Tmem35a transmembrane protein 35A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmem35aprovided by MGI
Official Full Name: transmembrane protein 35Aprovided by MGI
Primary source: MGI:MGI:1914814
See related: Ensembl:ENSMUSG00000033578 AllianceGenome:MGI:1914814
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NACHO; PMP52; Tmem35; 9030603L14Rik
Summary: Enables acetylcholine receptor regulator activity. Involved in chaperone-mediated protein complex assembly and positive regulation of protein localization to cell surface. Located in endoplasmic reticulum. Is expressed in adrenal gland; maturing glomerular tuft; nervous system; neural retina; and testis. Orthologous to human TMEM35A (transmembrane protein 35A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in adrenal adult (RPKM 56.0), CNS E18 (RPKM 27.5) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: X E3; X 56.06 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (133195974..133206718)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (134295225..134305969)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The nAChR Chaperone TMEM35a (NACHO) Contributes to the Development of Hyperalgesia in Mice.
Title: The nAChR Chaperone TMEM35a (NACHO) Contributes to the Development of Hyperalgesia in Mice.
NACHO Engages N-Glycosylation ER Chaperone Pathways for alpha7 Nicotinic Receptor Assembly.
Title: NACHO Engages N-Glycosylation ER Chaperone Pathways for α7 Nicotinic Receptor Assembly.
Why Does Knocking Out NACHO, But Not RIC3, Completely Block Expression of alpha7 Nicotinic Receptors in Mouse Brain?
Title: Why Does Knocking Out NACHO, But Not RIC3, Completely Block Expression of α7 Nicotinic Receptors in Mouse Brain?
Pathway analysis of differentially expressed synaptic proteins in tmem35 KO hippocampus implicated molecular networks associated with specific cellular and behavioral functions, including decreased long-term potentiation, and increased startle reactivity
Title: Deletion of novel protein TMEM35 alters stress-related functions and impairs long-term memory in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acetylcholine receptor regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetylcholine receptor regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables acetylcholine receptor regulator activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chaperone-mediated protein complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in chaperone-mediated protein complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chaperone-mediated protein complex assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to cell surface	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein localization to cell surface	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to cell surface	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in peroxisomal membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: novel acetylcholine receptor chaperone

Names: peroxisomal membrane protein 52; transmembrane protein 35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.