B

See identical proteins and their annotated locations for NP_003263.1

Status: VALIDATED

Source sequence(s)

AI634648, BC012100

Consensus CDS

CCDS1609.1

UniProtKB/Swiss-Prot

O60478, Q53EK7, Q5TAE6, Q6FHI3

UniProtKB/TrEMBL

B2R7A7

Related

ENSP00000355551.3, ENST00000366592.8

Conserved Domains (1) summary

cd21476
Location:35 → 354

7tm_GPR137B; Integral membrane protein GPR137B, an orphan receptor member of the seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

236142539..236208907

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017002209.3 → XP_016857698.1 integral membrane protein GPR137B isoform X1

UniProtKB/TrEMBL

B2R7A7

Conserved Domains (1) summary

TIGR03022
Location:80 → 191

WbaP_sugtrans; Undecaprenyl-phosphate galactose phosphotransferase, WbaP