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    Plin4 perilipin 4 [ Mus musculus (house mouse) ]

    Gene ID: 57435, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Plin4provided by MGI
    Official Full Name
    perilipin 4provided by MGI
    Primary source
    MGI:MGI:1929709
    See related
    Ensembl:ENSMUSG00000002831 AllianceGenome:MGI:1929709
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    S3-12; mKIAA1881
    Summary
    Located in plasma membrane. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; immune system; and nervous system. Orthologous to human PLIN4 (perilipin 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in subcutaneous fat pad adult (RPKM 471.2), genital fat pad adult (RPKM 371.8) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Plin4 in Genome Data Viewer
    Location:
    17 29.16 cM; 17 D
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (56407587..56416947, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (56100587..56109948, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene chromatin assembly factor 1, subunit A Neighboring gene UBX domain protein 6 Neighboring gene STARR-positive B cell enhancer ABC_E100 Neighboring gene HDGF like 2 Neighboring gene nuclear encoded tRNA glutamic acid 4 (anticodon CTC) Neighboring gene perilipin 5 Neighboring gene leucine-rich alpha-2-glycoprotein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Plin4 exacerbates cadmium-decreased testosterone level via inducing ferroptosis in testicular Leydig cells. Zhang XD, et al. Redox Biol, 2024 Oct. PMID 39173539, Free PMC Article
    2. Perilipin 4 Protein: an Impending Target for Amyotrophic Lateral Sclerosis. Zhu L, et al. Mol Neurobiol, 2021 Apr. PMID 33242187
    3. Senp7 deficiency impairs lipid droplets maturation in white adipose tissues via Plin4 deSUMOylation. Pei J, et al. J Biol Chem, 2024 Jun. PMID 38677512, Free PMC Article
    4. Adipocyte protein S3-12 coats nascent lipid droplets. Wolins NE, et al. J Biol Chem, 2003 Sep 26. PMID 12840023
    5. Cloning of cell-specific secreted and surface proteins by subtractive antibody screening. Scherer PE, et al. Nat Biotechnol, 1998 Jun. PMID 9624692

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Plin4 exacerbates cadmium-decreased testosterone level via inducing ferroptosis in testicular Leydig cells.
      Title: Plin4 exacerbates cadmium-decreased testosterone level via inducing ferroptosis in testicular Leydig cells.
    2. Senp7 deficiency impairs lipid droplets maturation in white adipose tissues via Plin4 deSUMOylation.
      Title: Senp7 deficiency impairs lipid droplets maturation in white adipose tissues via Plin4 deSUMOylation.
    3. Perilipin 4 Protein: an Impending Target for Amyotrophic Lateral Sclerosis.
      Title: Perilipin 4 Protein: an Impending Target for Amyotrophic Lateral Sclerosis.
    4. Loss of Plin4 has no effect on body weight or composition or on adipose mass or development. Triacylglycerol (TAG) content in the heart is markedly reduced. The heart of Plin4(-/-) mice displays reduced Plin5 mRNA and protein levels.
      Title: Inactivation of Plin4 downregulates Plin5 and reduces cardiac lipid accumulation in mice.
    5. Direct regulation of perilipin and S3-12 by PPAR-gamma may to be important mediator of prolonged treatment with PPAR-gamma activators: insulin sensitization, fatty acid trapping in adipose tissue, reduced basal adipose lipolysis, and weight gain.
      Title: Adipose tissue expression of the lipid droplet-associating proteins S3-12 and perilipin is controlled by peroxisome proliferator-activated receptor-gamma.
    6. Adipocyte protein S3-12 coats nascent lipid droplets.
      Title: Adipocyte protein S3-12 coats nascent lipid droplets.
    7. the non-lipid droplet pools of S3-12, adipophilin, and TIP47 constitute a ready reservoir of coat proteins to permit rapid packaging of newly synthesized triacylglycerol and to maximize energy storage during nutrient excess
      Title: S3-12, Adipophilin, and TIP47 package lipid in adipocytes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    perilipin-4
    Names
    adipocyte protein S3-12
    plasma membrane associated protein, S3-12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001372234.1 → NP_001359163.1  perilipin-4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      CT009719
      Consensus CDS
      CCDS89124.1
      UniProtKB/TrEMBL
      A0A571BEC9
      Related
      ENSMUSP00000158677.2, ENSMUST00000238734.2
      Conserved Domains (2) summary
      cl28536
      Location:782 → 1316
      COG5412; Phage-related protein [Mobilome: prophages, transposons]
      pfam03036
      Location:1351 → 1582
      Perilipin; Perilipin family

    2. NM_001410163.1 → NP_001397092.1  perilipin-4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      CT009719

    3. NM_001410164.1 → NP_001397093.1  perilipin-4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      CT009719

    4. NM_001410165.1 → NP_001397094.1  perilipin-4 isoform 5

      Status: VALIDATED

      Source sequence(s)
      CT009719

    5. NM_001410166.1 → NP_001397095.1  perilipin-4 isoform 6

      Status: VALIDATED

      Source sequence(s)
      CT009719

    6. NM_001410167.1 → NP_001397096.1  perilipin-4 isoform 7

      Status: VALIDATED

      Source sequence(s)
      CT009719

    7. NM_001410168.1 → NP_001397097.1  perilipin-4 isoform 8

      Status: VALIDATED

      Source sequence(s)
      CT009719

    8. NM_001410172.1 → NP_001397101.1  perilipin-4 isoform 9

      Status: VALIDATED

      Source sequence(s)
      CT009719

    9. NM_001410173.1 → NP_001397102.1  perilipin-4 isoform 11

      Status: VALIDATED

      Source sequence(s)
      CT009719

    10. NM_001410174.1 → NP_001397103.1  perilipin-4 isoform 11

      Status: VALIDATED

      Source sequence(s)
      CT009719

    11. NM_001410175.1 → NP_001397104.1  perilipin-4 isoform 10

      Status: VALIDATED

      Source sequence(s)
      CT009719

    12. NM_020568.4 → NP_065593.2  perilipin-4 isoform 2

      See identical proteins and their annotated locations for NP_065593.2

      Status: VALIDATED

      Source sequence(s)
      CT009719
      Consensus CDS
      CCDS79565.1
      UniProtKB/Swiss-Prot
      E9QN72, O88492, Q69Z80, Q8BNV5
      Related
      ENSMUSP00000139859.2, ENSMUST00000190703.7
      Conserved Domains (2) summary
      cl28536
      Location:584 → 1118
      COG5412; Phage-related protein [Mobilome: prophages, transposons]
      pfam03036
      Location:1153 → 1384
      Perilipin; Perilipin family

    RNA

    1. NR_176959.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CT009719

    2. NR_176960.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CT009719

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      56407587..56416947 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246549.4 → XP_011244851.1  perilipin-4 isoform X5

      See identical proteins and their annotated locations for XP_011244851.1

      Conserved Domains (2) summary
      cl28536
      Location:693 → 1227
      COG5412; Phage-related protein [Mobilome: prophages, transposons]
      pfam03036
      Location:1262 → 1519
      Perilipin; Perilipin family

    2. XM_036160710.1 → XP_036016603.1  perilipin-4 isoform X9

      Conserved Domains (2) summary
      cl28536
      Location:782 → 1316
      COG5412; Phage-related protein [Mobilome: prophages, transposons]
      pfam03036
      Location:1351 → 1466
      Perilipin; Perilipin family

    3. XM_011246548.4 → XP_011244850.1  perilipin-4 isoform X4

      Conserved Domains (2) summary
      cl28536
      Location:118 → 466
      COG5412; Phage-related protein [Mobilome: prophages, transposons]
      pfam03036
      Location:1274 → 1531
      Perilipin; Perilipin family

    4. XM_017317591.3 → XP_017173080.1  perilipin-4 isoform X8

      Conserved Domains (2) summary
      cl28536
      Location:804 → 1338
      COG5412; Phage-related protein [Mobilome: prophages, transposons]
      pfam03036
      Location:1373 → 1485
      Perilipin; Perilipin family

    5. XM_011246551.4 → XP_011244853.1  perilipin-4 isoform X7

      Conserved Domains (2) summary
      cl28536
      Location:804 → 1338
      COG5412; Phage-related protein [Mobilome: prophages, transposons]
      pfam03036
      Location:1373 → 1490
      Perilipin; Perilipin family

    6. XM_011246550.3 → XP_011244852.1  perilipin-4 isoform X5

      See identical proteins and their annotated locations for XP_011244852.1

      Conserved Domains (2) summary
      cl28536
      Location:693 → 1227
      COG5412; Phage-related protein [Mobilome: prophages, transposons]
      pfam03036
      Location:1262 → 1519
      Perilipin; Perilipin family

    RNA

    1. XR_004939565.1 RNA Sequence

    2. XR_004939564.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88492.2 GenPept UniProtKB/Swiss-Prot:O88492

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