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    Dst dystonin [ Mus musculus (house mouse) ]

    Gene ID: 13518, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dstprovided by MGI
    Official Full Name
    dystoninprovided by MGI
    Primary source
    MGI:MGI:104627
    See related
    Ensembl:ENSMUSG00000026131 AllianceGenome:MGI:104627
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ah; dt; Bpag; BP230; Bpag1; Macf2; nmf203; nmf339; BPAG1-n; athetoid; mKIAA0728; 2310001O04Rik; A830042E19Rik
    Summary
    Enables protein homodimerization activity. Involved in cytoskeleton organization and retrograde axonal transport. Acts upstream of or within axonogenesis. Located in several cellular components, including cytoskeleton; endoplasmic reticulum; and sarcomere. Is active in type III intermediate filament. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and retina nuclear layer. Used to study hereditary sensory and autonomic neuropathy type 6 and hereditary sensory neuropathy. Human ortholog(s) of this gene implicated in epidermolysis bullosa simplex and hereditary sensory and autonomic neuropathy type 6. Orthologous to human DST (dystonin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 8.8), bladder adult (RPKM 7.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dst in Genome Data Viewer
    Location:
    1 B; 1 12.91 cM
    Exon count:
    113
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (33946969..34347743)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (33907888..34308662)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene 15455 Neighboring gene STARR-positive B cell enhancer ABC_E7716 Neighboring gene BEN domain containing 6 Neighboring gene predicted gene, 38471 Neighboring gene STARR-seq mESC enhancer starr_00549 Neighboring gene STARR-seq mESC enhancer starr_00551 Neighboring gene predicted gene, 53546 Neighboring gene predicted gene, 23792 Neighboring gene STARR-seq mESC enhancer starr_00553 Neighboring gene STARR-seq mESC enhancer starr_00560 Neighboring gene STARR-seq mESC enhancer starr_00563 Neighboring gene STARR-seq mESC enhancer starr_00567 Neighboring gene STARR-seq mESC enhancer starr_00573 Neighboring gene microRNA 6896 Neighboring gene predicted gene, 51742 Neighboring gene predicted gene, 26788 Neighboring gene STARR-seq mESC enhancer starr_00579 Neighboring gene 3-phosphoglycerate dehydrogenase pseudogene Neighboring gene predicted gene 3052

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The BPAG1 locus: Alternative splicing produces multiple isoforms with distinct cytoskeletal linker domains, including predominant isoforms in neurons and muscles. Leung CL, et al. J Cell Biol, 2001 Aug 20. PMID 11514586, Free PMC Article
    2. BPAG1a and b associate with EB1 and EB3 and modulate vesicular transport, Golgi apparatus structure, and cell migration in C2.7 myoblasts. Poliakova K, et al. PLoS One, 2014. PMID 25244344, Free PMC Article
    3. Disruption of actin-binding domain-containing Dystonin protein causes dystonia musculorum in mice. Horie M, et al. Eur J Neurosci, 2014 Nov. PMID 25195653
    4. An essential cytoskeletal linker protein connecting actin microfilaments to intermediate filaments. Yang Y, et al. Cell, 1996 Aug 23. PMID 8752219
    5. Pathogenesis of two axonopathies does not require axonal neurofilaments. Eyer J, et al. Nature, 1998 Feb 5. PMID 9468135

    See all (150) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The DST gene in neurobiology.
      Title: The DST gene in neurobiology.
    2. Roles of dystonin isoforms in the maintenance of neural, muscle, and cutaneous tissues.
      Title: Roles of dystonin isoforms in the maintenance of neural, muscle, and cutaneous tissues.
    3. Dystonin modifiers of junctional epidermolysis bullosa and models of epidermolysis bullosa simplex without dystonia musculorum.
      Title: Dystonin modifiers of junctional epidermolysis bullosa and models of epidermolysis bullosa simplex without dystonia musculorum.
    4. Isoform-specific mutation in Dystonin-b gene causes late-onset protein aggregate myopathy and cardiomyopathy.
      Title: Isoform-specific mutation in Dystonin-b gene causes late-onset protein aggregate myopathy and cardiomyopathy.
    5. Autoantibodies to BPAG1e Trigger Experimental Bullous Pemphigoid in Mice.
      Title: Autoantibodies to BPAG1e Trigger Experimental Bullous Pemphigoid in Mice.
    6. Dystonin loss-of-function leads to impaired autophagosome-endolysosome pathway dynamics.
      Title: Dystonin loss-of-function leads to impaired autophagosome-endolysosome pathway dynamics.
    7. Diverse dystonin gene mutations cause distinct patterns of Dst isoform deficiency and phenotypic heterogeneity in Dystonia musculorum mice.
      Title: Diverse dystonin gene mutations cause distinct patterns of Dst isoform deficiency and phenotypic heterogeneity in Dystonia musculorum mice.
    8. FLG and DST support melanoma cell growth in vitro and in vivo. Growth effects of JUP were only evident in vivo, and may be mediated, in part, by enhancing angiogenesis. In addition, growth-promoting effects of FLG and DST in vitro suggest that these genes may also support melanoma cell proliferation through angiogenesis-independent pathways.
      Title: The Barrier Molecules Junction Plakoglobin, Filaggrin, and Dystonin Play Roles in Melanoma Growth and Angiogenesis.
    9. Our finding suggests that DST alteration may involve in the mechanism of diabetic dementia
      Title: Dystonin/BPAG1 modulates diabetes and Alzheimer's disease cross-talk: a meta-analysis.
    10. Microtubule instability is not central to initiation of dystonia musculorum (Dstdt) pathogenesis, though it may contribute to disease severity. Maintenance of microtubule stability in Dstdt-Tg4 dorsal root ganglia could be attributed to an upregulation in Dst-A3 expression as a compensation for the absence of Dst-A1 and -A2 in Dstdt-Tg4 sensory neurons.
      Title: Dystonin-A3 upregulation is responsible for maintenance of tubulin acetylation in a less severe dystonia musculorum mouse model for hereditary sensory and autonomic neuropathy type VI.
    Submit: New GeneRIF Correction See all GeneRIFs (34)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule plus-end binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule plus-end binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural molecule activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hemidesmosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intermediate filament cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intermediate filament cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intracellular transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in maintenance of cell polarity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to wounding ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within retrograde axonal transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in retrograde axonal transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wound healing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in H zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in H zone IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Z disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Z disc ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell leading edge ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in hemidesmosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in hemidesmosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in hemidesmosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercalated disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in intermediate filament IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intermediate filament cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule plus-end ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule plus-end ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sarcolemma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sarcolemma IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in stress fiber IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in type III intermediate filament IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dystonin
    Names
    BPA
    dystonia musculorum protein
    hemidesmosomal plaque protein
    microtubule actin cross-linking factor 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001276764.1 → NP_001263693.1  dystonin isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC123072, AC124386, AC127433
      Consensus CDS
      CCDS69874.1
      UniProtKB/TrEMBL
      S4R1P5
      Related
      ENSMUSP00000138308.2, ENSMUST00000183034.5
      Conserved Domains (9) summary
      smart00150
      Location:786 → 877
      SPEC; Spectrin repeats
      cd00014
      Location:214 → 316
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00051
      Location:7310 → 7372
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:6488 → 6703
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:3715 → 4529
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00681
      Location:1950 → 1990
      Plectin; Plectin repeat
      pfam02187
      Location:7388 → 7461
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      pfam13499
      Location:7311 → 7371
      EF-hand_7; EF-hand domain pair
      cl02488
      Location:1371 → 1535
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    2. NM_010081.3 → NP_034211.2  dystonin isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4, also known as e) has multiple differences in the coding region and UTRs compared to variant 1. This variant encodes isoform 4 (also known as e), which has distinct N- and C-termini and is significantly shorter than isoform 1.
      Source sequence(s)
      AC127433
      Consensus CDS
      CCDS69875.1
      UniProtKB/Swiss-Prot
      Q91ZU6
      Related
      ENSMUSP00000138376.4, ENSMUST00000183302.6
      Conserved Domains (7) summary
      smart00150
      Location:282 → 373
      SPEC; Spectrin repeats
      smart00250
      Location:2504 → 2541
      PLEC; Plectin repeat
      COG1196
      Location:721 → 1477
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:375 → 563
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00681
      Location:2467 → 2506
      Plectin; Plectin repeat
      pfam09728
      Location:1399 → 1712
      Taxilin; Myosin-like coiled-coil protein
      cl02488
      Location:867 → 1031
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    3. NM_133833.4 → NP_598594.2  dystonin isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3, also known as a) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This variant also lacks seven alternate in-frame exons in the coding region. The encoded isoform (3, also known as a) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC123072, AC124386, AC127433
      Consensus CDS
      CCDS35535.1
      UniProtKB/TrEMBL
      A0A087WSP0
      Related
      ENSMUSP00000095393.3, ENSMUST00000097786.10
      Conserved Domains (8) summary
      smart00150
      Location:608 → 699
      SPEC; Spectrin repeats
      cd00014
      Location:36 → 138
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00051
      Location:5009 → 5071
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:4187 → 4402
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:1480 → 2337
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam02187
      Location:5087 → 5160
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      pfam13499
      Location:5010 → 5070
      EF-hand_7; EF-hand domain pair
      cl02488
      Location:1193 → 1357
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    4. NM_134448.4 → NP_604443.2  dystonin isoform 2

      See identical proteins and their annotated locations for NP_604443.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2, also known as b) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This variant also lacks two alternate in-frame exons in the coding region. The encoded isoform (2, also known as b) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC123072, AC124386, AC127433
      Consensus CDS
      CCDS35534.1
      UniProtKB/Swiss-Prot
      E9PXE5, E9QL23, Q1KP04, Q3I6J6, Q60824, Q60845, Q8K5D4, Q91ZU6, Q91ZU7, Q91ZU8, Q9WU50, S4R1U5
      Related
      ENSMUSP00000095392.3, ENSMUST00000097785.10
      Conserved Domains (9) summary
      smart00150
      Location:608 → 699
      SPEC; Spectrin repeats
      cd00014
      Location:36 → 138
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00051
      Location:7023 → 7085
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:6201 → 6416
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:3537 → 4351
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00681
      Location:1772 → 1812
      Plectin; Plectin repeat
      pfam02187
      Location:7101 → 7174
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      pfam13499
      Location:7024 → 7084
      EF-hand_7; EF-hand domain pair
      cl02488
      Location:1193 → 1357
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      33946969..34347743
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006495666.4 → XP_006495729.1  dystonin isoform X3

      Conserved Domains (12) summary
      pfam05483
      Location:1261 → 1451
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      smart00150
      Location:786 → 877
      SPEC; Spectrin repeats
      COG1196
      Location:4346 → 5241
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5069
      Location:208 → 432
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00051
      Location:7311 → 7373
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:6489 → 6704
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:3662 → 4440
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:1285 → 1723
      CCDC158; Coiled-coil domain-containing protein 158
      pfam00681
      Location:1951 → 1991
      Plectin; Plectin repeat
      pfam02187
      Location:7388 → 7462
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      pfam17902
      Location:1054 → 1120
      SH3_10; SH3 domain
      pfam18373
      Location:1155 → 1232
      Spectrin_like; Spectrin like domain

    2. XM_006495690.4 → XP_006495753.1  dystonin isoform X34

      Conserved Domains (12) summary
      pfam05483
      Location:1261 → 1451
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      smart00243
      Location:7386 → 7458
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      smart00150
      Location:786 → 877
      SPEC; Spectrin repeats
      COG1196
      Location:4346 → 5241
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5069
      Location:208 → 432
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00051
      Location:7311 → 7373
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:6489 → 6704
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:3662 → 4440
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:1285 → 1723
      CCDC158; Coiled-coil domain-containing protein 158
      pfam00681
      Location:1951 → 1991
      Plectin; Plectin repeat
      pfam17902
      Location:1054 → 1120
      SH3_10; SH3 domain
      pfam18373
      Location:1155 → 1232
      Spectrin_like; Spectrin like domain

    3. XM_006495691.4 → XP_006495754.1  dystonin isoform X33

      Conserved Domains (12) summary
      pfam05483
      Location:1261 → 1451
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      smart00243
      Location:7277 → 7355
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      smart00150
      Location:786 → 877
      SPEC; Spectrin repeats
      COG1196
      Location:4346 → 5241
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5069
      Location:208 → 432
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00051
      Location:7202 → 7264
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:6380 → 6595
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:3662 → 4440
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:1285 → 1723
      CCDC158; Coiled-coil domain-containing protein 158
      pfam00681
      Location:1951 → 1991
      Plectin; Plectin repeat
      pfam17902
      Location:1054 → 1120
      SH3_10; SH3 domain
      pfam18373
      Location:1155 → 1232
      Spectrin_like; Spectrin like domain

    4. XM_036158508.1 → XP_036014401.1  dystonin isoform X23

      UniProtKB/TrEMBL
      A0A087WSP0
      Conserved Domains (11) summary
      smart00150
      Location:786 → 877
      SPEC; Spectrin repeats
      COG1196
      Location:2332 → 3227
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00051
      Location:5297 → 5359
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:4475 → 4690
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:1659 → 2516
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:1385 → 1811
      CCDC158; Coiled-coil domain-containing protein 158
      pfam02187
      Location:5374 → 5448
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      pfam17902
      Location:1054 → 1120
      SH3_10; SH3 domain
      pfam18373
      Location:1155 → 1232
      Spectrin_like; Spectrin like domain
      cd21236
      Location:201 → 325
      CH_DYST_rpt1; first calponin homology (CH) domain found in dystonin and similar proteins
      cd21239
      Location:330 → 433
      CH_DYST_rpt2; second calponin homology (CH) domain found in dystonin and similar proteins

    5. XM_006495682.3 → XP_006495745.1  dystonin isoform X24

      UniProtKB/TrEMBL
      A0A087WSP0
      Conserved Domains (11) summary
      pfam05483
      Location:1261 → 1451
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      smart00150
      Location:786 → 877
      SPEC; Spectrin repeats
      COG1196
      Location:2332 → 3227
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5069
      Location:208 → 432
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00051
      Location:5297 → 5359
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:4475 → 4690
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:1659 → 2516
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl02488
      Location:1372 → 1536
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam02187
      Location:5374 → 5448
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      pfam17902
      Location:1054 → 1120
      SH3_10; SH3 domain
      pfam18373
      Location:1155 → 1232
      Spectrin_like; Spectrin like domain

    6. XM_017314621.2 → XP_017170110.1  dystonin isoform X1

      Conserved Domains (12) summary
      pfam05483
      Location:1273 → 1463
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      smart00150
      Location:798 → 889
      SPEC; Spectrin repeats
      COG1196
      Location:4358 → 5253
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5069
      Location:208 → 444
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00051
      Location:7323 → 7385
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:6501 → 6716
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:3674 → 4452
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:1297 → 1735
      CCDC158; Coiled-coil domain-containing protein 158
      pfam00681
      Location:1963 → 2003
      Plectin; Plectin repeat
      pfam02187
      Location:7400 → 7474
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      pfam17902
      Location:1066 → 1132
      SH3_10; SH3 domain
      pfam18373
      Location:1167 → 1244
      Spectrin_like; Spectrin like domain

    7. XM_017314676.2 → XP_017170165.1  dystonin isoform X6

      Conserved Domains (12) summary
      pfam05483
      Location:1273 → 1463
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      smart00150
      Location:798 → 889
      SPEC; Spectrin repeats
      COG1196
      Location:4358 → 5253
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5069
      Location:208 → 444
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00051
      Location:7323 → 7385
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:6501 → 6716
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:3674 → 4452
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:1297 → 1735
      CCDC158; Coiled-coil domain-containing protein 158
      pfam00681
      Location:1963 → 2003
      Plectin; Plectin repeat
      pfam02187
      Location:7400 → 7474
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      pfam17902
      Location:1066 → 1132
      SH3_10; SH3 domain
      pfam18373
      Location:1167 → 1244
      Spectrin_like; Spectrin like domain

    8. XM_017314651.2 → XP_017170140.1  dystonin isoform X4

      Conserved Domains (12) summary
      pfam05483
      Location:1273 → 1463
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      smart00243
      Location:7398 → 7476
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      smart00150
      Location:798 → 889
      SPEC; Spectrin repeats
      COG1196
      Location:4358 → 5253
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5069
      Location:208 → 444
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00051
      Location:7323 → 7385
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:6501 → 6716
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:3674 → 4452
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:1297 → 1735
      CCDC158; Coiled-coil domain-containing protein 158
      pfam00681
      Location:1963 → 2003
      Plectin; Plectin repeat
      pfam17902
      Location:1066 → 1132
      SH3_10; SH3 domain
      pfam18373
      Location:1167 → 1244
      Spectrin_like; Spectrin like domain

    9. XM_017314687.2 → XP_017170176.1  dystonin isoform X8

      Conserved Domains (12) summary
      pfam05483
      Location:1273 → 1463
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      smart00243
      Location:7398 → 7476
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      smart00150
      Location:798 → 889
      SPEC; Spectrin repeats
      COG1196
      Location:4358 → 5253
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5069
      Location:208 → 444
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00051
      Location:7323 → 7385
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:6501 → 6716
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:3674 → 4452
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:1297 → 1735
      CCDC158; Coiled-coil domain-containing protein 158
      pfam00681
      Location:1963 → 2003
      Plectin; Plectin repeat
      pfam17902
      Location:1066 → 1132
      SH3_10; SH3 domain
      pfam18373
      Location:1167 → 1244
      Spectrin_like; Spectrin like domain

    10. XM_017314635.2 → XP_017170124.1  dystonin isoform X2

      Conserved Domains (12) summary
      pfam05483
      Location:1273 → 1463
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      smart00150
      Location:798 → 889
      SPEC; Spectrin repeats
      COG1196
      Location:4358 → 5253
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5069
      Location:208 → 444
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00051
      Location:7323 → 7385
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:6501 → 6716
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:3674 → 4452
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:1297 → 1735
      CCDC158; Coiled-coil domain-containing protein 158
      pfam00681
      Location:1963 → 2003
      Plectin; Plectin repeat
      pfam02187
      Location:7400 → 7468
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      pfam17902
      Location:1066 → 1132
      SH3_10; SH3 domain
      pfam18373
      Location:1167 → 1244
      Spectrin_like; Spectrin like domain

    11. XM_030246500.1 → XP_030102360.1  dystonin isoform X7

      Conserved Domains (12) summary
      pfam05483
      Location:1273 → 1463
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      smart00150
      Location:798 → 889
      SPEC; Spectrin repeats
      COG1196
      Location:4358 → 5253
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5069
      Location:208 → 444
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00051
      Location:7323 → 7385
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:6501 → 6716
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:3674 → 4452
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:1297 → 1735
      CCDC158; Coiled-coil domain-containing protein 158
      pfam00681
      Location:1963 → 2003
      Plectin; Plectin repeat
      pfam02187
      Location:7400 → 7468
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      pfam17902
      Location:1066 → 1132
      SH3_10; SH3 domain
      pfam18373
      Location:1167 → 1244
      Spectrin_like; Spectrin like domain

    12. XM_017314665.2 → XP_017170154.1  dystonin isoform X5

      Conserved Domains (12) summary
      pfam05483
      Location:1273 → 1463
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      smart00243
      Location:7398 → 7470
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      smart00150
      Location:798 → 889
      SPEC; Spectrin repeats
      COG1196
      Location:4358 → 5253
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5069
      Location:208 → 444
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00051
      Location:7323 → 7385
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:6501 → 6716
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:3674 → 4452
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:1297 → 1735
      CCDC158; Coiled-coil domain-containing protein 158
      pfam00681
      Location:1963 → 2003
      Plectin; Plectin repeat
      pfam17902
      Location:1066 → 1132
      SH3_10; SH3 domain
      pfam18373
      Location:1167 → 1244
      Spectrin_like; Spectrin like domain

    13. XM_017314706.2 → XP_017170195.1  dystonin isoform X11

      Conserved Domains (12) summary
      pfam05483
      Location:1273 → 1463
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      smart00150
      Location:798 → 889
      SPEC; Spectrin repeats
      COG1196
      Location:4358 → 5253
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5069
      Location:208 → 444
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00051
      Location:7214 → 7276
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:6392 → 6607
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:3674 → 4452
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:1297 → 1735
      CCDC158; Coiled-coil domain-containing protein 158
      pfam00681
      Location:1963 → 2003
      Plectin; Plectin repeat
      pfam02187
      Location:7291 → 7365
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      pfam17902
      Location:1066 → 1132
      SH3_10; SH3 domain
      pfam18373
      Location:1167 → 1244
      Spectrin_like; Spectrin like domain

    14. XM_017314722.2 → XP_017170211.1  dystonin isoform X14

      Conserved Domains (12) summary
      pfam05483
      Location:1273 → 1463
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      smart00150
      Location:798 → 889
      SPEC; Spectrin repeats
      COG1196
      Location:4358 → 5253
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5069
      Location:208 → 444
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00051
      Location:7214 → 7276
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:6392 → 6607
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:3674 → 4452
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:1297 → 1735
      CCDC158; Coiled-coil domain-containing protein 158
      pfam00681
      Location:1963 → 2003
      Plectin; Plectin repeat
      pfam02187
      Location:7291 → 7365
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      pfam17902
      Location:1066 → 1132
      SH3_10; SH3 domain
      pfam18373
      Location:1167 → 1244
      Spectrin_like; Spectrin like domain

    15. XM_017314794.2 → XP_017170283.1  dystonin isoform X22

      UniProtKB/TrEMBL
      A0A087WSP0
      Conserved Domains (11) summary
      pfam05483
      Location:1273 → 1463
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      smart00150
      Location:798 → 889
      SPEC; Spectrin repeats
      COG1196
      Location:2344 → 3239
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5069
      Location:208 → 444
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00051
      Location:5309 → 5371
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:4487 → 4702
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:1671 → 2528
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl02488
      Location:1384 → 1548
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam02187
      Location:5386 → 5460
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      pfam17902
      Location:1066 → 1132
      SH3_10; SH3 domain
      pfam18373
      Location:1167 → 1244
      Spectrin_like; Spectrin like domain

    16. XM_017314811.2 → XP_017170300.1  dystonin isoform X25

      UniProtKB/TrEMBL
      A0A087WSP0
      Conserved Domains (11) summary
      pfam05483
      Location:1273 → 1463
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      smart00150
      Location:798 → 889
      SPEC; Spectrin repeats
      COG1196
      Location:2344 → 3239
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5069
      Location:208 → 444
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00051
      Location:5200 → 5262
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:4378 → 4593
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:1671 → 2528
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl02488
      Location:1384 → 1548
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam02187
      Location:5277 → 5351
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      pfam17902
      Location:1066 → 1132
      SH3_10; SH3 domain
      pfam18373
      Location:1167 → 1244
      Spectrin_like; Spectrin like domain

    17. XM_017314689.2 → XP_017170178.1  dystonin isoform X9

      Conserved Domains (12) summary
      pfam05483
      Location:1273 → 1463
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      smart00243
      Location:7398 → 7470
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      smart00150
      Location:798 → 889
      SPEC; Spectrin repeats
      COG1196
      Location:4358 → 5253
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5069
      Location:208 → 444
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00051
      Location:7323 → 7385
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:6501 → 6716
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:3674 → 4452
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:1297 → 1735
      CCDC158; Coiled-coil domain-containing protein 158
      pfam00681
      Location:1963 → 2003
      Plectin; Plectin repeat
      pfam17902
      Location:1066 → 1132
      SH3_10; SH3 domain
      pfam18373
      Location:1167 → 1244
      Spectrin_like; Spectrin like domain

    18. XM_017314716.3 → XP_017170205.1  dystonin isoform X13

      Conserved Domains (12) summary
      pfam05483
      Location:1135 → 1325
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      smart00150
      Location:660 → 751
      SPEC; Spectrin repeats
      COG1196
      Location:4220 → 5115
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5069
      Location:70 → 306
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00051
      Location:7185 → 7247
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:6363 → 6578
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:3536 → 4314
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:1159 → 1597
      CCDC158; Coiled-coil domain-containing protein 158
      pfam00681
      Location:1825 → 1865
      Plectin; Plectin repeat
      pfam02187
      Location:7262 → 7336
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      pfam17902
      Location:928 → 994
      SH3_10; SH3 domain
      pfam18373
      Location:1029 → 1106
      Spectrin_like; Spectrin like domain

    19. XM_006495674.5 → XP_006495737.1  dystonin isoform X15

      Conserved Domains (12) summary
      pfam05483
      Location:1123 → 1313
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      smart00150
      Location:648 → 739
      SPEC; Spectrin repeats
      COG1196
      Location:4208 → 5103
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5069
      Location:70 → 294
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00051
      Location:7173 → 7235
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:6351 → 6566
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:3524 → 4302
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:1147 → 1585
      CCDC158; Coiled-coil domain-containing protein 158
      pfam00681
      Location:1813 → 1853
      Plectin; Plectin repeat
      pfam02187
      Location:7250 → 7324
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      pfam17902
      Location:916 → 982
      SH3_10; SH3 domain
      pfam18373
      Location:1017 → 1094
      Spectrin_like; Spectrin like domain

    20. XM_017314712.3 → XP_017170201.1  dystonin isoform X12

      Conserved Domains (12) summary
      pfam05483
      Location:1139 → 1329
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      smart00150
      Location:664 → 755
      SPEC; Spectrin repeats
      COG1196
      Location:4224 → 5119
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5069
      Location:74 → 310
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00051
      Location:7189 → 7251
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:6367 → 6582
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:3540 → 4318
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:1163 → 1601
      CCDC158; Coiled-coil domain-containing protein 158
      pfam00681
      Location:1829 → 1869
      Plectin; Plectin repeat
      pfam02187
      Location:7266 → 7340
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      pfam17902
      Location:932 → 998
      SH3_10; SH3 domain
      pfam18373
      Location:1033 → 1110
      Spectrin_like; Spectrin like domain

    21. XM_017314741.2 → XP_017170230.1  dystonin isoform X16

      Conserved Domains (12) summary
      pfam05483
      Location:1095 → 1285
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      smart00150
      Location:620 → 711
      SPEC; Spectrin repeats
      COG1196
      Location:4180 → 5075
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5069
      Location:35 → 266
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00051
      Location:7145 → 7207
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:6323 → 6538
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:3496 → 4274
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:1119 → 1557
      CCDC158; Coiled-coil domain-containing protein 158
      pfam00681
      Location:1785 → 1825
      Plectin; Plectin repeat
      pfam02187
      Location:7222 → 7296
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      pfam17902
      Location:888 → 954
      SH3_10; SH3 domain
      pfam18373
      Location:989 → 1066
      Spectrin_like; Spectrin like domain

    22. XM_006495678.4 → XP_006495741.1  dystonin isoform X18

      Conserved Domains (12) summary
      pfam05483
      Location:1083 → 1273
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      smart00150
      Location:608 → 699
      SPEC; Spectrin repeats
      COG1196
      Location:4168 → 5063
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5069
      Location:35 → 254
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00051
      Location:7133 → 7195
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:6311 → 6526
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:3484 → 4262
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:1107 → 1545
      CCDC158; Coiled-coil domain-containing protein 158
      pfam00681
      Location:1773 → 1813
      Plectin; Plectin repeat
      pfam02187
      Location:7210 → 7284
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      pfam17902
      Location:876 → 942
      SH3_10; SH3 domain
      pfam18373
      Location:977 → 1054
      Spectrin_like; Spectrin like domain

    23. XM_006495688.4 → XP_006495751.1  dystonin isoform X32

      Conserved Domains (12) summary
      pfam05483
      Location:1083 → 1273
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      smart00150
      Location:608 → 699
      SPEC; Spectrin repeats
      COG1196
      Location:4168 → 5063
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5069
      Location:35 → 254
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00051
      Location:7133 → 7195
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:6311 → 6526
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:3484 → 4262
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:1107 → 1545
      CCDC158; Coiled-coil domain-containing protein 158
      pfam00681
      Location:1773 → 1813
      Plectin; Plectin repeat
      pfam02187
      Location:7210 → 7284
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      pfam17902
      Location:876 → 942
      SH3_10; SH3 domain
      pfam18373
      Location:977 → 1054
      Spectrin_like; Spectrin like domain

    24. XM_017314848.2 → XP_017170337.1  dystonin isoform X31

      Conserved Domains (12) summary
      pfam05483
      Location:1083 → 1273
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      smart00150
      Location:608 → 699
      SPEC; Spectrin repeats
      COG1196
      Location:4168 → 5063
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5069
      Location:35 → 254
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00051
      Location:7024 → 7086
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:6202 → 6417
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:3484 → 4262
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:1107 → 1545
      CCDC158; Coiled-coil domain-containing protein 158
      pfam00681
      Location:1773 → 1813
      Plectin; Plectin repeat
      pfam02187
      Location:7101 → 7175
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      pfam17902
      Location:876 → 942
      SH3_10; SH3 domain
      pfam18373
      Location:977 → 1054
      Spectrin_like; Spectrin like domain

    25. XM_006495684.4 → XP_006495747.1  dystonin isoform X26

      UniProtKB/TrEMBL
      A0A087WSP0
      Conserved Domains (11) summary
      pfam05483
      Location:1083 → 1273
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      smart00150
      Location:608 → 699
      SPEC; Spectrin repeats
      COG1196
      Location:2154 → 3049
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5069
      Location:35 → 254
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00051
      Location:5119 → 5181
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:4297 → 4512
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:1481 → 2338
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl02488
      Location:1194 → 1358
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam02187
      Location:5196 → 5270
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      pfam17902
      Location:876 → 942
      SH3_10; SH3 domain
      pfam18373
      Location:977 → 1054
      Spectrin_like; Spectrin like domain

    26. XM_036158554.1 → XP_036014447.1  dystonin isoform X27

      UniProtKB/TrEMBL
      A0A087WSP0
      Conserved Domains (11) summary
      smart00243
      Location:5194 → 5266
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      smart00150
      Location:608 → 699
      SPEC; Spectrin repeats
      COG1196
      Location:2154 → 3049
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00051
      Location:5119 → 5181
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:4297 → 4512
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:1481 → 2338
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:1207 → 1633
      CCDC158; Coiled-coil domain-containing protein 158
      pfam17902
      Location:876 → 942
      SH3_10; SH3 domain
      pfam18373
      Location:977 → 1054
      Spectrin_like; Spectrin like domain
      cd21236
      Location:20 → 147
      CH_DYST_rpt1; first calponin homology (CH) domain found in dystonin and similar proteins
      cd21239
      Location:152 → 255
      CH_DYST_rpt2; second calponin homology (CH) domain found in dystonin and similar proteins

    27. XM_017314868.2 → XP_017170357.1  dystonin isoform X28

      UniProtKB/TrEMBL
      A0A087WSP0
      Conserved Domains (11) summary
      pfam05483
      Location:1083 → 1273
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      smart00150
      Location:608 → 699
      SPEC; Spectrin repeats
      COG1196
      Location:2154 → 3049
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5069
      Location:35 → 254
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00051
      Location:5010 → 5072
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:4188 → 4403
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:1481 → 2338
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl02488
      Location:1194 → 1358
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam02187
      Location:5087 → 5161
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      pfam17902
      Location:876 → 942
      SH3_10; SH3 domain
      pfam18373
      Location:977 → 1054
      Spectrin_like; Spectrin like domain

    28. XM_017314750.3 → XP_017170239.1  dystonin isoform X17

      Conserved Domains (12) summary
      pfam05483
      Location:1088 → 1278
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      smart00150
      Location:613 → 704
      SPEC; Spectrin repeats
      COG1196
      Location:4173 → 5068
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5069
      Location:28 → 259
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00051
      Location:7138 → 7200
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:6316 → 6531
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:3489 → 4267
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:1112 → 1550
      CCDC158; Coiled-coil domain-containing protein 158
      pfam00681
      Location:1778 → 1818
      Plectin; Plectin repeat
      pfam02187
      Location:7215 → 7289
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      pfam17902
      Location:881 → 947
      SH3_10; SH3 domain
      pfam18373
      Location:982 → 1059
      Spectrin_like; Spectrin like domain

    29. XM_006495679.4 → XP_006495742.1  dystonin isoform X19

      Conserved Domains (12) summary
      pfam05483
      Location:996 → 1186
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      smart00150
      Location:521 → 612
      SPEC; Spectrin repeats
      COG1196
      Location:4081 → 4976
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5069
      Location:1 → 167
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00051
      Location:7046 → 7108
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:6224 → 6439
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:3397 → 4175
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:1020 → 1458
      CCDC158; Coiled-coil domain-containing protein 158
      pfam00681
      Location:1686 → 1726
      Plectin; Plectin repeat
      pfam02187
      Location:7123 → 7197
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      pfam17902
      Location:789 → 855
      SH3_10; SH3 domain
      pfam18373
      Location:890 → 967
      Spectrin_like; Spectrin like domain

    30. XM_006495669.5 → XP_006495732.1  dystonin isoform X10

      Conserved Domains (12) summary
      pfam05483
      Location:1199 → 1389
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      smart00150
      Location:724 → 815
      SPEC; Spectrin repeats
      COG1196
      Location:4284 → 5179
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00014
      Location:268 → 371
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00051
      Location:7249 → 7311
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:6427 → 6642
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:3600 → 4378
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:1223 → 1661
      CCDC158; Coiled-coil domain-containing protein 158
      pfam00681
      Location:1889 → 1929
      Plectin; Plectin repeat
      pfam02187
      Location:7326 → 7400
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      pfam17902
      Location:992 → 1058
      SH3_10; SH3 domain
      pfam18373
      Location:1093 → 1170
      Spectrin_like; Spectrin like domain

    31. XM_006495686.5 → XP_006495749.1  dystonin isoform X30

      Conserved Domains (8) summary
      smart00150
      Location:282 → 373
      SPEC; Spectrin repeats
      smart00250
      Location:2505 → 2542
      PLEC; Plectin repeat
      COG1196
      Location:678 → 1404
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:375 → 564
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:1098 → 1859
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00681
      Location:2468 → 2507
      Plectin; Plectin repeat
      pfam17902
      Location:550 → 616
      SH3_10; SH3 domain
      pfam18373
      Location:651 → 728
      Spectrin_like; Spectrin like domain

    32. XM_006495680.5 → XP_006495743.1  dystonin isoform X20

      Conserved Domains (11) summary
      pfam05483
      Location:757 → 947
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      smart00150
      Location:282 → 373
      SPEC; Spectrin repeats
      COG1196
      Location:3842 → 4737
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00051
      Location:6807 → 6869
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:5985 → 6200
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:3158 → 3936
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:781 → 1219
      CCDC158; Coiled-coil domain-containing protein 158
      pfam00681
      Location:1447 → 1487
      Plectin; Plectin repeat
      pfam02187
      Location:6884 → 6958
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      pfam17902
      Location:550 → 616
      SH3_10; SH3 domain
      pfam18373
      Location:651 → 728
      Spectrin_like; Spectrin like domain

    33. XM_006495685.2 → XP_006495748.1  dystonin isoform X29

      UniProtKB/TrEMBL
      A0A087WSP0
      Related
      ENSMUSP00000141127.2, ENSMUST00000185269.7
      Conserved Domains (10) summary
      pfam05483
      Location:757 → 947
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      smart00150
      Location:282 → 373
      SPEC; Spectrin repeats
      COG1196
      Location:1828 → 2723
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00051
      Location:4793 → 4855
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:3971 → 4186
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:1155 → 2012
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl02488
      Location:868 → 1032
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam02187
      Location:4870 → 4944
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      pfam17902
      Location:550 → 616
      SH3_10; SH3 domain
      pfam18373
      Location:651 → 728
      Spectrin_like; Spectrin like domain

    34. XM_030246701.2 → XP_030102561.1  dystonin isoform X21

      Conserved Domains (7) summary
      smart00150
      Location:5322 → 5449
      SPEC; Spectrin repeats
      COG1196
      Location:2518 → 3413
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00051
      Location:5483 → 5545
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:4661 → 4876
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:1834 → 2612
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00681
      Location:123 → 163
      Plectin; Plectin repeat
      pfam02187
      Location:5560 → 5634
      GAS2; Growth-Arrest-Specific Protein 2 Domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91ZU6.2 GenPept UniProtKB/Swiss-Prot:Q91ZU6

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