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    CBR3-AS1 CBR3 antisense RNA 1 [ Homo sapiens (human) ]

    Gene ID: 100506428, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CBR3-AS1provided by HGNC
    Official Full Name
    CBR3 antisense RNA 1provided by HGNC
    Primary source
    HGNC:HGNC:43664
    See related
    Ensembl:ENSG00000236830 AllianceGenome:HGNC:43664
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PlncRNA1; PlncRNA-1
    Expression
    Ubiquitous expression in prostate (RPKM 4.6), salivary gland (RPKM 3.1) and 25 other tissues See more
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    Genomic context

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    See CBR3-AS1 in Genome Data Viewer
    Location:
    21q22.12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (36131767..36156308, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (34514794..34539161, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (37504065..37528606, complement)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18423 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18424 Neighboring gene CBR1 antisense RNA 1 Neighboring gene carbonyl reductase 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr21:37471927-37472788 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:37477035-37477536 Neighboring gene uncharacterized LOC105369306 Neighboring gene MPRA-validated peak4410 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18425 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18426 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:37485624-37486136 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18427 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:37506732-37507539 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:37507540-37508346 Neighboring gene MEMO1 pseudogene 1 Neighboring gene ribosomal protein S9 pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:37527648-37528315 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:37528316-37528982 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13281 Neighboring gene carbonyl reductase 3 Neighboring gene DOP1 leucine zipper like protein B Neighboring gene uncharacterized LOC124905016 Neighboring gene ribosomal protein L3 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. High expression of Plnc RNA-1 promotes the progression of colorectal cancer. Song B, et al. J BUON, 2019 Jan-Feb. PMID 30941957
    2. Upregulation of Long Non-Coding RNA PlncRNA-1 Promotes Metastasis and Induces Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma. Dong L, et al. Cell Physiol Biochem, 2016. PMID 26906068
    3. Upregulation of long non-coding RNA PlncRNA-1 promotes proliferation and induces epithelial-mesenchymal transition in prostate cancer. Jin Y, et al. Oncotarget, 2017 Apr 18. PMID 28212533, Free PMC Article
    4. Long Noncoding RNA PlncRNA-1 Promotes Colorectal Cancer Cell Progression by Regulating the PI3K/Akt Signaling Pathway. Song W, et al. Oncol Res, 2018 Mar 5. PMID 28835319, Free PMC Article
    5. LncRNA CBR3-AS1 predicts unfavorable prognosis and promotes tumorigenesis in osteosarcoma. Zhang Y, et al. Biomed Pharmacother, 2018 Jun. PMID 29554595

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncRNA-CBR3-AS1 promotes and enhances the malignancy of ulcerative colitis via targeting miRNA-145-5p/FN1.
      Title: LncRNA-CBR3-AS1 promotes and enhances the malignancy of ulcerative colitis via targeting miRNA-145-5p/FN1.
    2. LncRNA CBR3-AS1 predicts a poor prognosis and promotes cervical cancer progression through the miR-3163/LASP1 pathway.
      Title: LncRNA CBR3-AS1 predicts a poor prognosis and promotes cervical cancer progression through the miR-3163/LASP1 pathway.
    3. Long Non-coding RNA CBR3 Antisense RNA 1 is Downregulated in Colorectal Cancer and Inhibits miR-29a-Mediated Cell Migration and Invasion.
      Title: Long Non-coding RNA CBR3 Antisense RNA 1 is Downregulated in Colorectal Cancer and Inhibits miR-29a-Mediated Cell Migration and Invasion.
    4. Long Non-Coding RNAs Expression in Breast Cancer: CBR3-AS1 LncRNA as a Sensitive Biomarker.
      Title: Long Non-Coding RNAs Expression in Breast Cancer: CBR3-AS1 LncRNA as a Sensitive Biomarker.
    5. LncRNA CBR3-AS1 regulates of breast cancer drug sensitivity as a competing endogenous RNA through the JNK1/MEK4-mediated MAPK signal pathway.
      Title: LncRNA CBR3-AS1 regulates of breast cancer drug sensitivity as a competing endogenous RNA through the JNK1/MEK4-mediated MAPK signal pathway.
    6. LncRNA PlncRNA-1 accelerates the progression of prostate cancer by regulating PTEN/Akt axis.
      Title: LncRNA PlncRNA-1 accelerates the progression of prostate cancer by regulating PTEN/Akt axis.
    7. LncRNA PlncRNA-1 participates in rheumatoid arthritis by regulating transforming growth factor beta1.
      Title: LncRNA PlncRNA-1 participates in rheumatoid arthritis by regulating transforming growth factor β1.
    8. Long noncoding RNA CBR3 antisense RNA 1 promotes the aggressive phenotypes of nonsmallcell lung cancer by sponging microRNA5093p and competitively upregulating HDAC9 expression.
      Title: Long noncoding RNA CBR3 antisense RNA 1 promotes the aggressive phenotypes of non‑small‑cell lung cancer by sponging microRNA‑509‑3p and competitively upregulating HDAC9 expression.
    9. Hypomethylation of PlncRNA-1 promoter enhances bladder cancer progression through the miR-136-5p/Smad3 axis.
      Title: Hypomethylation of PlncRNA-1 promoter enhances bladder cancer progression through the miR-136-5p/Smad3 axis.
    10. patients with advanced stage retinoblastoma had higher levels of PlncRNA-1 expression than patients with early stage retinoblastoma. There was an inverse correlation between PlncRNA-1 expression and CBR3 expression in retinoblastoma tissues, and PlncRNA-1 negatively regulated mRNA and protein expressions of CBR3.
      Title: PlncRNA-1 is overexpressed in retinoblastoma and regulates retinoblastoma cell proliferation and motility through modulating CBR3.
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Other Names

    • CBR3 antisense RNA 1 (non-protein coding)
    • prostate cancer-up-regulated long noncoding RNA 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_038892.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AL542398, AP000689, BI836686
      Related
      ENST00000413862.8

    2. NR_038893.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal exon, compared to variant 1.
      Source sequence(s)
      AP000689, BI836686
      Related
      ENST00000453159.7

    3. NR_038894.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an alternate 3' sequence, compared to variant 1.
      Source sequence(s)
      AP000689, BI836686
      Related
      ENST00000427491.4

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

      Range
      36131767..36156308 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060945.1 Alternate T2T-CHM13v2.0

      Range
      34514794..34539161 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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