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    Zfp65 zinc finger protein 65 [ Mus musculus (house mouse) ]

    Gene ID: 235907, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp65provided by MGI
    Official Full Name
    zinc finger protein 65provided by MGI
    Primary source
    MGI:MGI:107769
    See related
    Ensembl:ENSMUSG00000071281 AllianceGenome:MGI:107769
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KRAB5; pz114; Zfp71-rs1
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in central nervous system; early conceptus; head; and inner cell mass. Orthologous to human ZNF253 (zinc finger protein 253). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E18 (RPKM 1.3), whole brain E14.5 (RPKM 1.1) and 23 other tissues See more
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    Genomic context

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    See Zfp65 in Genome Data Viewer
    Location:
    13 B3; 13 34.7 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (67853428..67877238, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (67705306..67729178, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46439 Neighboring gene STARR-seq mESC enhancer starr_34906 Neighboring gene zinc finger protein 738 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:67784456-67784643 Neighboring gene STARR-seq mESC enhancer starr_34907 Neighboring gene zinc finger protein 85, opposite strand Neighboring gene STARR-seq mESC enhancer starr_34908 Neighboring gene STARR-seq mESC enhancer starr_34909 Neighboring gene STARR-seq mESC enhancer starr_34910 Neighboring gene zinc finger protein 85 Neighboring gene zinc finger protein 85, related sequence 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia. Ihle JN, et al. J Virol, 1989 Jul. PMID 2542606, Free PMC Article
    2. Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea. Bellefroid EJ, et al. Proc Natl Acad Sci U S A, 1995 Nov 7. PMID 7479878, Free PMC Article
    3. Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci. Marine JC, et al. Mamm Genome, 1996 Jun. PMID 8662221
    4. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
    5. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 71, related sequence
    Names
    zinc finger protein 71, related sequence 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001402903.1 → NP_001389832.1  zinc finger protein 71, related sequence isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT030194
      Related
      ENSMUSP00000123380.3, ENSMUST00000130891.3

    2. NM_001402904.1 → NP_001389833.1  zinc finger protein 71, related sequence isoform 1

      Status: VALIDATED

      Source sequence(s)
      CT030194
      UniProtKB/TrEMBL
      Q91W94

    3. NM_001402906.1 → NP_001389835.1  zinc finger protein 71, related sequence isoform 4

      Status: VALIDATED

      Source sequence(s)
      CT030194

    4. NM_001402907.1 → NP_001389836.1  zinc finger protein 71, related sequence isoform 4

      Status: VALIDATED

      Source sequence(s)
      CT030194

    5. NM_145622.3 → NP_663597.1  zinc finger protein 71, related sequence isoform 1

      See identical proteins and their annotated locations for NP_663597.1

      Status: VALIDATED

      Source sequence(s)
      CT030194
      Consensus CDS
      CCDS49303.1
      UniProtKB/TrEMBL
      Q91W94
      Related
      ENSMUSP00000072900.7, ENSMUST00000073157.15
      Conserved Domains (3) summary
      smart00349
      Location:5 → 62
      KRAB; krueppel associated box
      COG5048
      Location:106 → 363
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:223 → 243
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      67853428..67877238 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247250.1 → XP_030103110.1  zinc finger protein 71, related sequence isoform X3

      Conserved Domains (3) summary
      smart00349
      Location:2 → 59
      KRAB; krueppel associated box
      COG5048
      Location:103 → 360
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:220 → 240
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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