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    Relt RELT tumor necrosis factor receptor [ Mus musculus (house mouse) ]

    Gene ID: 320100, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Reltprovided by MGI
    Official Full Name
    RELT tumor necrosis factor receptorprovided by MGI
    Primary source
    MGI:MGI:2443373
    See related
    Ensembl:ENSMUSG00000008318 AllianceGenome:MGI:2443373
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tnfrsf19l; E430021K24Rik
    Summary
    Involved in amelogenesis. Predicted to be located in nucleoplasm. Is expressed in female associated reproductive structure and urethra of female. Used to study amelogenesis imperfecta type 3C. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 3C. Orthologous to human RELT (RELT TNF receptor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in spleen adult (RPKM 9.5), thymus adult (RPKM 6.5) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Relt in Genome Data Viewer
    Location:
    7 E2; 7 54.44 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (100495054..100512690, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (100845847..100863489, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35082 Neighboring gene STARR-seq mESC enhancer starr_19675 Neighboring gene STARR-seq mESC enhancer starr_19676 Neighboring gene family with sequence similarity 168, member A Neighboring gene STARR-seq mESC enhancer starr_19677 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2834 Neighboring gene STARR-positive B cell enhancer ABC_E4955 Neighboring gene Rho guanine nucleotide exchange factor 17 Neighboring gene STARR-positive B cell enhancer ABC_E8191 Neighboring gene microRNA 3102 Neighboring gene STARR-seq mESC enhancer starr_19682 Neighboring gene STARR-seq mESC enhancer starr_19683 Neighboring gene pyrimidinergic receptor P2Y, G-protein coupled, 6 Neighboring gene STARR-seq mESC enhancer starr_19684

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RELT negatively regulates the early phase of the T-cell response in mice. Choi BK, et al. Eur J Immunol, 2018 Oct. PMID 30138536
    2. Mutations in RELT cause autosomal recessive amelogenesis imperfecta. Kim JW, et al. Clin Genet, 2019 Mar. PMID 30506946, Free PMC Article
    3. Comparative analysis of apoptosis and inflammation genes of mice and humans. Reed JC, et al. Genome Res, 2003 Jun. PMID 12819136, Free PMC Article
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in amelogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amelogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in amelogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within programmed cell death RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tumor necrosis factor receptor superfamily member 19L

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358914.1 → NP_001345843.1  tumor necrosis factor receptor superfamily member 19L isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC150744
      Conserved Domains (2) summary
      cd13419
      Location:73 → 159
      TNFRSF19L; tumor necrosis factor receptor superfamily member 19-like (TNFRSF19L), also known as receptor expressed in lymphoid tissues (RELT)
      pfam12606
      Location:210 → 245
      RELT; tumor necrosis factor receptor superfamily member 19

    2. NM_177073.6 → NP_796047.2  tumor necrosis factor receptor superfamily member 19L isoform 1 precursor

      See identical proteins and their annotated locations for NP_796047.2

      Status: VALIDATED

      Source sequence(s)
      AC150744
      Consensus CDS
      CCDS21506.1
      UniProtKB/Swiss-Prot
      Q497Z8, Q8BTV0, Q8BX43
      Related
      ENSMUSP00000008462.4, ENSMUST00000008462.11
      Conserved Domains (2) summary
      cd13419
      Location:33 → 119
      TNFRSF19L; tumor necrosis factor receptor superfamily member 19-like (TNFRSF19L), also known as receptor expressed in lymphoid tissues (RELT)
      pfam12606
      Location:170 → 205
      RELT; tumor necrosis factor receptor superfamily member 19

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      100495054..100512690 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507940.5 → XP_006508003.1  tumor necrosis factor receptor superfamily member 19L isoform X3

      Conserved Domains (2) summary
      cd13419
      Location:73 → 159
      TNFRSF19L; tumor necrosis factor receptor superfamily member 19-like (TNFRSF19L), also known as receptor expressed in lymphoid tissues (RELT)
      pfam12606
      Location:210 → 245
      RELT; tumor necrosis factor receptor superfamily member 19

    2. XM_030242675.2 → XP_030098535.1  tumor necrosis factor receptor superfamily member 19L isoform X5

      Conserved Domains (2) summary
      cd13419
      Location:33 → 119
      TNFRSF19L; tumor necrosis factor receptor superfamily member 19-like (TNFRSF19L), also known as receptor expressed in lymphoid tissues (RELT)
      pfam12606
      Location:170 → 205
      RELT; tumor necrosis factor receptor superfamily member 19

    3. XM_006507939.5 → XP_006508002.1  tumor necrosis factor receptor superfamily member 19L isoform X2

      Conserved Domains (2) summary
      cd13419
      Location:73 → 159
      TNFRSF19L; tumor necrosis factor receptor superfamily member 19-like (TNFRSF19L), also known as receptor expressed in lymphoid tissues (RELT)
      pfam12606
      Location:210 → 245
      RELT; tumor necrosis factor receptor superfamily member 19

    4. XM_030242674.2 → XP_030098534.1  tumor necrosis factor receptor superfamily member 19L isoform X4

      Conserved Domains (2) summary
      cd13419
      Location:33 → 119
      TNFRSF19L; tumor necrosis factor receptor superfamily member 19-like (TNFRSF19L), also known as receptor expressed in lymphoid tissues (RELT)
      pfam12606
      Location:170 → 205
      RELT; tumor necrosis factor receptor superfamily member 19

    5. XM_006507933.3 → XP_006507996.1  tumor necrosis factor receptor superfamily member 19L isoform X1

      See identical proteins and their annotated locations for XP_006507996.1

      UniProtKB/Swiss-Prot
      Q497Z8, Q8BTV0, Q8BX43
      Conserved Domains (2) summary
      cd13419
      Location:33 → 119
      TNFRSF19L; tumor necrosis factor receptor superfamily member 19-like (TNFRSF19L), also known as receptor expressed in lymphoid tissues (RELT)
      pfam12606
      Location:170 → 205
      RELT; tumor necrosis factor receptor superfamily member 19

    6. XM_006507932.5 → XP_006507995.1  tumor necrosis factor receptor superfamily member 19L isoform X1

      See identical proteins and their annotated locations for XP_006507995.1

      UniProtKB/Swiss-Prot
      Q497Z8, Q8BTV0, Q8BX43
      Conserved Domains (2) summary
      cd13419
      Location:33 → 119
      TNFRSF19L; tumor necrosis factor receptor superfamily member 19-like (TNFRSF19L), also known as receptor expressed in lymphoid tissues (RELT)
      pfam12606
      Location:170 → 205
      RELT; tumor necrosis factor receptor superfamily member 19

    7. XM_006507935.4 → XP_006507998.1  tumor necrosis factor receptor superfamily member 19L isoform X1

      See identical proteins and their annotated locations for XP_006507998.1

      UniProtKB/Swiss-Prot
      Q497Z8, Q8BTV0, Q8BX43
      Conserved Domains (2) summary
      cd13419
      Location:33 → 119
      TNFRSF19L; tumor necrosis factor receptor superfamily member 19-like (TNFRSF19L), also known as receptor expressed in lymphoid tissues (RELT)
      pfam12606
      Location:170 → 205
      RELT; tumor necrosis factor receptor superfamily member 19

    8. XM_006507934.5 → XP_006507997.1  tumor necrosis factor receptor superfamily member 19L isoform X1

      See identical proteins and their annotated locations for XP_006507997.1

      UniProtKB/Swiss-Prot
      Q497Z8, Q8BTV0, Q8BX43
      Conserved Domains (2) summary
      cd13419
      Location:33 → 119
      TNFRSF19L; tumor necrosis factor receptor superfamily member 19-like (TNFRSF19L), also known as receptor expressed in lymphoid tissues (RELT)
      pfam12606
      Location:170 → 205
      RELT; tumor necrosis factor receptor superfamily member 19

    9. XM_006507931.5 → XP_006507994.1  tumor necrosis factor receptor superfamily member 19L isoform X1

      See identical proteins and their annotated locations for XP_006507994.1

      UniProtKB/Swiss-Prot
      Q497Z8, Q8BTV0, Q8BX43
      Conserved Domains (2) summary
      cd13419
      Location:33 → 119
      TNFRSF19L; tumor necrosis factor receptor superfamily member 19-like (TNFRSF19L), also known as receptor expressed in lymphoid tissues (RELT)
      pfam12606
      Location:170 → 205
      RELT; tumor necrosis factor receptor superfamily member 19

    10. XM_006507936.5 → XP_006507999.1  tumor necrosis factor receptor superfamily member 19L isoform X1

      See identical proteins and their annotated locations for XP_006507999.1

      UniProtKB/Swiss-Prot
      Q497Z8, Q8BTV0, Q8BX43
      Conserved Domains (2) summary
      cd13419
      Location:33 → 119
      TNFRSF19L; tumor necrosis factor receptor superfamily member 19-like (TNFRSF19L), also known as receptor expressed in lymphoid tissues (RELT)
      pfam12606
      Location:170 → 205
      RELT; tumor necrosis factor receptor superfamily member 19

    RNA

    1. XR_378249.5 RNA Sequence

    2. XR_003946489.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BX43.2 GenPept UniProtKB/Swiss-Prot:Q8BX43

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