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    Cyp2c40 cytochrome P450, family 2, subfamily c, polypeptide 40 [ Mus musculus (house mouse) ]

    Gene ID: 13099, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cyp2c40provided by MGI
    Official Full Name
    cytochrome P450, family 2, subfamily c, polypeptide 40provided by MGI
    Primary source
    MGI:MGI:1306815
    See related
    Ensembl:ENSMUSG00000025004 AllianceGenome:MGI:1306815
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables arachidonate 14,15-epoxygenase activity. Predicted to be involved in epoxygenase P450 pathway and xenobiotic metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in embryo; liver; and metanephros. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver adult (RPKM 249.7) and liver E18 (RPKM 201.4) See more
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    Genomic context

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    See Cyp2c40 in Genome Data Viewer
    Location:
    19 C3; 19 34.24 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (39755517..39801258, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (39767073..39812814, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 67 Neighboring gene STARR-seq mESC enhancer starr_46115 Neighboring gene STARR-seq mESC enhancer starr_46116 Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 68 Neighboring gene STARR-seq mESC enhancer starr_46117 Neighboring gene STARR-seq mESC enhancer starr_46118 Neighboring gene STARR-seq mESC enhancer starr_46119 Neighboring gene STARR-seq mESC enhancer starr_46120 Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 69 Neighboring gene STARR-seq mESC enhancer starr_46121 Neighboring gene STARR-seq mESC enhancer starr_46122 Neighboring gene STARR-seq mESC enhancer starr_46123 Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 71, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CYP2C40, a unique arachidonic acid 16-hydroxylase, is the major CYP2C in murine intestinal tract. Tsao CC, et al. Mol Pharmacol, 2000 Aug. PMID 10908295
    2. Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid. Luo G, et al. Arch Biochem Biophys, 1998 Sep 1. PMID 9721182
    3. Emergence of complex rearrangements at translocation breakpoints in a transgenic mouse; implications for mechanisms involved in the formation of chromosome rearrangements. Kasai F, et al. Cytogenet Genome Res, 2007. PMID 18160786
    4. Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity. Wang S, et al. PLoS Genet, 2006 Feb. PMID 16462940, Free PMC Article
    5. Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic Cyp Gene Expression in the Adult Mouse Liver. Creasy KT, et al. Gene Expr, 2016. PMID 27197076, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables arachidonate 14,15-epoxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in arachidonate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in organic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in xenobiotic metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 2C40
    Names
    CYPIIC40
    cytochrome P450, 2c40
    NP_034134.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010004.3 → NP_034134.3  cytochrome P450 2C40 precursor

      Status: VALIDATED

      Source sequence(s)
      AC121935
      Consensus CDS
      CCDS29798.3
      UniProtKB/Swiss-Prot
      B2RTP3, P56657
      UniProtKB/TrEMBL
      Q8VCP4
      Related
      ENSMUSP00000125217.3, ENSMUST00000160476.9
      Conserved Domains (1) summary
      pfam00067
      Location:30 → 487
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      39755517..39801258 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P56657.2 GenPept UniProtKB/Swiss-Prot:P56657

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