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    Etnppl ethanolamine phosphate phospholyase [ Mus musculus (house mouse) ]

    Gene ID: 71760, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Etnpplprovided by MGI
    Official Full Name
    ethanolamine phosphate phospholyaseprovided by MGI
    Primary source
    MGI:MGI:1919010
    See related
    Ensembl:ENSMUSG00000019232 AllianceGenome:MGI:1919010
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Agxt2l1; 1300019H02Rik
    Summary
    Predicted to enable ethanolamine-phosphate phospho-lyase activity. Acts upstream of or within several processes, including cellular response to glucocorticoid stimulus; ceramide phosphoethanolamine catabolic process; and phospholipid transfer to membrane. Predicted to be located in mitochondrion. Orthologous to human ETNPPL (ethanolamine-phosphate phospho-lyase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver adult (RPKM 16.0), liver E18 (RPKM 8.2) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Etnppl in Genome Data Viewer
    Location:
    3 G3; 3 60.47 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (130411097..130429399)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (130617448..130635750)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene makorin, ring finger protein, 1 pseudogene Neighboring gene collagen, type XXV, alpha 1 Neighboring gene STARR-seq mESC enhancer starr_08983 Neighboring gene predicted gene, 22682 Neighboring gene STARR-seq mESC enhancer starr_08984 Neighboring gene STARR-seq mESC enhancer starr_08985 Neighboring gene predicted gene, 36322 Neighboring gene predicted gene, 36373 Neighboring gene STARR-positive B cell enhancer ABC_E4590 Neighboring gene STARR-positive B cell enhancer ABC_E4591 Neighboring gene oligosaccharyltransferase complex subunit (non-catalytic)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Utilization of ethanolamine phosphate phospholyase as a unique astrocytic marker. Tsujioka H, et al. Front Cell Neurosci, 2023. PMID 36794261, Free PMC Article
    2. The role of ethanolamine phosphate phospholyase in regulation of astrocyte lipid homeostasis. White CJ, et al. J Biol Chem, 2021 Jul. PMID 34048714, Free PMC Article
    3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The role of ethanolamine phosphate phospholyase in regulation of astrocyte lipid homeostasis.
      Title: The role of ethanolamine phosphate phospholyase in regulation of astrocyte lipid homeostasis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (7)  1 citation
    • Targeted (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ethanolamine-phosphate phospho-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ethanolamine-phosphate phospho-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ethanolamine-phosphate phospho-lyase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within cellular response to glucocorticoid stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ceramide phosphoethanolamine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phospholipid transfer to membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to food IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ethanolamine-phosphate phospho-lyase
    Names
    alanine--glyoxylate aminotransferase 2-like 1
    NP_001157059.1
    NP_082183.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163587.1 → NP_001157059.1  ethanolamine-phosphate phospho-lyase

      See identical proteins and their annotated locations for NP_001157059.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK049937, BC058592
      Consensus CDS
      CCDS38638.1
      UniProtKB/Swiss-Prot
      Q811K4, Q8BWU8, Q9DBB3
      UniProtKB/TrEMBL
      E9PYH3
      Related
      ENSMUSP00000131294.2, ENSMUST00000166187.8
      Conserved Domains (2) summary
      cd00610
      Location:26 → 433
      OAT_like; Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase, ...
      COG0160
      Location:11 → 437
      GabT; 4-aminobutyrate aminotransferase or related aminotransferase [Amino acid transport and metabolism]

    2. NM_027907.3 → NP_082183.2  ethanolamine-phosphate phospho-lyase

      See identical proteins and their annotated locations for NP_082183.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK005060, BC058592
      Consensus CDS
      CCDS38638.1
      UniProtKB/Swiss-Prot
      Q811K4, Q8BWU8, Q9DBB3
      UniProtKB/TrEMBL
      E9PYH3
      Related
      ENSMUSP00000072121.7, ENSMUST00000072271.13
      Conserved Domains (2) summary
      cd00610
      Location:26 → 433
      OAT_like; Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase, ...
      COG0160
      Location:11 → 437
      GabT; 4-aminobutyrate aminotransferase or related aminotransferase [Amino acid transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      130411097..130429399
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BWU8.1 GenPept UniProtKB/Swiss-Prot:Q8BWU8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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