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    ZMYM4 zinc finger MYM-type containing 4 [ Homo sapiens (human) ]

    Gene ID: 9202, updated on 10-Dec-2024

    Summary

    Official Symbol
    ZMYM4provided by HGNC
    Official Full Name
    zinc finger MYM-type containing 4provided by HGNC
    Primary source
    HGNC:HGNC:13055
    See related
    Ensembl:ENSG00000146463 MIM:613568; AllianceGenome:HGNC:13055
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MYM; CDIR; ZNF262; ZNF198L3
    Summary
    Predicted to enable DNA binding activity. Involved in cytoskeleton organization and regulation of cell morphogenesis. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis (RPKM 15.0), ovary (RPKM 10.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZMYM4 in Genome Data Viewer
    Location:
    1p34.3
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (35268709..35422058)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (35131764..35285115)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (35734310..35887659)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378644 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 636 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 637 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:35658451-35659243 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 725 Neighboring gene Sharpr-MPRA regulatory region 666 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:35676251-35676918 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:35681555-35682151 Neighboring gene splicing factor proline and glutamine rich Neighboring gene ATAC-STARR-seq lymphoblastoid active region 726 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 727 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 638 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 639 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:35738409-35738909 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:35766904-35767102 Neighboring gene RNA, 7SL, cytoplasmic 503, pseudogene Neighboring gene small nucleolar RNA SNORA62/SNORA6 family Neighboring gene NANOG hESC enhancer GRCh37_chr1:35827234-35827735 Neighboring gene ZMYM4 antisense RNA 1 Neighboring gene ribosomal protein L5 pseudogene 4 Neighboring gene MPRA-validated peak172 silencer Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:35855531-35856150 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:35856151-35856768 Neighboring gene KIAA0319 like Neighboring gene ReSE screen-validated silencer GRCh37_chr1:35916701-35916880 Neighboring gene RNY5 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 728 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:35931229-35931375 Neighboring gene Sharpr-MPRA regulatory region 12145 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 729 Neighboring gene zinc finger protein 485 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Clone Names

    • KIAA0425, DKFZp686L0547, DKFZp686B09210

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding PubMed 
    enables protein binding PubMed 
    enables zinc ion binding  

    General protein information

    Preferred Names
    zinc finger MYM-type protein 4
    Names
    cell death inhibiting RNA
    zinc finger protein 262
    zinc finger, MYM-type 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001350138.2 → NP_001337067.1  zinc finger MYM-type protein 4 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 5' region, resulting in the use of a downstream start codon, compared the variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AB007885, AL356362, AL590434, BC012093, BC127113, BG499626, BU683493
      Conserved Domains (3) summary
      smart00746
      Location:357 → 397
      TRASH; metallochaperone-like domain
      pfam06467
      Location:449 → 489
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
      pfam12012
      Location:1324 → 1493
      DUF3504; Domain of unknown function (DUF3504)
    2. NM_001350139.2 → NP_001337068.1  zinc finger MYM-type protein 4 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon, resulting in the use of a downstream start codon, compared the variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1. Variants 3 and 4 encode the same protein (isoform 3).
      Source sequence(s)
      AB007885, AL356362, AL590434, BC012093, BG499626, BU683493, CD653525
      UniProtKB/TrEMBL
      H7C1I7
      Conserved Domains (3) summary
      smart00746
      Location:65 → 105
      TRASH; metallochaperone-like domain
      pfam06467
      Location:157 → 197
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
      pfam12012
      Location:1032 → 1201
      DUF3504; Domain of unknown function (DUF3504)
    3. NM_001350140.2 → NP_001337069.1  zinc finger MYM-type protein 4 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate exon in the 5' region, and lacks three consecutive exons, resulting in the use of a downstream start codon, compared the variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1. Variants 3 and 4 encode the same protein (isoform 3).
      Source sequence(s)
      AB007885, AL356362, AL590434, BC127113, BG499626, BU683493
      UniProtKB/TrEMBL
      H7C1I7
      Conserved Domains (3) summary
      smart00746
      Location:65 → 105
      TRASH; metallochaperone-like domain
      pfam06467
      Location:157 → 197
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
      pfam12012
      Location:1032 → 1201
      DUF3504; Domain of unknown function (DUF3504)
    4. NM_001375653.1 → NP_001362582.1  zinc finger MYM-type protein 4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL160000, AL356362, AL590434
      Conserved Domains (3) summary
      smart00746
      Location:392 → 432
      TRASH; metallochaperone-like domain
      pfam06467
      Location:484 → 524
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
      pfam12012
      Location:1365 → 1529
      DUF3504; Domain of unknown function (DUF3504)
    5. NM_005095.3 → NP_005086.2  zinc finger MYM-type protein 4 isoform 1

      See identical proteins and their annotated locations for NP_005086.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AB007885, AL356362, AL590434, BC012093, BG499626, BU683493, CD653525
      Consensus CDS
      CCDS389.1
      UniProtKB/Swiss-Prot
      A0JP19, A0JP20, O43308, Q5T5E1, Q5T5E2, Q5VZL5, Q7L3Q4
      Related
      ENSP00000322915.6, ENST00000314607.11
      Conserved Domains (3) summary
      smart00746
      Location:389 → 429
      TRASH; metallochaperone-like domain
      pfam06467
      Location:478 → 521
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
      pfam12012
      Location:1356 → 1525
      DUF3504; Domain of unknown function (DUF3504)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      35268709..35422058
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017002803.2 → XP_016858292.1  zinc finger MYM-type protein 4 isoform X1

      UniProtKB/Swiss-Prot
      Q5VZL5
      Conserved Domains (3) summary
      smart00746
      Location:357 → 397
      TRASH; metallochaperone-like domain
      pfam06467
      Location:449 → 489
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
      pfam12012
      Location:1324 → 1493
      DUF3504; Domain of unknown function (DUF3504)
    2. XM_024450838.2 → XP_024306606.1  zinc finger MYM-type protein 4 isoform X4

      UniProtKB/TrEMBL
      H7C1I7
      Conserved Domains (3) summary
      smart00746
      Location:65 → 105
      TRASH; metallochaperone-like domain
      pfam06467
      Location:157 → 197
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
      pfam12012
      Location:1032 → 1201
      DUF3504; Domain of unknown function (DUF3504)
    3. XM_047434271.1 → XP_047290227.1  zinc finger MYM-type protein 4 isoform X1

    4. XM_047434278.1 → XP_047290234.1  zinc finger MYM-type protein 4 isoform X4

      UniProtKB/TrEMBL
      H7C1I7
    5. XM_047434282.1 → XP_047290238.1  zinc finger MYM-type protein 4 isoform X6

      UniProtKB/TrEMBL
      H7C1I7
    6. XM_047434270.1 → XP_047290226.1  zinc finger MYM-type protein 4 isoform X1

    7. XM_005271331.3 → XP_005271388.1  zinc finger MYM-type protein 4 isoform X4

      See identical proteins and their annotated locations for XP_005271388.1

      UniProtKB/TrEMBL
      H7C1I7
      Conserved Domains (3) summary
      smart00746
      Location:65 → 105
      TRASH; metallochaperone-like domain
      pfam06467
      Location:157 → 197
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
      pfam12012
      Location:1032 → 1201
      DUF3504; Domain of unknown function (DUF3504)
    8. XM_047434289.1 → XP_047290245.1  zinc finger MYM-type protein 4 isoform X6

      UniProtKB/TrEMBL
      H7C1I7
    9. XM_047434269.1 → XP_047290225.1  zinc finger MYM-type protein 4 isoform X1

    10. XM_047434276.1 → XP_047290232.1  zinc finger MYM-type protein 4 isoform X3

    11. XM_047434274.1 → XP_047290230.1  zinc finger MYM-type protein 4 isoform X2

      UniProtKB/TrEMBL
      H7C1I7
      Related
      ENSP00000400506.1, ENST00000457946.1
    12. XM_047434279.1 → XP_047290235.1  zinc finger MYM-type protein 4 isoform X5

      UniProtKB/TrEMBL
      H7C1I7

    RNA

    1. XR_246305.5 RNA Sequence

    2. XR_007064889.1 RNA Sequence

    3. XR_007064890.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      35131764..35285115
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339605.1 → XP_054195580.1  zinc finger MYM-type protein 4 isoform X1

    2. XM_054339610.1 → XP_054195585.1  zinc finger MYM-type protein 4 isoform X4

      UniProtKB/TrEMBL
      H7C1I7
    3. XM_054339604.1 → XP_054195579.1  zinc finger MYM-type protein 4 isoform X1

    4. XM_054339608.1 → XP_054195583.1  zinc finger MYM-type protein 4 isoform X4

      UniProtKB/TrEMBL
      H7C1I7
    5. XM_054339612.1 → XP_054195587.1  zinc finger MYM-type protein 4 isoform X6

      UniProtKB/TrEMBL
      H7C1I7
    6. XM_054339603.1 → XP_054195578.1  zinc finger MYM-type protein 4 isoform X1

    7. XM_054339609.1 → XP_054195584.1  zinc finger MYM-type protein 4 isoform X4

      UniProtKB/TrEMBL
      H7C1I7
    8. XM_054339613.1 → XP_054195588.1  zinc finger MYM-type protein 4 isoform X6

      UniProtKB/TrEMBL
      H7C1I7
    9. XM_054339602.1 → XP_054195577.1  zinc finger MYM-type protein 4 isoform X1

    10. XM_054339607.1 → XP_054195582.1  zinc finger MYM-type protein 4 isoform X3

    11. XM_054339606.1 → XP_054195581.1  zinc finger MYM-type protein 4 isoform X2

      UniProtKB/TrEMBL
      H7C1I7
    12. XM_054339611.1 → XP_054195586.1  zinc finger MYM-type protein 4 isoform X5

      UniProtKB/TrEMBL
      H7C1I7

    RNA

    1. XR_008486206.1 RNA Sequence

    2. XR_008486207.1 RNA Sequence

    3. XR_008486208.1 RNA Sequence

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