Stk39 serine threonine kinase 39 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Stk39provided by RGD
Official Full Name: serine threonine kinase 39provided by RGD
Primary source: RGD:621643
See related: EnsemblRapid:ENSRNOG00000024808 AllianceGenome:RGD:621643
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Spak
Summary: Enables protein kinase binding activity and protein serine/threonine kinase activity. Involved in positive regulation of monoatomic ion transport; positive regulation of p38MAPK cascade; and protein autophosphorylation. Located in cell cortex and cytosol. Orthologous to human STK39 (serine/threonine kinase 39). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 203.1), Brain (RPKM 154.4) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q21

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (73321522..73588397, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (52913583..53179060, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (54359449..54625702, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kidney Injury Causes Accumulation of Renal Sodium That Modulates Renal Lymphatic Dynamics.
Title: Kidney Injury Causes Accumulation of Renal Sodium That Modulates Renal Lymphatic Dynamics.
Inhibition of the pSPAK/pNKCC1 signaling pathway protects the bloodbrain barrier and reduces neuronal apoptosis in a rat model of surgical brain injury.
Title: Inhibition of the p‑SPAK/p‑NKCC1 signaling pathway protects the blood‑brain barrier and reduces neuronal apoptosis in a rat model of surgical brain injury.
in addition to SPAK and OSR1, WNK4 is able to anchor itself to the N-terminal domain of NKCC1 and to promote cotransporter activation.
Title: A novel Ste20-related proline/alanine-rich kinase (SPAK)-independent pathway involving calcium-binding protein 39 (Cab39) and serine threonine kinase with no lysine member 4 (WNK4) in the activation of Na-K-Cl cotransporters.
SPAK and oxidative stress response kinase (OSR1) may be critical factors in the regulation of depolarizing GABA-mediated processes in the developing brain.
Title: Kinases SPAK and OSR1 are upregulated by estradiol and activate NKCC1 in the developing hypothalamus.
Two Ste20-like kinases that bind and phosphorylate NKCC1: Ste20-related proline-alanine-rich kinase (SPAK) and oxidative-stress response 1 (OSR1), were identified.
Title: The Ste20 kinases Ste20-related proline-alanine-rich kinase and oxidative-stress response 1 regulate NKCC1 function in sensory neurons.
roles in phosphorylation and activation of the Na-K-Cl cotransporter (NKCC1)
Title: PASK (proline-alanine-rich STE20-related kinase), a regulatory kinase of the Na-K-Cl cotransporter (NKCC1).
WNK1 and WNK4 both interacted with SPAK as well as a closely related kinase, termed oxidative stress response kinase-1 (OSR1).
Title: The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE107798 (e-PCR)
- UniSTS:247058

RH130764 (e-PCR)
- UniSTS:214048

AI577947 (e-PCR)
- UniSTS:248771

AW227544 (e-PCR)
- UniSTS:178632

RH138572 (e-PCR)
- UniSTS:220659

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables kinase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell volume homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cellular hyperosmotic response	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular hyperosmotic response	ISO Inferred from Sequence Orthology more info
involved_in cellular hypotonic response	ISO Inferred from Sequence Orthology more info
involved_in cellular response to chemokine	ISO Inferred from Sequence Orthology more info
involved_in cellular response to potassium ion	ISO Inferred from Sequence Orthology more info
involved_in chemokine (C-X-C motif) ligand 12 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in intracellular chloride ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in macrophage activation	ISO Inferred from Sequence Orthology more info
involved_in maintenance of lens transparency	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of creatine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of pancreatic juice secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of potassium ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of sodium ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ion transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of p38MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of p38MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of potassium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autophosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of blood pressure	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in renal sodium ion absorption	ISO Inferred from Sequence Orthology more info
involved_in response to aldosterone	ISO Inferred from Sequence Orthology more info
involved_in response to dietary excess	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in cell body	ISO Inferred from Sequence Orthology more info
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: STE20/SPS1-related proline-alanine-rich protein kinase

Names: PS/TK; PSTK1; Ste-20 related kinase; pancreatic serine/threonine-protein kinase; serine/threonine-protein kinase 39; ste-20-related kinase

NP_062235.1

EC 2.7.11.1

XP_008760144.1

EC 2.7.11.1

XP_063140487.1

EC 2.7.11.1

XP_063140489.1

EC 2.7.11.1

XP_063140490.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019362.1 → NP_062235.1 STE20/SPS1-related proline-alanine-rich protein kinase

See identical proteins and their annotated locations for NP_062235.1

Status: PROVISIONAL

Source sequence(s)

D88190

UniProtKB/Swiss-Prot

O70541, O88506

UniProtKB/TrEMBL

A0A8L2QHT8

Related

ENSRNOP00000089326.1, ENSRNOT00000098784.2

Conserved Domains (2) summary

smart00220
Location:72 → 346

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06610
Location:70 → 346

STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

73321522..73588397 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008761922.4 → XP_008760144.1 STE20/SPS1-related proline-alanine-rich protein kinase isoform X1

UniProtKB/TrEMBL

A0A0G2K007, A0A8L2QHT8

Related

ENSRNOP00000034162.5, ENSRNOT00000037133.7

Conserved Domains (2) summary

smart00220
Location:31 → 298

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06610
Location:31 → 298

STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase
XM_063284417.1 → XP_063140487.1 STE20/SPS1-related proline-alanine-rich protein kinase isoform X2
XM_063284419.1 → XP_063140489.1 STE20/SPS1-related proline-alanine-rich protein kinase isoform X3

UniProtKB/TrEMBL

A6HLZ1
XM_063284420.1 → XP_063140490.1 STE20/SPS1-related proline-alanine-rich protein kinase isoform X3

UniProtKB/TrEMBL

A6HLZ1