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    CDK5R1 cyclin dependent kinase 5 regulatory subunit 1 [ Homo sapiens (human) ]

    Gene ID: 8851, updated on 9-Dec-2024

    Summary

    Official Symbol
    CDK5R1provided by HGNC
    Official Full Name
    cyclin dependent kinase 5 regulatory subunit 1provided by HGNC
    Primary source
    HGNC:HGNC:1775
    See related
    Ensembl:ENSG00000176749 MIM:603460; AllianceGenome:HGNC:1775
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p23; p25; p35; CDK5R; NCK5A; CDK5P35; p35nck5a
    Summary
    The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 36.6), lymph node (RPKM 6.6) and 5 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CDK5R1 in Genome Data Viewer
    Location:
    17q11.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (32486993..32491253)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (33432760..33437020)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (30814011..30818271)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:30771309-30771924 Neighboring gene nudix hydrolase 15 pseudogene 2 Neighboring gene proteasome 26S subunit, non-ATPase 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:30812797-30813298 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8422 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8423 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:30814538-30815097 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:30817300-30817421 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12031 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8425 Neighboring gene uncharacterized LOC124903982 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:30824438-30824945 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:30830591-30831361 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:30832133-30832903 Neighboring gene uncharacterized LOC105371734 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12032 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12033 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12034 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8426 Neighboring gene uncharacterized LOC107985012 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8427 Neighboring gene myosin ID

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat decreases the levels of Egr-1 and p35 expression in nerve growth factor (NGF)-treated neural cells PubMed
    tat Neural cells expressing Tat reduces the phosphorylation level of neurofilaments by p35/Cdk5 PubMed
    tat HIV-1 Tat downregulates the expression of p35, a neuron-specific activator of cdk5, and also binds to Puralpha, which associates with cdk5, leading to deregulation of neuronal differentiation and survival PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC33831

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
     
    NOT enables alpha-tubulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables alpha-tubulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT enables beta-tubulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables beta-tubulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables cadherin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables cyclin-dependent protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cyclin-dependent protein serine/threonine kinase activator activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables cyclin-dependent protein serine/threonine kinase activator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables ephrin receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ionotropic glutamate receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protease binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine/threonine kinase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled acetylcholine receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in G1 to G0 transition involved in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in axon guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in axonal fasciculation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in brain development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in brain development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cerebellum development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryo development ending in birth or egg hatching IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ephrin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in hippocampus development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ionotropic glutamate receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in layer formation in cerebral cortex IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in microtubule cytoskeleton organization TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron cell-cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuron differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuron migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuron projection development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-threonine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of MHC class II biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of microtubule polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of neuron apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein targeting to membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cyclin-dependent protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of dendritic spine morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of macroautophagy NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of neuron differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of synaptic vesicle cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in superior olivary nucleus maturation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in contractile muscle fiber ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of cyclin-dependent protein kinase holoenzyme complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in dendritic spine ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in growth cone IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in growth cone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in neuromuscular junction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in neuron projection ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in neuronal cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in postsynaptic density ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein kinase 5 complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    cyclin-dependent kinase 5 activator 1
    Names
    CDK5 activator 1
    TPKII regulatory subunit
    neuronal CDK5 activator
    regulatory partner for CDK5 kinase
    tau protein kinase II 23kDa subunit

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003885.3NP_003876.1  cyclin-dependent kinase 5 activator 1

      See identical proteins and their annotated locations for NP_003876.1

      Status: REVIEWED

      Source sequence(s)
      AC079336
      Consensus CDS
      CCDS11273.1
      UniProtKB/Swiss-Prot
      E1P664, Q15078, Q5U0G3
      UniProtKB/TrEMBL
      Q8N619, Q8TAM4
      Related
      ENSP00000318486.3, ENST00000313401.4
      Conserved Domains (1) summary
      pfam03261
      Location:20293
      CDK5_activator; Cyclin-dependent kinase 5 activator protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      32486993..32491253
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      33432760..33437020
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)