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    KIF1A kinesin family member 1A [ Homo sapiens (human) ]

    Gene ID: 547, updated on 10-Dec-2024

    Summary

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    Official Symbol
    KIF1Aprovided by HGNC
    Official Full Name
    kinesin family member 1Aprovided by HGNC
    Primary source
    HGNC:HGNC:888
    See related
    Ensembl:ENSG00000130294 MIM:601255; AllianceGenome:HGNC:888
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ATSV; MRD9; HSN2C; SPG30; SPG30A; SPG30B; UNC104; C2orf20; NESCAVS
    Summary
    The protein encoded by this gene is a member of the kinesin family and functions as an anterograde motor protein that transports membranous organelles along axonal microtubules. Mutations at this locus have been associated with spastic paraplegia-30 and hereditary sensory neuropathy IIC. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Apr 2012]
    Expression
    Biased expression in brain (RPKM 88.6), adrenal (RPKM 8.2) and 1 other tissue See more
    Orthologs
    mouse all
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    Genomic context

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    See KIF1A in Genome Data Viewer
    Location:
    2q37.3
    Exon count:
    55
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (240713767..240821403, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (241210501..241320366, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (241653184..241760820, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC285191 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241637868-241638651 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:241646918-241647077 Neighboring gene aquaporin 12A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241651331-241652138 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241673162-241673662 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:241678910-241680109 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241736458-241736958 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241736959-241737459 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241737588-241738429 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241751150-241751760 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241756052-241756691 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241760048-241760622 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:241771685-241772681 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241778610-241779110 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241807760-241808260 Neighboring gene alanine--glyoxylate aminotransferase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241834201-241834836 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:241836109-241836744 Neighboring gene mab-21 like 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Polyglutamylation of tubulin's C-terminal tail controls pausing and motility of kinesin-3 family member KIF1A. Lessard DV, et al. J Biol Chem, 2019 Apr 19. PMID 30770469, Free PMC Article
    2. Phenotypic expansion in KIF1A-related dominant disorders: A description of novel variants and review of published cases. Montenegro-Garreaud X, et al. Hum Mutat, 2020 Dec. PMID 32935419, Free PMC Article
    3. Autosomal recessive spastic paraplegia (SPG30) with mild ataxia and sensory neuropathy maps to chromosome 2q37.3. Klebe S, et al. Brain, 2006 Jun. PMID 16434418
    4. Heterozygous KIF1A variants underlie a wide spectrum of neurodevelopmental and neurodegenerative disorders. Nicita F, et al. J Med Genet, 2021 Jul. PMID 32737135
    5. High-resolution cryo-EM maps show the nucleotide binding pocket of KIF1A in open and closed conformations. Kikkawa M, et al. EMBO J, 2006 Sep 20. PMID 16946706, Free PMC Article

    See all (113) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KIF1A promotes neuroendocrine differentiation in prostate cancer by regulating the OGT-mediated O-GlcNAcylation.
      Title: KIF1A promotes neuroendocrine differentiation in prostate cancer by regulating the OGT-mediated O-GlcNAcylation.
    2. Heterogeneity of comprehensive clinical phenotype and longitudinal adaptive function and correlation with computational predictions of severity of missense genotypes in KIF1A-associated neurological disorder.
      Title: Heterogeneity of comprehensive clinical phenotype and longitudinal adaptive function and correlation with computational predictions of severity of missense genotypes in KIF1A-associated neurological disorder.
    3. KIF1A novel frameshift variant p.(Ser887Profs*64) exhibits clinical heterogeneity in a Pakistani family with hereditary sensory and autonomic neuropathy type IIC.
      Title: KIF1A novel frameshift variant p.(Ser887Profs*64) exhibits clinical heterogeneity in a Pakistani family with hereditary sensory and autonomic neuropathy type IIC.
    4. Autosomal dominant neurodevelopmental disorders associated with KIF1A gene variants in 6 pediatric patients.
      Title: Autosomal dominant neurodevelopmental disorders associated with KIF1A gene variants in 6 pediatric patients.
    5. [KIF1A gene-associated neurological disease: the correlation between genotype and phenotype].
      Title: [KIF1A gene-associated neurological disease: the correlation between genotype and phenotype].
    6. Identification of an in-frame homozygous KIF1A variant causing a mild SPG30 phenotype in a Korean family.
      Title: Identification of an in-frame homozygous KIF1A variant causing a mild SPG30 phenotype in a Korean family.
    7. [Analysis of KIF1A gene variant in a Chinese pedigree affected with Spastic paraplegia type 30].
      Title: [Analysis of KIF1A gene variant in a Chinese pedigree affected with Spastic paraplegia type 30].
    8. Insight into the regulation of axonal transport from the study of KIF1A-associated neurological disorder.
      Title: Insight into the regulation of axonal transport from the study of KIF1A-associated neurological disorder.
    9. Investigating KIF1A mutations in a Taiwanese cohort with hereditary spastic paraplegia.
      Title: Investigating KIF1A mutations in a Taiwanese cohort with hereditary spastic paraplegia.
    10. De novo mutations in KIF1A-associated neuronal disorder (KAND) dominant-negatively inhibit motor activity and axonal transport of synaptic vesicle precursors.
      Title: De novo mutations in KIF1A-associated neuronal disorder (KAND) dominant-negatively inhibit motor activity and axonal transport of synaptic vesicle precursors.
    Submit: New GeneRIF Correction See all GeneRIFs (50)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated 2013-08-08)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated 2013-08-08)

    ClinGen Genome Curation Page

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    capsid gag The ability of exogenously expressed FEZ1 binding to kinesin-1 to promote early HIV-1 infection, leading to the movement of HIV-1 CA core to the nucleus PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ30229, MGC133285, MGC133286, DKFZp686I2094

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytoskeletal motor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables plus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anterograde axonal transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in anterograde neuronal dense core vesicle transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in dense core granule cytoskeletal transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of dendritic spine development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of dendritic spine morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in retrograde neuronal dense core vesicle transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde neuronal dense core vesicle transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal dense core vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in neuronal dense core vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    kinesin-like protein KIF1A
    Names
    axonal transporter of synaptic vesicles
    kinesin, heavy chain, member 1A, homolog of mouse
    microtubule-based motor KIF1A
    unc-104- and KIF1A-related protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029724.1 RefSeqGene

      Range
      4900..111444
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_367

    mRNA and Protein(s)

    1. NM_001244008.2 → NP_001230937.1  kinesin-like protein KIF1A isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784
      Consensus CDS
      CCDS58757.1
      UniProtKB/TrEMBL
      A0A6Q8PFR5
      Related
      ENSP00000438388.1, ENST00000498729.9
      Conserved Domains (8) summary
      smart00129
      Location:5 → 361
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:501 → 605
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:1672 → 1774
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4 → 361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam00169
      Location:1677 → 1770
      PH; PH domain
      pfam12423
      Location:814 → 861
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:1297 → 1397
      DUF3694; Kinesin protein
      pfam16183
      Location:358 → 524
      Kinesin_assoc; Kinesin-associated

    2. NM_001320705.2 → NP_001307634.1  kinesin-like protein KIF1A isoform 3

      Status: REVIEWED

      Source sequence(s)
      AB210029, AB290172, AC011298, AW246876, BC111780
      Consensus CDS
      CCDS92991.1
      UniProtKB/TrEMBL
      A0A3B3IU40, X5D7J0
      Related
      ENSP00000498196.1, ENST00000648364.1
      Conserved Domains (8) summary
      smart00129
      Location:5 → 361
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:501 → 605
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:1580 → 1682
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4 → 361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam00169
      Location:1585 → 1678
      PH; PH domain
      pfam12423
      Location:814 → 860
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:1205 → 1305
      DUF3694; Kinesin protein
      pfam16183
      Location:358 → 524
      Kinesin_assoc; Kinesin-associated

    3. NM_001330289.2 → NP_001317218.1  kinesin-like protein KIF1A isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784, AK054791, AW246876
      Consensus CDS
      CCDS92992.1
      UniProtKB/TrEMBL
      A0A3B3IT28, H7C3Y8
      Related
      ENSP00000497586.1, ENST00000648680.1
      Conserved Domains (8) summary
      smart00129
      Location:5 → 361
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:501 → 605
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:1589 → 1691
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4 → 361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam00169
      Location:1594 → 1687
      PH; PH domain
      pfam12423
      Location:814 → 860
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:1205 → 1314
      DUF3694; Kinesin protein
      pfam16183
      Location:358 → 524
      Kinesin_assoc; Kinesin-associated

    4. NM_001330290.2 → NP_001317219.1  kinesin-like protein KIF1A isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784, AK054791, AW246876
      Consensus CDS
      CCDS92993.1
      UniProtKB/TrEMBL
      A0A3B3ITE5, X5D7J0
      Related
      ENSP00000497678.1, ENST00000649306.1

    5. NM_001379631.1 → NP_001366560.1  kinesin-like protein KIF1A isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784
      UniProtKB/TrEMBL
      A0A6Q8PFR5

    6. NM_001379632.1 → NP_001366561.1  kinesin-like protein KIF1A isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784
      UniProtKB/TrEMBL
      A0AAQ5BID6
      Conserved Domains (6) summary
      cd00060
      Location:492 → 596
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:1664 → 1766
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4 → 361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam12423
      Location:805 → 852
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:1233 → 1389
      DUF3694; Kinesin protein
      pfam16183
      Location:358 → 515
      Kinesin_assoc; Kinesin-associated

    7. NM_001379633.1 → NP_001366562.1  kinesin-like protein KIF1A isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784
      Consensus CDS
      CCDS92990.1
      UniProtKB/TrEMBL
      A0A3B3ITW6, A0AAQ5BID6
      Related
      ENSP00000497293.1, ENST00000648129.1

    8. NM_001379634.1 → NP_001366563.1  kinesin-like protein KIF1A isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784
      UniProtKB/TrEMBL
      H7C3Y8

    9. NM_001379635.1 → NP_001366564.1  kinesin-like protein KIF1A isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784
      UniProtKB/TrEMBL
      A0A3B3ITK3, H7C3Y8
      Conserved Domains (6) summary
      cd00060
      Location:526 → 630
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:1613 → 1715
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4 → 361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam12423
      Location:839 → 885
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:1183 → 1338
      DUF3694; Kinesin protein
      pfam16183
      Location:358 → 549
      Kinesin_assoc; Kinesin-associated

    10. NM_001379636.1 → NP_001366565.1  kinesin-like protein KIF1A isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784
      Consensus CDS
      CCDS92989.1
      UniProtKB/TrEMBL
      A0A3B3ITF7, X5D7J0
      Related
      ENSP00000497739.1, ENST00000647885.1
      Conserved Domains (7) summary
      cd01233
      Location:1609 → 1711
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4 → 361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam00769
      Location:624 → 678
      ERM; Ezrin/radixin/moesin family
      pfam12423
      Location:805 → 852
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:1149 → 1331
      DUF3694; Kinesin protein
      pfam16183
      Location:358 → 515
      Kinesin_assoc; Kinesin-associated
      cd22726
      Location:491 → 605
      FHA_KIF1A; forkhead associated (FHA) domain found in kinesin-like protein KIF1A

    11. NM_001379637.1 → NP_001366566.1  kinesin-like protein KIF1A isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784
      UniProtKB/TrEMBL
      X5D7J0
      Conserved Domains (7) summary
      cd01233
      Location:1596 → 1698
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4 → 361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam00769
      Location:649 → 703
      ERM; Ezrin/radixin/moesin family
      pfam12423
      Location:830 → 877
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:1174 → 1318
      DUF3694; Kinesin protein
      pfam16183
      Location:358 → 540
      Kinesin_assoc; Kinesin-associated
      cd22726
      Location:516 → 630
      FHA_KIF1A; forkhead associated (FHA) domain found in kinesin-like protein KIF1A

    12. NM_001379638.1 → NP_001366567.1  kinesin-like protein KIF1A isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784
      UniProtKB/TrEMBL
      H7C3Y8
      Conserved Domains (6) summary
      cd00060
      Location:501 → 605
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:1588 → 1690
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4 → 361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam12423
      Location:814 → 860
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:1158 → 1313
      DUF3694; Kinesin protein
      pfam16183
      Location:358 → 524
      Kinesin_assoc; Kinesin-associated

    13. NM_001379639.1 → NP_001366568.1  kinesin-like protein KIF1A isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784
      Consensus CDS
      CCDS92987.1
      UniProtKB/TrEMBL
      A0A3F2YNW9, X5D7J0
      Related
      ENSP00000322791.8, ENST00000320389.12
      Conserved Domains (6) summary
      cd00060
      Location:492 → 596
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:1579 → 1681
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4 → 361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam12423
      Location:805 → 851
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:1149 → 1304
      DUF3694; Kinesin protein
      pfam16183
      Location:358 → 515
      Kinesin_assoc; Kinesin-associated

    14. NM_001379640.1 → NP_001366569.1  kinesin-like protein KIF1A isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784
      UniProtKB/TrEMBL
      X5D7J0
      Conserved Domains (6) summary
      cd00060
      Location:492 → 596
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:1570 → 1672
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4 → 361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam12423
      Location:805 → 851
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:1148 → 1295
      DUF3694; Kinesin protein
      pfam16183
      Location:358 → 515
      Kinesin_assoc; Kinesin-associated

    15. NM_001379641.1 → NP_001366570.1  kinesin-like protein KIF1A isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784
      UniProtKB/TrEMBL
      X5D7J0
      Conserved Domains (6) summary
      cd00060
      Location:492 → 596
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:1571 → 1661
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4 → 361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam12423
      Location:805 → 851
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:1149 → 1296
      DUF3694; Kinesin protein
      pfam16183
      Location:358 → 515
      Kinesin_assoc; Kinesin-associated

    16. NM_001379642.1 → NP_001366571.1  kinesin-like protein KIF1A isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784
      UniProtKB/TrEMBL
      A0AAQ5BID6
      Conserved Domains (6) summary
      cd00060
      Location:492 → 596
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:1672 → 1774
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4 → 361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam12423
      Location:805 → 852
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:1241 → 1397
      DUF3694; Kinesin protein
      pfam16183
      Location:358 → 515
      Kinesin_assoc; Kinesin-associated

    17. NM_001379645.1 → NP_001366574.1  kinesin-like protein KIF1A isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784
      Consensus CDS
      CCDS92990.1
      UniProtKB/TrEMBL
      A0A3B3ITW6, A0AAQ5BID6
      Related
      ENSP00000498082.1, ENST00000650130.1

    18. NM_001379646.1 → NP_001366575.1  kinesin-like protein KIF1A isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784
      UniProtKB/TrEMBL
      A0A3B3ITK3, H7C3Y8
      Related
      ENSP00000497935.2, ENST00000648047.2
      Conserved Domains (6) summary
      cd00060
      Location:526 → 630
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:1613 → 1715
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4 → 361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam12423
      Location:839 → 885
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:1183 → 1338
      DUF3694; Kinesin protein
      pfam16183
      Location:358 → 549
      Kinesin_assoc; Kinesin-associated

    19. NM_001379648.1 → NP_001366577.1  kinesin-like protein KIF1A isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784
      UniProtKB/TrEMBL
      H7C3Y8
      Conserved Domains (3) summary
      cd00060
      Location:517 → 621
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:1605 → 1707
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4 → 361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

    20. NM_001379649.1 → NP_001366578.1  kinesin-like protein KIF1A isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784
      Consensus CDS
      CCDS92988.1
      UniProtKB/TrEMBL
      A0A3B3IUA1, X5D7J0
      Related
      ENSP00000498099.1, ENST00000647731.1
      Conserved Domains (6) summary
      cd00060
      Location:492 → 596
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:1580 → 1682
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4 → 361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam12423
      Location:805 → 851
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:1149 → 1305
      DUF3694; Kinesin protein
      pfam16183
      Location:358 → 515
      Kinesin_assoc; Kinesin-associated

    21. NM_001379650.1 → NP_001366579.1  kinesin-like protein KIF1A isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784
      Consensus CDS
      CCDS46561.1
      UniProtKB/Swiss-Prot
      B0I1S5, F5H045, O95068, Q12756, Q13355, Q14752, Q2NKJ6, Q4LE42, Q53T78, Q59GH1, Q63Z40, Q6P1R9, Q7KZ57
      UniProtKB/TrEMBL
      X5D7J0
      Related
      ENSP00000497824.1, ENST00000650053.1
      Conserved Domains (6) summary
      cd00060
      Location:492 → 596
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:1571 → 1673
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4 → 361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam12423
      Location:805 → 851
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:1149 → 1296
      DUF3694; Kinesin protein
      pfam16183
      Location:358 → 515
      Kinesin_assoc; Kinesin-associated

    22. NM_001379651.1 → NP_001366580.1  kinesin-like protein KIF1A isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784
      Consensus CDS
      CCDS46561.1
      UniProtKB/Swiss-Prot
      B0I1S5, F5H045, O95068, Q12756, Q13355, Q14752, Q2NKJ6, Q4LE42, Q53T78, Q59GH1, Q63Z40, Q6P1R9, Q7KZ57
      UniProtKB/TrEMBL
      X5D7J0
      Conserved Domains (6) summary
      cd00060
      Location:492 → 596
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:1571 → 1673
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4 → 361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam12423
      Location:805 → 851
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:1149 → 1296
      DUF3694; Kinesin protein
      pfam16183
      Location:358 → 515
      Kinesin_assoc; Kinesin-associated

    23. NM_001379653.1 → NP_001366582.1  kinesin-like protein KIF1A isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784
      Consensus CDS
      CCDS46561.1
      UniProtKB/Swiss-Prot
      B0I1S5, F5H045, O95068, Q12756, Q13355, Q14752, Q2NKJ6, Q4LE42, Q53T78, Q59GH1, Q63Z40, Q6P1R9, Q7KZ57
      UniProtKB/TrEMBL
      X5D7J0
      Conserved Domains (6) summary
      cd00060
      Location:492 → 596
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:1571 → 1673
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4 → 361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam12423
      Location:805 → 851
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:1149 → 1296
      DUF3694; Kinesin protein
      pfam16183
      Location:358 → 515
      Kinesin_assoc; Kinesin-associated

    24. NM_004321.8 → NP_004312.2  kinesin-like protein KIF1A isoform 2

      See identical proteins and their annotated locations for NP_004312.2

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784
      Consensus CDS
      CCDS46561.1
      UniProtKB/Swiss-Prot
      B0I1S5, F5H045, O95068, Q12756, Q13355, Q14752, Q2NKJ6, Q4LE42, Q53T78, Q59GH1, Q63Z40, Q6P1R9, Q7KZ57
      UniProtKB/TrEMBL
      X5D7J0
      Related
      ENSP00000497030.1, ENST00000649096.1
      Conserved Domains (6) summary
      cd00060
      Location:492 → 596
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:1571 → 1673
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4 → 361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam12423
      Location:805 → 851
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:1149 → 1296
      DUF3694; Kinesin protein
      pfam16183
      Location:358 → 515
      Kinesin_assoc; Kinesin-associated

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      240713767..240821403 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047444819.1 → XP_047300775.1  kinesin-like protein KIF1A isoform X1

      UniProtKB/TrEMBL
      A0A6Q8PFR5, C9JBH1

    2. XM_047444821.1 → XP_047300777.1  kinesin-like protein KIF1A isoform X3

      UniProtKB/TrEMBL
      A0A6Q8PFR5

    3. XM_047444820.1 → XP_047300776.1  kinesin-like protein KIF1A isoform X2

      UniProtKB/TrEMBL
      A0A6Q8PFR5
      Related
      ENSP00000384231.5, ENST00000404283.9

    4. XM_047444818.1 → XP_047300774.1  kinesin-like protein KIF1A isoform X1

      UniProtKB/TrEMBL
      A0A6Q8PFR5, C9JBH1
      Related
      ENSP00000398686.2, ENST00000448728.2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      241210501..241320366 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054342651.1 → XP_054198626.1  kinesin-like protein KIF1A isoform X1

      UniProtKB/TrEMBL
      A0A6Q8PFR5

    2. XM_054342653.1 → XP_054198628.1  kinesin-like protein KIF1A isoform X3

      UniProtKB/TrEMBL
      A0A6Q8PFR5

    3. XM_054342652.1 → XP_054198627.1  kinesin-like protein KIF1A isoform X2

      UniProtKB/TrEMBL
      A0A6Q8PFR5

    4. XM_054342650.1 → XP_054198625.1  kinesin-like protein KIF1A isoform X1

      UniProtKB/TrEMBL
      A0A6Q8PFR5

    5. XM_054342654.1 → XP_054198629.1  kinesin-like protein KIF1A isoform X4

      UniProtKB/TrEMBL
      A0AAQ5BID6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12756.2 GenPept UniProtKB/Swiss-Prot:Q12756

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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