Tas2r107 taste receptor, type 2, member 107 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tas2r107provided by MGI
Official Full Name: taste receptor, type 2, member 107provided by MGI
Primary source: MGI:MGI:2681207
See related: Ensembl:ENSMUSG00000053389 AllianceGenome:MGI:2681207
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: T2R4; T2R07; mGR06; STC5-1; T2R107; Tas2r7; mt2r43
Summary: Predicted to enable bitter taste receptor activity. Predicted to be involved in detection of chemical stimulus involved in sensory perception of bitter taste. Predicted to be active in membrane. Orthologous to human TAS2R10 (taste 2 receptor member 10). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: 6 F3; 6 63.49 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (131636081..131637112, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (131659118..131660149, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that Tas2r107 is expressed on murine airway smooth muscle (ASM) cells; Tas2r107 agonists reverse bronchoconstriction by inhibiting agonist-induced calcium oscillations while simultaneously reducing calcium sensitivity of ASM cells.
Title: Bitter tasting compounds dilate airways by inhibiting airway smooth muscle calcium oscillations and calcium sensitivity.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:493160

NoName (e-PCR)
- UniSTS:495726

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables bitter taste receptor activity	IEA Inferred from Electronic Annotation more info
enables bitter taste receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in detection of chemical stimulus involved in sensory perception of bitter taste	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within detection of chemical stimulus involved in sensory perception of bitter taste	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: taste receptor type 2 member 107

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199154.2 → NP_954605.1 taste receptor type 2 member 107

Status: VALIDATED

Source sequence(s)

AC140204

Consensus CDS

CCDS20609.1

UniProtKB/Swiss-Prot

Q71QD3, Q7M725

UniProtKB/TrEMBL

B2RU97

Related

ENSMUSP00000067082.5, ENSMUST00000065781.5

Conserved Domains (1) summary

pfam05296
Location:1 → 297

TAS2R; Taste receptor protein (TAS2R)