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    Gpr149 G protein-coupled receptor 149 [ Mus musculus (house mouse) ]

    Gene ID: 229357, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gpr149provided by MGI
    Official Full Name
    G protein-coupled receptor 149provided by MGI
    Primary source
    MGI:MGI:2443628
    See related
    Ensembl:ENSMUSG00000043441 AllianceGenome:MGI:2443628
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    R35; Ieda; PGR10; 9630018L10Rik
    Summary
    Predicted to enable G protein-coupled receptor activity and neuropeptide binding activity. Acts upstream of or within antral ovarian follicle growth; negative regulation of ovulation; and preantral ovarian follicle growth. Predicted to be active in neuron projection and plasma membrane. Orthologous to human GPR149 (G protein-coupled receptor 149). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E18 (RPKM 1.6), whole brain E14.5 (RPKM 0.6) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gpr149 in Genome Data Viewer
    Location:
    3 E1; 3 29.97 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (62436851..62512861, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (62529430..62605440, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_07812 Neighboring gene Rho guanine nucleotide exchange factor 26 Neighboring gene predicted gene, 33923 Neighboring gene STARR-seq mESC enhancer starr_07813 Neighboring gene STARR-seq mESC enhancer starr_07814 Neighboring gene DEAH-box helicase 36 Neighboring gene STARR-seq mESC enhancer starr_07815 Neighboring gene STARR-seq mESC enhancer starr_07816 Neighboring gene STARR-seq mESC enhancer starr_07817 Neighboring gene STARR-seq mESC enhancer starr_07818 Neighboring gene mediator of cell motility 1 pseudogene Neighboring gene predicted gene, 40062

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The orphan G protein-coupled receptor GPR149 is a negative regulator of myelination and remyelination. Suo N, et al. Glia, 2022 Oct. PMID 35758525
    2. Gpr149 is involved in energy homeostasis in the male mouse. Wyler S, et al. PeerJ, 2024. PMID 38282864, Free PMC Article
    3. Deletion of the novel oocyte-enriched gene, Gpr149, leads to increased fertility in mice. Edson MA, et al. Endocrinology, 2010 Jan. PMID 19887567, Free PMC Article
    4. Etv1 Controls the Establishment of Non-overlapping Motor Innervation of Neighboring Facial Muscles during Development. Tenney AP, et al. Cell Rep, 2019 Oct 8. PMID 31597102, Free PMC Article
    5. The neonatal ventromedial hypothalamus transcriptome reveals novel markers with spatially distinct patterning. Kurrasch DM, et al. J Neurosci, 2007 Dec 12. PMID 18077674, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gpr149 is involved in energy homeostasis in the male mouse.
      Title: Gpr149 is involved in energy homeostasis in the male mouse.
    2. The orphan G protein-coupled receptor GPR149 is a negative regulator of myelination and remyelination.
      Title: The orphan G protein-coupled receptor GPR149 is a negative regulator of myelination and remyelination.
    3. Gpr149 null mice are one of the few models with enhanced fertility.
      Title: Deletion of the novel oocyte-enriched gene, Gpr149, leads to increased fertility in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neuropeptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within antral ovarian follicle growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within estrous cycle phase IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of ovulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within preantral ovarian follicle growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    probable G-protein coupled receptor 149
    Names
    G protein-coupled receptor PGR10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356525.1 → NP_001343454.1  probable G-protein coupled receptor 149 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC114424, AC115721
      Conserved Domains (1) summary
      cd15011
      Location:37 → 375
      7tmA_GPR149; G protein-coupled receptor 149, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_177346.5 → NP_796320.2  probable G-protein coupled receptor 149 isoform 1

      See identical proteins and their annotated locations for NP_796320.2

      Status: VALIDATED

      Source sequence(s)
      AC114424, AC115721
      Consensus CDS
      CCDS17380.1
      UniProtKB/Swiss-Prot
      Q3TMB1, Q3UVY1, Q80T52, Q8BXA3, Q8BZC0
      Related
      ENSMUSP00000060893.6, ENSMUST00000058535.6
      Conserved Domains (1) summary
      pfam00001
      Location:56 → 211
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      62436851..62512861 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240076.3 → XP_011238378.1  probable G-protein coupled receptor 149 isoform X1

      Conserved Domains (1) summary
      cd15011
      Location:37 → 375
      7tmA_GPR149; G protein-coupled receptor 149, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UVY1.1 GenPept UniProtKB/Swiss-Prot:Q3UVY1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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