Dpp9 dipeptidylpeptidase 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dpp9provided by MGI
Official Full Name: dipeptidylpeptidase 9provided by MGI
Primary source: MGI:MGI:2443967
See related: Ensembl:ENSMUSG00000001229 AllianceGenome:MGI:2443967
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DPRP2; DPP IX; A330078I11; 6430584G11Rik
Summary: Predicted to enable dipeptidyl-peptidase activity and identical protein binding activity. Predicted to be involved in negative regulation of programmed cell death and proteolysis. Predicted to act upstream of with a negative effect on pyroptotic inflammatory response. Predicted to be located in cell leading edge and microtubule. Predicted to be active in cytosol. Is expressed in several structures, including forelimb bud; gut; male reproductive gland or organ; myotome; and nervous system. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human DPP9 (dipeptidyl peptidase 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in lung adult (RPKM 24.7), thymus adult (RPKM 22.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 D; 17 29.2 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (56493674..56525927, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (56186674..56218889, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dipeptidyl-peptidase 9 regulates the dynamics of tumorigenesis and metastasis in breast cancer.
Title: Dipeptidyl-peptidase 9 regulates the dynamics of tumorigenesis and metastasis in breast cancer.
DPP9 deficiency: An inflammasomopathy that can be rescued by lowering NLRP1/IL-1 signaling.
Title: DPP9 deficiency: An inflammasomopathy that can be rescued by lowering NLRP1/IL-1 signaling.
Immune regeneration in irradiated mice is not impaired by the absence of DPP9 enzymatic activity.
Title: Immune regeneration in irradiated mice is not impaired by the absence of DPP9 enzymatic activity.
The effect of CD26-deficiency on dipeptidyl peptidase 8 and 9 expression profiles in a mouse model of Crohn's disease.
Title: The effect of CD26-deficiency on dipeptidyl peptidase 8 and 9 expression profiles in a mouse model of Crohn's disease.
Dipeptidyl peptidase 9 (DPP9) knock-in mice (DPP9(ki/ki) mice)express a catalytically inactive S729A mutant of DPP9 enzyme. DPP9(ki/ki) mice show reduced number of lymphoid and myeloid cells in fetal liver and postnatal blood but their hematopoietic cells are fully functional and able to reconstitute lymphoid and myeloid lineages even in competitive mixed chimeras.
Title: DPP9 enzymatic activity in hematopoietic cells is dispensable for mouse hematopoiesis.
lack of DPP9 activity in mice leads to impaired tongue development, suckling defect and subsequent neonatal lethality.
Title: DPP9 enzyme activity controls survival of mouse migratory tongue muscle progenitors and its absence leads to neonatal lethality due to suckling defect.
Changes induced by DPP9 gene silencing in macrophages suggest possible role of DPP9 in regulation of proliferation and activation status, as well as in peptide processing within endosomal/vesicular compartment.
Title: Expression, subcellular localisation, and possible roles of dipeptidyl peptidase 9 (DPP9) in murine macrophages.
DPP9 enzyme activity regulates metabolic pathways in neonatal liver and gut.
Title: Dipeptidyl peptidase 9 enzymatic activity influences the expression of neonatal metabolic genes.
Blocking the expression or activities of DPP8 and DPP9 attenuates PPARgamma2 induction during preadipocyte differentiation.
Title: Inhibition of dipeptidyl peptidase 8/9 impairs preadipocyte differentiation.
Identification of novel dipeptidyl peptidase 9 substrates: discovering dipeptide Val-Ala as a consensus site for DPP9 cleavage
Title: Identification of novel dipeptidyl peptidase 9 substrates by two-dimensional differential in-gel electrophoresis.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (1)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables aminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables dipeptidyl-peptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dipeptidyl-peptidase activity	ISO Inferred from Sequence Orthology more info
enables dipeptidyl-peptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables serine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of programmed cell death	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of programmed cell death	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_negative_effect pyroptotic inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_negative_effect pyroptotic inflammatory response	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell leading edge	IEA Inferred from Electronic Annotation more info
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dipeptidyl peptidase 9

Names: DP9; DPLP9; dipeptidyl peptidase IX; dipeptidyl peptidase-like protein 9

NP_001347213.1

EC 3.4.14.5

NP_766212.2

EC 3.4.14.5

XP_006524218.1

EC 3.4.14.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360284.1 → NP_001347213.1 dipeptidyl peptidase 9 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC026385

Conserved Domains (2) summary

pfam00326
Location:720 → 921

Peptidase_S9; Prolyl oligopeptidase family

cl27623
Location:204 → 628

DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
NM_172624.3 → NP_766212.2 dipeptidyl peptidase 9 isoform 2

See identical proteins and their annotated locations for NP_766212.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AK050021, AK050023, AK078301

Consensus CDS

CCDS37663.1

UniProtKB/Swiss-Prot

Q6KAM9, Q8BVG4, Q8BWT9

Related

ENSMUSP00000046604.5, ENSMUST00000038794.6

Conserved Domains (2) summary

pfam00326
Location:661 → 862

Peptidase_S9; Prolyl oligopeptidase family

pfam00930
Location:145 → 568

DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

56493674..56525927 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006524155.5 → XP_006524218.1 dipeptidyl peptidase 9 isoform X1

See identical proteins and their annotated locations for XP_006524218.1

UniProtKB/Swiss-Prot

Q6KAM9, Q8BVG4, Q8BWT9

Conserved Domains (2) summary

pfam00326
Location:661 → 862

Peptidase_S9; Prolyl oligopeptidase family

pfam00930
Location:145 → 568

DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region