Mup2 major urinary protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mup2provided by MGI
Official Full Name: major urinary protein 2provided by MGI
Primary source: MGI:MGI:97234
See related: Ensembl:ENSMUSG00000078688 AllianceGenome:MGI:97234
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mup4; Mup-2; Mup18
Summary: Predicted to enable insulin receptor activity and pheromone binding activity. Predicted to be involved in several processes, including regulation of gene expression; regulation of glucose metabolic process; and regulation of lipid metabolic process. Located in extracellular space. Is expressed in frontal bone primordium and palatal shelf. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward liver adult (RPKM 2244.8) See more
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Genomic context

Location:: 4 B3; 4 32.83 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (60135913..60139977, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (60135913..60139977, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these results indicate that Mup2 expression is regulated by both the circadian clock and glucocorticoid.
Title: Identification of transcriptional regulatory elements required for the Mup2 expression in circadian clock mutant mice.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables insulin receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables molecular_function	ND No biological Data available more info
enables odorant binding	IBA Inferred from Biological aspect of Ancestor more info
enables pheromone binding	ISS Inferred from Sequence or Structural Similarity more info
enables small molecule binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in aerobic respiration	ISS Inferred from Sequence or Structural Similarity more info
involved_in biological_process	ND No biological Data available more info
involved_in cellular response to lipid	ISS Inferred from Sequence or Structural Similarity more info
involved_in energy reserve metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in glucose homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in heat generation	ISS Inferred from Sequence or Structural Similarity more info
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in locomotor rhythm	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrion organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of gluconeogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of lipid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of lipid storage	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of glucose metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of lipid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: major urinary protein 2

Names: 2610016E04Rik; major urinary protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045550.2 → NP_001039015.1 major urinary protein 2 isoform 1 precursor

See identical proteins and their annotated locations for NP_001039015.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AL772327

Consensus CDS

CCDS18230.1

UniProtKB/TrEMBL

A2AKN9, Q9CXU6

Related

ENSMUSP00000126948.3, ENSMUST00000107490.5

Conserved Domains (1) summary

pfam00061
Location:34 → 170

Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
NM_001286096.1 → NP_001273025.1 major urinary protein 2 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate exon in the 3' coding region and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AL772327

Conserved Domains (1) summary

pfam00061
Location:14 → 109

Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
NM_008647.4 → NP_032673.3 major urinary protein 2 isoform 1 precursor

See identical proteins and their annotated locations for NP_032673.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AL772327

Consensus CDS

CCDS18230.1

UniProtKB/TrEMBL

A2AKN9, Q9CXU6

Related

ENSMUSP00000074264.3, ENSMUST00000074700.9

Conserved Domains (1) summary

pfam00061
Location:34 → 170

Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

60135913..60139977 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006537651.3 → XP_006537714.1 major urinary protein 2 isoform X1

Conserved Domains (1) summary

cd19428
Location:23 → 172

lipocalin_MUP-like; major urinary proteins (MUPs) and similar proteins