H2-DMb1 histocompatibility 2, class II, locus Mb1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: H2-DMb1provided by MGI
Official Full Name: histocompatibility 2, class II, locus Mb1provided by MGI
Primary source: MGI:MGI:95922
See related: Ensembl:ENSMUSG00000079547 AllianceGenome:MGI:95922
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: H-2Mb1; H2-Mb1
Summary: Predicted to enable MHC class II protein complex binding activity and peptide antigen binding activity. Acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II and chaperone cofactor-dependent protein refolding. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be part of MHC class II protein complex. Predicted to be active in late endosome membrane and lysosomal membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human HLA-DMB (major histocompatibility complex, class II, DM beta). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in spleen adult (RPKM 164.1), large intestine adult (RPKM 97.0) and 11 other tissues See more
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Genomic context

Location:: 17 B1; 17 17.98 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (34372165..34379203)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (34153191..34160229)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI385589 (e-PCR)
- UniSTS:180997

Ms10s (e-PCR), detects polymorphism
- UniSTS:234003

H2-DMb1 (e-PCR), detects polymorphism
- UniSTS:526916

H2-DMb1 (e-PCR), detects polymorphism
- UniSTS:143303

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables MHC class II protein complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables MHC class II protein complex binding	ISO Inferred from Sequence Orthology more info
enables MHC class II protein complex binding	ISS Inferred from Sequence or Structural Similarity more info
enables peptide antigen binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in MHC class II protein complex assembly	ISO Inferred from Sequence Orthology more info
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within antigen processing and presentation	IDA Inferred from Direct Assay more info	PubMed
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class II	IDA Inferred from Direct Assay more info	PubMed
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chaperone cofactor-dependent protein refolding	IDA Inferred from Direct Assay more info	PubMed
involved_in peptide antigen assembly with MHC class II protein complex	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptide antigen assembly with MHC class II protein complex	ISO Inferred from Sequence Orthology more info
involved_in peptide antigen assembly with MHC class II protein complex	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of T cell activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of immune response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of MHC class II protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MHC class II protein complex	IEA Inferred from Electronic Annotation more info
part_of MHC class II protein complex	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in late endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in late endosome membrane	ISO Inferred from Sequence Orthology more info
located_in late endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: class II histocompatibility antigen, M beta 1 chain

Names: H2-M beta 1 chain; H2-M beta1; MHC class II antigen Mb1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010387.3 → NP_034517.2 class II histocompatibility antigen, M beta 1 chain precursor

See identical proteins and their annotated locations for NP_034517.2

Status: VALIDATED

Source sequence(s)

AK032745

Consensus CDS

CCDS37581.1

UniProtKB/TrEMBL

Q31094, Q31111, Q31631

Related

ENSMUSP00000109870.3, ENSMUST00000114232.4

Conserved Domains (3) summary

smart00410
Location:129 → 201

IG_like; Immunoglobulin like

pfam00969
Location:27 → 106

MHC_II_beta; Class II histocompatibility antigen, beta domain

cl11960
Location:115 → 209

Ig; Immunoglobulin domain