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    Ablim1 actin-binding LIM protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 226251, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ablim1provided by MGI
    Official Full Name
    actin-binding LIM protein 1provided by MGI
    Primary source
    MGI:MGI:1194500
    See related
    Ensembl:ENSMUSG00000025085 AllianceGenome:MGI:1194500
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Limab1; mKIAA0059; 2210411C18Rik; 2610209L21Rik; 4833406P10Rik; 9330196J19Rik
    Summary
    Enables actin binding activity. Acts upstream of or within axon guidance and positive regulation of transcription by RNA polymerase II. Located in actin cytoskeleton. Is active in postsynaptic density. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; lateral plate mesoderm; and node. Orthologous to human ABLIM1 (actin binding LIM protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 23.3), heart adult (RPKM 17.9) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ablim1 in Genome Data Viewer
    Location:
    19 D2; 19 52.09 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (57021165..57303776, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (57032733..57315344, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_46534 Neighboring gene von Willebrand factor A domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_46535 Neighboring gene actin filament associated protein 1-like 2 Neighboring gene predicted gene, 38597 Neighboring gene STARR-positive B cell enhancer ABC_E3255 Neighboring gene STARR-seq mESC enhancer starr_46541 Neighboring gene STARR-positive B cell enhancer ABC_E1531 Neighboring gene STARR-positive B cell enhancer ABC_E4293 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:57205992-57206175 Neighboring gene STARR-seq mESC enhancer starr_46543 Neighboring gene STARR-seq mESC enhancer starr_46545 Neighboring gene STARR-seq mESC enhancer starr_46546 Neighboring gene STARR-positive B cell enhancer ABC_E11042 Neighboring gene STARR-seq mESC enhancer starr_46548 Neighboring gene STARR-positive B cell enhancer ABC_E7676 Neighboring gene RIKEN cDNA 4930449E18 gene Neighboring gene RIKEN cDNA B230217O12 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:57430022-57430395 Neighboring gene predicted gene, 50270 Neighboring gene FHF complex subunit HOOK interacting protein 2A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Normal retinal development and retinofugal projections in mice lacking the retina-specific variant of actin-binding LIM domain protein. Lu C, et al. Neuroscience, 2003. PMID 12849746
    2. Actin-binding LIM protein 1 regulates receptor activator of NF-κB ligand-mediated osteoclast differentiation and motility. Jin SH, et al. BMB Rep, 2018 Jul. PMID 29921413, Free PMC Article
    3. Actin binding LIM 1 (abLIM1) negatively controls osteoclastogenesis by regulating cell migration and fusion. Narahara H, et al. J Cell Physiol, 2018 Jan. PMID 29904924
    4. Molecular characterization of abLIM, a novel actin-binding and double zinc finger protein. Roof DJ, et al. J Cell Biol, 1997 Aug 11. PMID 9245787, Free PMC Article
    5. Tectorin-beta (Tectb) maps to mouse chromosome 19. Kim HJ, et al. Genomics, 1998 Nov 1. PMID 9799617

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. abLIM1 regulated the localization of tubulin, migration, and fusion in osteoclasts. Thus, these results indicate that abLIM1 negatively controls osteoclast differentiation by regulating cell migration and fusion mediated via actin formation.
      Title: Actin binding LIM 1 (abLIM1) negatively controls osteoclastogenesis by regulating cell migration and fusion.
    2. ABLIM1 is associated with the regulation of preosteoclast motility via the PI3K/Akt/Rac1 pathway during RANKL-mediated osteoclastogenesis.
      Title: Actin-binding LIM protein 1 regulates receptor activator of NF-κB ligand-mediated osteoclast differentiation and motility.
    3. these results make Ablim1 a candidate for controlling aspects of left-right identity and patterning.
      Title: Analysis of the asymmetrically expressed Ablim1 locus reveals existence of a lateral plate Nodal-independent left sided signal and an early, left-right independent role for nodal flow.
    4. AbLIM-L mutant mice exhibit no apparent morphological or functional defects in photoreceptors and inner retinal neurons. Retinofugal projections and synaptic maturation also appear normal; abLIM-M is likely the isoform related to axon guidance.
      Title: Normal retinal development and retinofugal projections in mice lacking the retina-specific variant of actin-binding LIM domain protein.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within axon guidance IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lamellipodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    is_active_in stress fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    actin-binding LIM protein 1
    Names
    actin-binding LIM protein family member 1
    actin-binding double zinc finger protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001103177.3 → NP_001096647.1  actin-binding LIM protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001096647.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and lacks three alternate in-frame exons inthe 3' coding region, compared to variant 1. It initiates translation at an alternate start codon. The encoded isoform (2, also known as abLIM-m) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC102655, AC161518, AF404775, AW060969, BE994737
      Consensus CDS
      CCDS50479.1
      UniProtKB/TrEMBL
      Q3UP03
      Related
      ENSMUSP00000107172.2, ENSMUST00000111546.8
      Conserved Domains (6) summary
      smart00153
      Location:666 → 701
      VHP; Villin headpiece domain
      cd09327
      Location:23 → 74
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:79 → 134
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:150 → 201
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:209 → 264
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:274 → 665
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    2. NM_001103178.3 → NP_001096648.1  actin-binding LIM protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks multiple 5' coding exons, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3, also known as abLIM-s) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AC102655, AC161518, AF404776, AK008893, BE994737, BY268130
      Consensus CDS
      CCDS50478.1
      UniProtKB/TrEMBL
      E9Q030, E9Q9D2
      Related
      ENSMUSP00000127818.2, ENSMUST00000104902.9
      Conserved Domains (3) summary
      smart00153
      Location:510 → 545
      VHP; Villin headpiece domain
      pfam16182
      Location:78 → 509
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
      cl02475
      Location:1 → 24
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    3. NM_001290813.2 → NP_001277742.1  actin-binding LIM protein 1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks four alternate in-frame exons in the 3' coding region, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AC161518, AF404774, BE994737
      UniProtKB/TrEMBL
      B9EIV0
      Related
      ENSMUSP00000107180.2, ENSMUST00000111555.8
      Conserved Domains (6) summary
      smart00153
      Location:695 → 730
      VHP; Villin headpiece domain
      cd09327
      Location:99 → 150
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:155 → 210
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:226 → 277
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:285 → 340
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:349 → 680
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    4. NM_001290815.2 → NP_001277744.1  actin-binding LIM protein 1 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and lacks four alternate in-frame exons in the 3' coding region, compared to variant 1. It initiates translation at an alternate start codon. The encoded isoform (5) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC102655, AC161518, AF404775, AW060969, BE994737
      Consensus CDS
      CCDS70964.1
      UniProtKB/TrEMBL
      E9Q9C4
      Related
      ENSMUSP00000096897.3, ENSMUST00000099294.9
      Conserved Domains (6) summary
      smart00153
      Location:619 → 654
      VHP; Villin headpiece domain
      cd09327
      Location:23 → 74
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:79 → 134
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:150 → 201
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:209 → 264
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:274 → 618
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    5. NM_001290816.2 → NP_001277745.1  actin-binding LIM protein 1 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and lacks four alternate in-frame exons and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It initiates translation at an alternate start codon. The encoded isoform (6) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC102655, AC161518, AK143907, BE994737
      Consensus CDS
      CCDS70963.1
      UniProtKB/TrEMBL
      E9Q9C7, Q3UP03
      Related
      ENSMUSP00000107169.2, ENSMUST00000111544.8
      Conserved Domains (6) summary
      smart00153
      Location:633 → 668
      VHP; Villin headpiece domain
      cd09327
      Location:23 → 74
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:79 → 134
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:150 → 201
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:209 → 264
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:274 → 632
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    6. NM_001347459.1 → NP_001334388.1  actin-binding LIM protein 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC102655, AC161518
      Consensus CDS
      CCDS84456.1
      UniProtKB/TrEMBL
      E9Q9D1, E9Q9Q7
      Related
      ENSMUSP00000107154.2, ENSMUST00000111529.8

    7. NM_001362445.1 → NP_001349374.1  actin-binding LIM protein 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC102655, AC131756, AC161518
      UniProtKB/TrEMBL
      E9Q9C4
      Conserved Domains (6) summary
      smart00153
      Location:618 → 653
      VHP; Villin headpiece domain
      cd09327
      Location:22 → 73
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:78 → 133
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:149 → 200
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:208 → 263
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:273 → 617
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    8. NM_001362446.1 → NP_001349375.1  actin-binding LIM protein 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC102655, AC131756, AC161518
      UniProtKB/TrEMBL
      E9Q9C4
      Conserved Domains (5) summary
      smart00153
      Location:543 → 578
      VHP; Villin headpiece domain
      cd09328
      Location:3 → 58
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:74 → 125
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:133 → 188
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:198 → 542
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    9. NM_178688.4 → NP_848803.3  actin-binding LIM protein 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1, also known as abLIM-l).
      Source sequence(s)
      AC102655, AC161518, AF404774, BE994737
      Consensus CDS
      CCDS38027.1
      UniProtKB/Swiss-Prot
      Q80U86, Q8BIR9, Q8K4G3, Q8K4G4, Q8K4G5
      UniProtKB/TrEMBL
      E9QK41
      Related
      ENSMUSP00000078336.6, ENSMUST00000079360.12
      Conserved Domains (6) summary
      smart00153
      Location:826 → 861
      VHP; Villin headpiece domain
      cd09327
      Location:99 → 150
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:155 → 210
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:226 → 277
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:285 → 340
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:394 → 825
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      57021165..57303776 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250917.1 → XP_030106777.1  actin-binding LIM protein 1 isoform X22

      UniProtKB/TrEMBL
      Q3UP03
      Conserved Domains (6) summary
      smart00153
      Location:632 → 667
      VHP; Villin headpiece domain
      cd09327
      Location:22 → 73
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:78 → 133
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:149 → 200
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:208 → 263
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:272 → 630
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    2. XM_030250916.1 → XP_030106776.1  actin-binding LIM protein 1 isoform X18

      UniProtKB/TrEMBL
      Q3UP03
      Conserved Domains (6) summary
      smart00153
      Location:667 → 702
      VHP; Villin headpiece domain
      cd09327
      Location:22 → 73
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:78 → 133
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:149 → 200
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:208 → 263
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:272 → 665
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    3. XM_030250913.1 → XP_030106773.1  actin-binding LIM protein 1 isoform X9

      UniProtKB/TrEMBL
      Q3UP03
      Conserved Domains (6) summary
      smart00153
      Location:707 → 742
      VHP; Villin headpiece domain
      cd09327
      Location:22 → 73
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:78 → 133
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:149 → 200
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:208 → 263
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:272 → 705
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    4. XM_017318175.3 → XP_017173664.1  actin-binding LIM protein 1 isoform X5

      UniProtKB/Swiss-Prot
      Q80U86, Q8BIR9, Q8K4G3, Q8K4G4, Q8K4G5
      Conserved Domains (6) summary
      smart00153
      Location:735 → 770
      VHP; Villin headpiece domain
      cd09327
      Location:22 → 73
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:78 → 133
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:149 → 200
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:208 → 263
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:300 → 733
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    5. XM_006527028.5 → XP_006527091.1  actin-binding LIM protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q80U86, Q8BIR9, Q8K4G3, Q8K4G4, Q8K4G5
      Conserved Domains (6) summary
      smart00153
      Location:749 → 784
      VHP; Villin headpiece domain
      cd09327
      Location:36 → 87
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:92 → 147
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:163 → 214
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:222 → 277
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:314 → 747
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    6. XM_017318172.3 → XP_017173661.1  actin-binding LIM protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q80U86, Q8BIR9, Q8K4G3, Q8K4G4, Q8K4G5
      Conserved Domains (6) summary
      smart00153
      Location:747 → 782
      VHP; Villin headpiece domain
      cd09327
      Location:36 → 87
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:92 → 147
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:163 → 214
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:222 → 277
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:314 → 745
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    7. XM_006527036.5 → XP_006527099.1  actin-binding LIM protein 1 isoform X11

      UniProtKB/TrEMBL
      E9Q9C4
      Conserved Domains (6) summary
      smart00153
      Location:700 → 735
      VHP; Villin headpiece domain
      cd09327
      Location:36 → 87
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:92 → 147
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:163 → 214
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:222 → 277
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:314 → 698
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    8. XM_006527034.5 → XP_006527097.1  actin-binding LIM protein 1 isoform X7

      UniProtKB/TrEMBL
      E9Q9C1, E9Q9C4
      Related
      ENSMUSP00000107183.2, ENSMUST00000111558.8
      Conserved Domains (6) summary
      smart00153
      Location:709 → 744
      VHP; Villin headpiece domain
      cd09327
      Location:36 → 87
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:92 → 147
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:163 → 214
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:222 → 277
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:314 → 707
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    9. XM_006527035.5 → XP_006527098.1  actin-binding LIM protein 1 isoform X10

      UniProtKB/TrEMBL
      E9Q9C4
      Conserved Domains (6) summary
      smart00153
      Location:707 → 742
      VHP; Villin headpiece domain
      cd09327
      Location:36 → 87
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:92 → 147
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:163 → 214
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:222 → 277
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:314 → 705
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    10. XM_006527033.5 → XP_006527096.1  actin-binding LIM protein 1 isoform X6

      UniProtKB/TrEMBL
      Q3UP03
      Conserved Domains (6) summary
      smart00153
      Location:721 → 756
      VHP; Villin headpiece domain
      cd09327
      Location:36 → 87
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:92 → 147
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:163 → 214
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:222 → 277
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:286 → 719
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    11. XM_006527040.5 → XP_006527103.1  actin-binding LIM protein 1 isoform X19

      UniProtKB/TrEMBL
      E9Q9C4
      Conserved Domains (6) summary
      smart00153
      Location:660 → 695
      VHP; Villin headpiece domain
      cd09327
      Location:36 → 87
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:92 → 147
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:163 → 214
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:222 → 277
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:314 → 658
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    12. XM_017318177.3 → XP_017173666.1  actin-binding LIM protein 1 isoform X15

      UniProtKB/TrEMBL
      E9Q9C4
      Conserved Domains (6) summary
      smart00153
      Location:672 → 707
      VHP; Villin headpiece domain
      cd09327
      Location:36 → 87
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:92 → 147
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:163 → 214
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:222 → 277
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:286 → 670
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    13. XM_006527038.5 → XP_006527101.1  actin-binding LIM protein 1 isoform X14

      UniProtKB/TrEMBL
      Q3UP03
      Conserved Domains (6) summary
      smart00153
      Location:674 → 709
      VHP; Villin headpiece domain
      cd09327
      Location:36 → 87
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:92 → 147
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:163 → 214
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:222 → 277
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:314 → 672
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    14. XM_006527039.5 → XP_006527102.1  actin-binding LIM protein 1 isoform X16

      UniProtKB/TrEMBL
      Q3UP03
      Conserved Domains (6) summary
      smart00153
      Location:672 → 707
      VHP; Villin headpiece domain
      cd09327
      Location:36 → 87
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:92 → 147
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:163 → 214
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:222 → 277
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:314 → 670
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    15. XM_030250914.2 → XP_030106774.1  actin-binding LIM protein 1 isoform X12

      UniProtKB/TrEMBL
      Q3UP03
      Conserved Domains (6) summary
      smart00153
      Location:681 → 716
      VHP; Villin headpiece domain
      cd09327
      Location:36 → 87
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:92 → 147
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:163 → 214
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:222 → 277
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:286 → 679
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    16. XM_006527037.5 → XP_006527100.1  actin-binding LIM protein 1 isoform X13

      UniProtKB/TrEMBL
      E9Q9C0, Q3UP03
      Related
      ENSMUSP00000107184.2, ENSMUST00000111559.8
      Conserved Domains (6) summary
      smart00153
      Location:679 → 714
      VHP; Villin headpiece domain
      cd09327
      Location:36 → 87
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:92 → 147
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:163 → 214
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:222 → 277
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:286 → 677
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    17. XM_006527044.5 → XP_006527107.1  actin-binding LIM protein 1 isoform X24

      UniProtKB/TrEMBL
      E9Q9C4
      Conserved Domains (6) summary
      smart00153
      Location:625 → 660
      VHP; Villin headpiece domain
      cd09327
      Location:36 → 87
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:92 → 147
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:163 → 214
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:222 → 277
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:314 → 623
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    18. XM_017318179.3 → XP_017173668.1  actin-binding LIM protein 1 isoform X23

      UniProtKB/TrEMBL
      E9Q9C4
      Conserved Domains (6) summary
      smart00153
      Location:632 → 667
      VHP; Villin headpiece domain
      cd09327
      Location:36 → 87
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:92 → 147
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:163 → 214
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:222 → 277
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:286 → 630
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    19. XM_006527041.5 → XP_006527104.1  actin-binding LIM protein 1 isoform X20

      UniProtKB/TrEMBL
      Q3UP03
      Conserved Domains (6) summary
      smart00153
      Location:646 → 681
      VHP; Villin headpiece domain
      cd09327
      Location:36 → 87
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:92 → 147
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:163 → 214
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:222 → 277
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:286 → 644
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    20. XM_017318178.3 → XP_017173667.1  actin-binding LIM protein 1 isoform X21

      UniProtKB/TrEMBL
      Q3UP03
      Conserved Domains (6) summary
      smart00153
      Location:644 → 679
      VHP; Villin headpiece domain
      cd09327
      Location:36 → 87
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:92 → 147
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:163 → 214
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:222 → 277
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:286 → 642
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    21. XM_017318181.3 → XP_017173670.1  actin-binding LIM protein 1 isoform X25

      UniProtKB/TrEMBL
      Q3UP03
      Conserved Domains (6) summary
      smart00153
      Location:597 → 632
      VHP; Villin headpiece domain
      cd09327
      Location:36 → 87
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:92 → 147
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:163 → 214
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:222 → 277
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:286 → 595
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    22. XM_030250915.1 → XP_030106775.1  actin-binding LIM protein 1 isoform X17

      UniProtKB/TrEMBL
      Q3UP03
      Conserved Domains (6) summary
      smart00153
      Location:668 → 703
      VHP; Villin headpiece domain
      cd09327
      Location:23 → 74
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:79 → 134
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:150 → 201
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:209 → 264
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:273 → 666
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    23. XM_030250912.1 → XP_030106772.1  actin-binding LIM protein 1 isoform X8

      UniProtKB/TrEMBL
      Q3UP03
      Conserved Domains (6) summary
      smart00153
      Location:708 → 743
      VHP; Villin headpiece domain
      cd09327
      Location:23 → 74
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:79 → 134
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:150 → 201
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:209 → 264
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:273 → 706
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    24. XM_017318174.3 → XP_017173663.1  actin-binding LIM protein 1 isoform X4

      UniProtKB/Swiss-Prot
      Q80U86, Q8BIR9, Q8K4G3, Q8K4G4, Q8K4G5
      Conserved Domains (6) summary
      smart00153
      Location:736 → 771
      VHP; Villin headpiece domain
      cd09327
      Location:23 → 74
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:79 → 134
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:150 → 201
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:209 → 264
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:301 → 734
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    25. XM_017318173.3 → XP_017173662.1  actin-binding LIM protein 1 isoform X3

      UniProtKB/Swiss-Prot
      Q80U86, Q8BIR9, Q8K4G3, Q8K4G4, Q8K4G5
      Conserved Domains (6) summary
      smart00153
      Location:740 → 775
      VHP; Villin headpiece domain
      cd09327
      Location:27 → 78
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:83 → 138
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:154 → 205
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:213 → 268
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:305 → 738
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    26. XM_017318183.2 → XP_017173672.1  actin-binding LIM protein 1 isoform X26

      UniProtKB/TrEMBL
      E9Q9D2
      Conserved Domains (3) summary
      smart00153
      Location:496 → 531
      VHP; Villin headpiece domain
      cl02475
      Location:1 → 24
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam16182
      Location:61 → 494
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    27. XM_017318182.3 → XP_017173671.1  actin-binding LIM protein 1 isoform X26

      UniProtKB/TrEMBL
      E9Q9D2
      Conserved Domains (3) summary
      smart00153
      Location:496 → 531
      VHP; Villin headpiece domain
      cl02475
      Location:1 → 24
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam16182
      Location:61 → 494
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    28. XM_006527048.5 → XP_006527111.1  actin-binding LIM protein 1 isoform X27

      UniProtKB/TrEMBL
      E9Q9D2
      Conserved Domains (3) summary
      smart00153
      Location:468 → 503
      VHP; Villin headpiece domain
      cl02475
      Location:1 → 24
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam16182
      Location:33 → 466
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    29. XM_030250918.2 → XP_030106778.1  actin-binding LIM protein 1 isoform X28

      UniProtKB/TrEMBL
      E9Q9D2
      Conserved Domains (3) summary
      smart00153
      Location:428 → 463
      VHP; Villin headpiece domain
      cl02475
      Location:1 → 24
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam16182
      Location:33 → 426
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    30. XM_030250919.2 → XP_030106779.1  actin-binding LIM protein 1 isoform X30

      UniProtKB/TrEMBL
      E9Q9D2
      Conserved Domains (3) summary
      smart00153
      Location:379 → 414
      VHP; Villin headpiece domain
      cl02475
      Location:1 → 24
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam16182
      Location:33 → 377
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    31. XM_017318184.3 → XP_017173673.1  actin-binding LIM protein 1 isoform X29

      UniProtKB/TrEMBL
      E9Q9Q7
      Conserved Domains (3) summary
      smart00153
      Location:393 → 428
      VHP; Villin headpiece domain
      cl02475
      Location:1 → 24
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam16182
      Location:33 → 391
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    32. XM_017318186.3 → XP_017173675.1  actin-binding LIM protein 1 isoform X31

      UniProtKB/TrEMBL
      E9Q9D2
      Conserved Domains (3) summary
      smart00153
      Location:344 → 379
      VHP; Villin headpiece domain
      cl02475
      Location:1 → 24
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam16182
      Location:33 → 342
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K4G5.1 GenPept UniProtKB/Swiss-Prot:Q8K4G5

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