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    CLEC2L C-type lectin domain family 2 member L [ Homo sapiens (human) ]

    Gene ID: 154790, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CLEC2Lprovided by HGNC
    Official Full Name
    C-type lectin domain family 2 member Lprovided by HGNC
    Primary source
    HGNC:HGNC:21969
    See related
    Ensembl:ENSG00000236279 AllianceGenome:HGNC:21969
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable carbohydrate binding activity. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in brain (RPKM 5.6), endometrium (RPKM 0.5) and 1 other tissue See more
    Orthologs
    mouse all
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    Genomic context

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    See CLEC2L in Genome Data Viewer
    Location:
    7q34
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (139523685..139544985)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (140836984..140858283)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (139208431..139229731)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:139136252-139137140 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:139137141-139138027 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:139138916-139139802 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:139146664-139147433 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:139150055-139150776 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:139152221-139152942 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:139153665-139154386 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:139154387-139155106 Neighboring gene RNA, U6 small nuclear 911, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:139164565-139165065 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:139164064-139164564 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26761 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18696 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18697 Neighboring gene killer cell lectin like receptor G2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26762 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26763 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:139226381-139227154 Neighboring gene ST13, Hsp70 interacting protein pseudogene 17 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:139229072-139229673 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26764 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:139253336-139253836 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:139253837-139254337 Neighboring gene uncharacterized LOC105375530 Neighboring gene ERH pseudogene 1 Neighboring gene homeodomain interacting protein kinase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26765 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:139311135-139311345 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26766 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18698 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:139365244-139366443 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26767 Neighboring gene NANOG hESC enhancer GRCh37_chr7:139377579-139378080 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:139411674-139412500 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26768 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:139415914-139416414 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:139416415-139416915 Neighboring gene Sharpr-MPRA regulatory region 6205 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26769 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18699 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18700 Neighboring gene Sharpr-MPRA regulatory region 3006 Neighboring gene MPRA-validated peak6784 silencer Neighboring gene thromboxane A synthase 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:139528736-139529935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26770 Neighboring gene uncharacterized LOC107986853

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The sequence of the human genome. Venter JC, et al. Science, 2001 Feb 16. PMID 11181995
    2. Large-scale mapping of human protein-protein interactions by mass spectrometry. Ewing RM, et al. Mol Syst Biol, 2007. PMID 17353931, Free PMC Article
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ32986

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    C-type lectin domain family 2 member L

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080511.4 → NP_001073980.2  C-type lectin domain family 2 member L isoform 1

      See identical proteins and their annotated locations for NP_001073980.2

      Status: VALIDATED

      Source sequence(s)
      AC005531, HY072821
      Consensus CDS
      CCDS47724.1
      UniProtKB/Swiss-Prot
      P0C7M8
      Related
      ENSP00000390661.2, ENST00000422142.7
      Conserved Domains (1) summary
      cd03593
      Location:100 → 210
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    2. NM_001353368.2 → NP_001340297.1  C-type lectin domain family 2 member L isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC005531
      Conserved Domains (1) summary
      cd03593
      Location:75 → 185
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      139523685..139544985
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017011770.3 → XP_016867259.1  C-type lectin domain family 2 member L isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      140836984..140858283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357343.1 → XP_054213318.1  C-type lectin domain family 2 member L isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C7M8.1 GenPept UniProtKB/Swiss-Prot:P0C7M8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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