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    ZBTB21 zinc finger and BTB domain containing 21 [ Homo sapiens (human) ]

    Gene ID: 49854, updated on 10-Dec-2024

    Summary

    Official Symbol
    ZBTB21provided by HGNC
    Official Full Name
    zinc finger and BTB domain containing 21provided by HGNC
    Primary source
    HGNC:HGNC:13083
    See related
    Ensembl:ENSG00000173276 MIM:616485; AllianceGenome:HGNC:13083
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF295
    Summary
    Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; POZ domain binding activity; and methyl-CpG binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal (RPKM 15.8), gall bladder (RPKM 5.4) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZBTB21 in Genome Data Viewer
    Location:
    21q22.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (41986831..42010360, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (40377057..40400598, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (43406940..43430469, complement)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18485 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr21:43241376-43242575 Neighboring gene PR/SET domain 15 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18486 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18487 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:43256373-43257080 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr21:43274198-43275397 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18488 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18489 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18490 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18491 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18492 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13333 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18493 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43318691-43319691 Neighboring gene C2 calcium dependent domain containing 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18494 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18495 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18496 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43364315-43364815 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43370715-43371220 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:43373099-43373873 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18497 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43378985-43379952 Neighboring gene NANOG hESC enhancer GRCh37_chr21:43388567-43389068 Neighboring gene small nucleolar RNA, H/ACA box 91 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:43415728-43415930 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13335 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13336 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13337 Neighboring gene ZNF295 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18498 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43460101-43460604 Neighboring gene uncharacterized LOC107985502 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43461111-43461614 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43463997-43464496 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43479981-43480564 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43480565-43481148 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18499 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18500 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18501 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18502 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:43487460-43488014 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43492613-43493114 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43493115-43493614 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43495709-43496210 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43496211-43496710 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:43501841-43502776 Neighboring gene uromodulin like 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43513487-43513992 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43523509-43524067 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43524068-43524625 Neighboring gene Sharpr-MPRA regulatory region 15350 Neighboring gene UMODL1 antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp781N1974

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables POZ domain binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables methyl-CpG binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    zinc finger and BTB domain-containing protein 21
    Names
    zinc finger protein 295

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098402.2NP_001091872.1  zinc finger and BTB domain-containing protein 21 isoform L

      See identical proteins and their annotated locations for NP_001091872.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) contains an alternate exon in the 5' UTR compared to variant 5. Variants 1, 2, and 5 encode the longer isoform (L).
      Source sequence(s)
      AB041014, BP230048
      Consensus CDS
      CCDS13678.1
      UniProtKB/Swiss-Prot
      Q5R2W1, Q5R2W2, Q6P4R0, Q9ULJ3
      Related
      ENSP00000308759.5, ENST00000310826.10
      Conserved Domains (6) summary
      sd00017
      Location:548569
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:911931
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18209
      Location:12123
      BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
      pfam00096
      Location:670692
      zf-C2H2; Zinc finger, C2H2 type
      pfam18450
      Location:746773
      zf_C2H2_6; Zinc Finger domain
      cd20908
      Location:545598
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
    2. NM_001098403.2NP_001091873.1  zinc finger and BTB domain-containing protein 21 isoform S

      See identical proteins and their annotated locations for NP_001091873.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an in-frame segment in the coding region compared to variant 5. Variants 3 and 4 encode isoform S, which is shorter than isoform L.
      Source sequence(s)
      AB041015, BP230048
      Consensus CDS
      CCDS42934.1
      UniProtKB/Swiss-Prot
      Q9ULJ3
      Related
      ENSP00000381517.3, ENST00000398505.7
      Conserved Domains (3) summary
      smart00225
      Location:31120
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00019
      Location:710730
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:20120
      BTB; BTB/POZ domain
    3. NM_001320729.2NP_001307658.1  zinc finger and BTB domain-containing protein 21 isoform S

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame segment in the coding region compared to variant 1. Variants 3 and 4 encode isoform S, which is shorter than isoform L.
      Source sequence(s)
      AB041015, BC063290, BP230048
      Consensus CDS
      CCDS42934.1
      UniProtKB/Swiss-Prot
      Q9ULJ3
      Conserved Domains (3) summary
      smart00225
      Location:31120
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00019
      Location:710730
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:20120
      BTB; BTB/POZ domain
    4. NM_001320731.2NP_001307660.1  zinc finger and BTB domain-containing protein 21 isoform L

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) represents the longest transcript. Variants 1, 2, and 5 encode the longer isoform (L).
      Source sequence(s)
      AB041014, AB041015, AJ003669, BC063290, CR933655
      Consensus CDS
      CCDS13678.1
      UniProtKB/Swiss-Prot
      Q5R2W1, Q5R2W2, Q6P4R0, Q9ULJ3
      Related
      ENSP00000381512.1, ENST00000398499.5
      Conserved Domains (6) summary
      sd00017
      Location:548569
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:911931
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18209
      Location:12123
      BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
      pfam00096
      Location:670692
      zf-C2H2; Zinc finger, C2H2 type
      pfam18450
      Location:746773
      zf_C2H2_6; Zinc Finger domain
      cd20908
      Location:545598
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
    5. NM_020727.5NP_065778.3  zinc finger and BTB domain-containing protein 21 isoform L

      See identical proteins and their annotated locations for NP_065778.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains two alternate exons in the 5' UTR compared to variant 5. Variants 1, 2, and 5 encode the longer isoform (L).
      Source sequence(s)
      AB041014, BC063290, BP230048
      Consensus CDS
      CCDS13678.1
      UniProtKB/Swiss-Prot
      Q5R2W1, Q5R2W2, Q6P4R0, Q9ULJ3
      Related
      ENSP00000381523.3, ENST00000398511.3
      Conserved Domains (6) summary
      sd00017
      Location:548569
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:911931
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18209
      Location:12123
      BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
      pfam00096
      Location:670692
      zf-C2H2; Zinc finger, C2H2 type
      pfam18450
      Location:746773
      zf_C2H2_6; Zinc Finger domain
      cd20908
      Location:545598
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

      Range
      41986831..42010360 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047440793.1XP_047296749.1  zinc finger and BTB domain-containing protein 21 isoform X2

    2. XM_011529588.3XP_011527890.1  zinc finger and BTB domain-containing protein 21 isoform X1

      See identical proteins and their annotated locations for XP_011527890.1

      UniProtKB/Swiss-Prot
      Q5R2W1, Q5R2W2, Q6P4R0, Q9ULJ3
      Conserved Domains (6) summary
      sd00017
      Location:548569
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:911931
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18209
      Location:12123
      BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
      pfam00096
      Location:670692
      zf-C2H2; Zinc finger, C2H2 type
      pfam18450
      Location:746773
      zf_C2H2_6; Zinc Finger domain
      cd20908
      Location:545598
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
    3. XM_047440788.1XP_047296744.1  zinc finger and BTB domain-containing protein 21 isoform X1

      UniProtKB/Swiss-Prot
      Q5R2W1, Q5R2W2, Q6P4R0, Q9ULJ3
    4. XM_047440792.1XP_047296748.1  zinc finger and BTB domain-containing protein 21 isoform X2

    5. XM_017028360.2XP_016883849.1  zinc finger and BTB domain-containing protein 21 isoform X1

      UniProtKB/Swiss-Prot
      Q5R2W1, Q5R2W2, Q6P4R0, Q9ULJ3
      Conserved Domains (6) summary
      sd00017
      Location:548569
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:911931
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18209
      Location:12123
      BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
      pfam00096
      Location:670692
      zf-C2H2; Zinc finger, C2H2 type
      pfam18450
      Location:746773
      zf_C2H2_6; Zinc Finger domain
      cd20908
      Location:545598
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
    6. XM_047440794.1XP_047296750.1  zinc finger and BTB domain-containing protein 21 isoform X2

    7. XM_047440786.1XP_047296742.1  zinc finger and BTB domain-containing protein 21 isoform X1

      UniProtKB/Swiss-Prot
      Q5R2W1, Q5R2W2, Q6P4R0, Q9ULJ3
    8. XM_047440795.1XP_047296751.1  zinc finger and BTB domain-containing protein 21 isoform X2

    9. XM_047440790.1XP_047296746.1  zinc finger and BTB domain-containing protein 21 isoform X1

      UniProtKB/Swiss-Prot
      Q5R2W1, Q5R2W2, Q6P4R0, Q9ULJ3
    10. XM_047440787.1XP_047296743.1  zinc finger and BTB domain-containing protein 21 isoform X1

      UniProtKB/Swiss-Prot
      Q5R2W1, Q5R2W2, Q6P4R0, Q9ULJ3
    11. XM_047440796.1XP_047296752.1  zinc finger and BTB domain-containing protein 21 isoform X2

    12. XM_047440791.1XP_047296747.1  zinc finger and BTB domain-containing protein 21 isoform X1

      UniProtKB/Swiss-Prot
      Q5R2W1, Q5R2W2, Q6P4R0, Q9ULJ3
    13. XM_005261121.4XP_005261178.1  zinc finger and BTB domain-containing protein 21 isoform X1

      See identical proteins and their annotated locations for XP_005261178.1

      UniProtKB/Swiss-Prot
      Q5R2W1, Q5R2W2, Q6P4R0, Q9ULJ3
      Conserved Domains (6) summary
      sd00017
      Location:548569
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:911931
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18209
      Location:12123
      BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
      pfam00096
      Location:670692
      zf-C2H2; Zinc finger, C2H2 type
      pfam18450
      Location:746773
      zf_C2H2_6; Zinc Finger domain
      cd20908
      Location:545598
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
    14. XM_047440797.1XP_047296753.1  zinc finger and BTB domain-containing protein 21 isoform X2

    15. XM_047440789.1XP_047296745.1  zinc finger and BTB domain-containing protein 21 isoform X1

      UniProtKB/Swiss-Prot
      Q5R2W1, Q5R2W2, Q6P4R0, Q9ULJ3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060945.1 Alternate T2T-CHM13v2.0

      Range
      40377057..40400598 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054324536.1XP_054180511.1  zinc finger and BTB domain-containing protein 21 isoform X2

    2. XM_054324530.1XP_054180505.1  zinc finger and BTB domain-containing protein 21 isoform X1

    3. XM_054324531.1XP_054180506.1  zinc finger and BTB domain-containing protein 21 isoform X1

    4. XM_054324535.1XP_054180510.1  zinc finger and BTB domain-containing protein 21 isoform X2

    5. XM_054324528.1XP_054180503.1  zinc finger and BTB domain-containing protein 21 isoform X1

    6. XM_054324539.1XP_054180514.1  zinc finger and BTB domain-containing protein 21 isoform X2

    7. XM_054324526.1XP_054180501.1  zinc finger and BTB domain-containing protein 21 isoform X1

    8. XM_054324537.1XP_054180512.1  zinc finger and BTB domain-containing protein 21 isoform X2

    9. XM_054324532.1XP_054180507.1  zinc finger and BTB domain-containing protein 21 isoform X1

    10. XM_054324538.1XP_054180513.1  zinc finger and BTB domain-containing protein 21 isoform X2

    11. XM_054324533.1XP_054180508.1  zinc finger and BTB domain-containing protein 21 isoform X1

    12. XM_054324527.1XP_054180502.1  zinc finger and BTB domain-containing protein 21 isoform X1

    13. XM_054324540.1XP_054180515.1  zinc finger and BTB domain-containing protein 21 isoform X2

    14. XM_054324534.1XP_054180509.1  zinc finger and BTB domain-containing protein 21 isoform X1

    15. XM_054324529.1XP_054180504.1  zinc finger and BTB domain-containing protein 21 isoform X1