Inhca inhibitor of carbonic anhydrase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Inhcaprovided by MGI
Official Full Name: inhibitor of carbonic anhydraseprovided by MGI
Primary source: MGI:MGI:1919025
See related: Ensembl:ENSMUSG00000033688 AllianceGenome:MGI:1919025
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ica; mICA; 1300017J02Rik
Summary: This gene is a member of the transferrin gene family. Unlike many members of that gene family it does not play a significant role in iron homeostasis but rather is an inhibitor of carbonic anhydrase. This gene arose as a tandem duplicate of the adjacent transferrin gene sometime after the divergence of monotremes and therian mammals but before the diversification of placental mammals. This gene subsequently became a pseudogene in monkeys and apes. In lemurs and other strepsirrhine primates it possibly remains a protein coding gene. [provided by RefSeq, Oct 2021]
Expression: Biased expression in liver adult (RPKM 103.2), liver E18 (RPKM 82.3) and 4 other tissues See more
Orthologs: all
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Genomic context

Location:: 9 F1; 9 55.1 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (103127722..103165496, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (103250523..103288297, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Murine inhibitor of carbonic anhydrase was a glycoprotein that associated with carbonic anhydrase in a 1:1 stoichiometry.[ICA]
Title: A novel murine protein with no effect on iron homoeostasis is homologous with transferrin and is the putative inhibitor of carbonic anhydrase.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)

General gene information

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Markers

D9Mit347 (e-PCR), detects polymorphism
- UniSTS:131910

D9Mgc21 (e-PCR), detects polymorphism
- UniSTS:142761

D9Mgc23 (e-PCR), detects polymorphism
- UniSTS:142763

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables iron ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in antibacterial humoral response	IBA Inferred from Biological aspect of Ancestor more info
involved_in iron ion transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in recycling endosome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: inhibitor of carbonic anhydrase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027918.2 → NP_082194.1 inhibitor of carbonic anhydrase precursor

See identical proteins and their annotated locations for NP_082194.1

Status: PROVISIONAL

Source sequence(s)

AK005035

Consensus CDS

CCDS23452.1

UniProtKB/Swiss-Prot

Q9DBD0

UniProtKB/TrEMBL

Q8VC96

Related

ENSMUSP00000035163.4, ENSMUST00000035163.10

Conserved Domains (4) summary

smart00094
Location:355 → 685

TR_FER; Transferrin

cd13617
Location:352 → 684

PBP2_transferrin_C; The C-lobe of transferrin, a member of the type 2 periplasmic binding protein fold superfamily

cd13618
Location:24 → 346

PBP2_transferrin_N; The N-lobe of transferrin, a member of the type 2 periplasmic binding protein fold superfamily

pfam00405
Location:25 → 346

Transferrin; Transferrin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

103127722..103165496 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006511835.4 → XP_006511898.1 inhibitor of carbonic anhydrase isoform X1

Conserved Domains (2) summary

cd13617
Location:120 → 452

PBP2_transferrin_C; The C-lobe of transferrin, a member of the type 2 periplasmic binding protein fold superfamily

cl21456
Location:1 → 114

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily