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    CENPB centromere protein B [ Homo sapiens (human) ]

    Gene ID: 1059, updated on 27-Nov-2024

    Summary

    Official Symbol
    CENPBprovided by HGNC
    Official Full Name
    centromere protein Bprovided by HGNC
    Primary source
    HGNC:HGNC:1852
    See related
    Ensembl:ENSG00000125817 MIM:117140; AllianceGenome:HGNC:1852
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies. [provided by RefSeq, Jul 2008]
    Orthologs
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    Genomic context

    See CENPB in Genome Data Viewer
    Location:
    20p13
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (3783851..3786740, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (3814791..3817680, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (3764498..3767387, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene adipose secreted signaling protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:3747545-3748309 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:3748437-3749023 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17482 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12627 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:3759113-3759730 Neighboring gene Sharpr-MPRA regulatory region 2213 Neighboring gene sperm flagellar 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:3766083-3766793 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:3766794-3767503 Neighboring gene cell division cycle 25B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:3775953-3776684 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12629 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12630 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:3777341-3777548 Neighboring gene Sharpr-MPRA regulatory region 3723 Neighboring gene Sharpr-MPRA regulatory region 8683 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:3782484-3783683 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:3787799-3788390 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:3788391-3788981 Neighboring gene long intergenic non-protein coding RNA 1730 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:3791796-3792995

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables centromeric DNA binding IC
    Inferred by Curator
    more info
    PubMed 
    enables chromatin binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables satellite DNA binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables sequence-specific DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in condensed chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in pericentric heterochromatin IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    major centromere autoantigen B
    Names
    CENP-B
    centromere autoantigen B
    centromere protein B, 80kDa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001810.6NP_001801.1  major centromere autoantigen B

      See identical proteins and their annotated locations for NP_001801.1

      Status: REVIEWED

      Source sequence(s)
      AL109804, BC003649, BC053847
      Consensus CDS
      CCDS13064.1
      UniProtKB/Swiss-Prot
      P07199, Q96EI4
      Related
      ENSP00000369075.4, ENST00000379751.5
      Conserved Domains (4) summary
      smart00674
      Location:74135
      CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
      pfam03184
      Location:222384
      DDE_1; DDE superfamily endonuclease
      pfam04218
      Location:256
      CENP-B_N; CENP-B N-terminal DNA-binding domain
      pfam09026
      Location:539598
      CENP-B_dimeris; Centromere protein B dimerization domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      3783851..3786740 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      3814791..3817680 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)