Slc2a6 solute carrier family 2 (facilitated glucose transporter), member 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc2a6provided by MGI
Official Full Name: solute carrier family 2 (facilitated glucose transporter), member 6provided by MGI
Primary source: MGI:MGI:2443286
See related: Ensembl:ENSMUSG00000036067 AllianceGenome:MGI:2443286
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Glut6; Glut9; GLUT-6; A330096C23; F630103L12Rik
Summary: Predicted to enable transmembrane transporter activity. Involved in regulation of glycolytic process. Predicted to be located in lysosomal membrane. Predicted to be active in membrane. Orthologous to human SLC2A6 (solute carrier family 2 member 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in cerebellum adult (RPKM 12.1), spleen adult (RPKM 11.0) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 19.18 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (26911375..26918011, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (27021363..27028000, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Investigating the Expression and Function of the Glucose Transporter GLUT6 in Obesity.
Title: Investigating the Expression and Function of the Glucose Transporter GLUT6 in Obesity.
Study provides evidence that GLUT6 is a lysosomal transporter that is regulated by inflammatory stimuli and modulates inflammatory responses by affecting the metabolic shift in macrophages.
Title: GLUT6 is a lysosomal transporter that is regulated by inflammatory stimuli and modulates glycolysis in macrophages.
these data show that GLUT6 is not a major regulator of whole body metabolic physiology
Title: Knockout of glucose transporter GLUT6 has minimal effects on whole body metabolic physiology in mice.
In liver-specific Glut9 knockout mice, inosine-induced hyperuricemia was not associated with hypertension despite partial renal deficiency.
Title: No development of hypertension in the hyperuricemic liver-Glut9 knockout mouse.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (1)

General gene information

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Markers

Slc2a6 (e-PCR), detects polymorphism
- UniSTS:547076

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
NOT enables D-glucose transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
NOT involved_in D-glucose transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of glycolytic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of glycolytic process	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: solute carrier family 2, facilitated glucose transporter member 6

Names: glucose transporter type 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001177627.1 → NP_001171098.1 solute carrier family 2, facilitated glucose transporter member 6 isoform 2

See identical proteins and their annotated locations for NP_001171098.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon in the 3' coding region compared to variant 1. The resulting isoform (2) is shorter but has the same N- and C-termini compared to isoform 1.

Source sequence(s)

BC058210, BC141168, BY202464

Consensus CDS

CCDS50544.1

UniProtKB/TrEMBL

A2AR26

Related

ENSMUSP00000099954.5, ENSMUST00000102890.11

Conserved Domains (2) summary

cd06174
Location:41 → 415

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam00083
Location:40 → 434

Sugar_tr; Sugar (and other) transporter
NM_172659.2 → NP_766247.2 solute carrier family 2, facilitated glucose transporter member 6 isoform 1

See identical proteins and their annotated locations for NP_766247.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK150104, BY202464

Consensus CDS

CCDS15822.1

UniProtKB/Swiss-Prot

A2AR26, Q3TLU5, Q3UDF0, Q8BTN2

Related

ENSMUSP00000049103.6, ENSMUST00000045702.6

Conserved Domains (1) summary

cl28910
Location:38 → 483

MFS; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

26911375..26918011 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006497917.5 → XP_006497980.1 solute carrier family 2, facilitated glucose transporter member 6 isoform X1

Conserved Domains (1) summary

cl28910
Location:1 → 385

MFS; Major Facilitator Superfamily