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    AUNIP aurora kinase A and ninein interacting protein [ Homo sapiens (human) ]

    Gene ID: 79000, updated on 10-Dec-2024

    Summary

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    Official Symbol
    AUNIPprovided by HGNC
    Official Full Name
    aurora kinase A and ninein interacting proteinprovided by HGNC
    Primary source
    HGNC:HGNC:28363
    See related
    Ensembl:ENSG00000127423 MIM:620397; AllianceGenome:HGNC:28363
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AIBP; C1orf135
    Summary
    Enables damaged DNA binding activity. Involved in double-strand break repair via homologous recombination; negative regulation of double-strand break repair via nonhomologous end joining; and spindle organization. Located in centrosome; site of DNA damage; and spindle pole. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 11.8), adrenal (RPKM 7.3) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See AUNIP in Genome Data Viewer
    Location:
    1p36.11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (25831906..25859457, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (25669339..25696890, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (26158397..26185948, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene selenoprotein N Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26137118-26137992 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26144488-26144988 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 462 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 466 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 463 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 467 Neighboring gene uncharacterized LOC646471 Neighboring gene mitochondrial fission regulator 1 like Neighboring gene hESC enhancers GRCh37_chr1:26185603-26186228 and GRCh37_chr1:26186229-26186854 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26189139-26189908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26196207-26196708 Neighboring gene progestin and adipoQ receptor family member 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 469 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 470 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:26201379-26201878 Neighboring gene stathmin 1 Neighboring gene small nuclear ribonucleoprotein polypeptide F pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of AUNIP as a candidate diagnostic and prognostic biomarker for oral squamous cell carcinoma. Yang Z, et al. EBioMedicine, 2019 Sep. PMID 31409573, Free PMC Article
    2. AUNIP/C1orf135 directs DNA double-strand breaks towards the homologous recombination repair pathway. Lou J, et al. Nat Commun, 2017 Oct 17. PMID 29042561, Free PMC Article
    3. Functional characterization of AIBp, a novel Aurora-A binding protein in centrosome structure and spindle formation. Lieu AS, et al. Int J Oncol, 2010 Aug. PMID 20596670
    4. A Y2H-seq approach defines the human protein methyltransferase interactome. Weimann M, et al. Nat Methods, 2013 Apr. PMID 23455924
    5. Phospho-tyrosine dependent protein-protein interaction network. Grossmann A, et al. Mol Syst Biol, 2015 Mar 26. PMID 25814554, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC2603, FLJ14264

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables damaged DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in double-strand break repair via homologous recombination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of double-strand break repair via nonhomologous end joining IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in site of DNA damage IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aurora kinase A- and ninein-interacting protein
    Names
    aurora A-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001287490.2 → NP_001274419.1  aurora kinase A- and ninein-interacting protein isoform 1

      See identical proteins and their annotated locations for NP_001274419.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AL020996, BF987554, BJ989876, GQ844687
      Consensus CDS
      CCDS72731.1
      UniProtKB/Swiss-Prot
      Q9H7T9
      Related
      ENSP00000443647.1, ENST00000538789.5
      Conserved Domains (1) summary
      pfam15334
      Location:26 → 348
      AIB; Aurora kinase A and ninein interacting protein

    2. NM_024037.3 → NP_076942.1  aurora kinase A- and ninein-interacting protein isoform 2

      See identical proteins and their annotated locations for NP_076942.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 3' terminal exon, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AI198661, AL020996, BC000209, BJ989876
      Consensus CDS
      CCDS266.1
      UniProtKB/Swiss-Prot
      C9EI59, Q53F70, Q9H7T9
      Related
      ENSP00000363416.4, ENST00000374298.4
      Conserved Domains (1) summary
      pfam15334
      Location:26 → 350
      AIB; Aurora kinase A and ninein interacting protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      25831906..25859457 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047430116.1 → XP_047286072.1  aurora kinase A- and ninein-interacting protein isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      25669339..25696890 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338672.1 → XP_054194647.1  aurora kinase A- and ninein-interacting protein isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H7T9.1 GenPept UniProtKB/Swiss-Prot:Q9H7T9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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