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    DNAJC18 DnaJ heat shock protein family (Hsp40) member C18 [ Homo sapiens (human) ]

    Gene ID: 202052, updated on 10-Dec-2024

    Summary

    Official Symbol
    DNAJC18provided by HGNC
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member C18provided by HGNC
    Primary source
    HGNC:HGNC:28429
    See related
    Ensembl:ENSG00000170464 AllianceGenome:HGNC:28429
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable Hsp70 protein binding activity. Predicted to be involved in cellular response to misfolded protein and chaperone cofactor-dependent protein refolding. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in brain (RPKM 11.6), testis (RPKM 9.5) and 21 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See DNAJC18 in Genome Data Viewer
    Location:
    5q31.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (139410203..139439525, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (139936006..139965339, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (138745892..138775214, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23224 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:138723739-138724286 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:138724287-138724834 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:138724835-138725382 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23225 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16409 Neighboring gene Sharpr-MPRA regulatory region 996 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16410 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23227 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23228 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16411 Neighboring gene marginal zone B and B1 cell specific protein Neighboring gene spermatogenesis associated 24 Neighboring gene proline rich basic protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23229 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23230 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:138739142-138739715 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:138739716-138740288 Neighboring gene uncharacterized LOC124901082 Neighboring gene NANOG hESC enhancer GRCh37_chr5:138755520-138756025 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16412 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:138773284-138773784 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16413 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:138775085-138775584 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23232 Neighboring gene RNA, U5B small nuclear 4, pseudogene Neighboring gene endothelial cell surface expressed chemotaxis and apoptosis regulator Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23233 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:138840510-138841099 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:138841100-138841688 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:138842278-138842865

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Interactions

    General gene information

    Potential readthrough

    Included gene: ECSCR

    Clone Names

    • FLJ56777, MGC29463

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables Hsp70 protein binding  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane  
    located_in endoplasmic reticulum membrane PubMed 

    General protein information

    Preferred Names
    dnaJ homolog subfamily C member 18
    Names
    DnaJ (Hsp40) homolog, subfamily C, member 18

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152686.4 → NP_689899.1  dnaJ homolog subfamily C member 18

      See identical proteins and their annotated locations for NP_689899.1

      Status: VALIDATED

      Source sequence(s)
      AC142391, BC030162, BU735127, DA497858
      Consensus CDS
      CCDS4214.1
      UniProtKB/Swiss-Prot
      Q9H819
      Related
      ENSP00000302843.5, ENST00000302060.10
      Conserved Domains (2) summary
      pfam00226
      Location:82 → 143
      DnaJ; DnaJ domain
      pfam09320
      Location:250 → 350
      DUF1977; Domain of unknown function (DUF1977)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      139410203..139439525 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_021159996.1 Reference GRCh38.p14 PATCHES

      Range
      732..30054 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      139936006..139965339 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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