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    RASSF8 Ras association domain family member 8 [ Homo sapiens (human) ]

    Gene ID: 11228, updated on 10-Dec-2024

    Summary

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    Official Symbol
    RASSF8provided by HGNC
    Official Full Name
    Ras association domain family member 8provided by HGNC
    Primary source
    HGNC:HGNC:13232
    See related
    Ensembl:ENSG00000123094 MIM:608231; AllianceGenome:HGNC:13232
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HOJ1; C12orf2
    Summary
    This gene encodes a member of the Ras-assocation domain family (RASSF) of tumor suppressor proteins. This gene is essential for maintaining adherens junction function in epithelial cells and has a role in epithelial cell migration. It is a lung tumor suppressor gene candidate. A chromosomal translocation t(12;22)(p11.2;q13.3) leading to the fusion of this gene and the FBLN1 gene is found in a complex type of synpolydactyly. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
    Expression
    Broad expression in testis (RPKM 13.9), endometrium (RPKM 13.0) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RASSF8 in Genome Data Viewer
    Location:
    12p12.1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (25958232..26079889)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (25830796..25952417)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (26111165..26232822)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene thymine-DNA glycosylase pseudogene 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:26038654-26039197 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:26040173-26040831 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_26717 Neighboring gene microRNA 4302 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4295 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4296 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4297 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4298 Neighboring gene RASSF8 antisense RNA 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:26150508-26151264 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:26151265-26152021 Neighboring gene uncharacterized LOC107984501 Neighboring gene uncharacterized LOC124902901 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:26200376-26200975 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4299 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4300 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4301 Neighboring gene basic helix-loop-helix family member e41 Neighboring gene sarcospan Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_26866 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:26379181-26379816 Neighboring gene ITPR2 and SSPN antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6118 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:26398995-26400194 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_26902 Neighboring gene uncharacterized LOC105369705

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Physical map of a 1.5 mb region on 12p11.2 harbouring a synpolydactyly associated chromosomal breakpoint. Debeer P, et al. Eur J Hum Genet, 2000 Aug. PMID 10951517
    2. Identification of RASSF8 as a candidate lung tumor suppressor gene. Falvella FS, et al. Oncogene, 2006 Jun 29. PMID 16462760
    3. RASSF8 regulates progression of cutaneous melanoma through nuclear factor-κb. Wang J, et al. Oncotarget, 2015 Oct 6. PMID 26334503, Free PMC Article
    4. RASSF8 downregulation promotes lymphangiogenesis and metastasis in esophageal squamous cell carcinoma. Zhang L, et al. Oncotarget, 2015 Oct 27. PMID 26439687, Free PMC Article
    5. Tailored modulation of S100A1 and RASSF8 expression by butanediamide augments healing of rotator cuff tears. Lin Y, et al. PeerJ, 2023. PMID 37601265, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tailored modulation of S100A1 and RASSF8 expression by butanediamide augments healing of rotator cuff tears.
      Title: Tailored modulation of S100A1 and RASSF8 expression by butanediamide augments healing of rotator cuff tears.
    2. CircCERS6 Suppresses the Development of Epithelial Ovarian Cancer Through Mediating miR-630/RASSF8.
      Title: CircCERS6 Suppresses the Development of Epithelial Ovarian Cancer Through Mediating miR-630/RASSF8.
    3. RASSF8-AS1 displays low expression in colorectal cancer and up-regulates RASSF8 to suppress cell invasion and migration.
      Title: RASSF8-AS1 displays low expression in colorectal cancer and up-regulates RASSF8 to suppress cell invasion and migration.
    4. data provide evidence that E4BP4 attenuates RASSF8-mediated anti-proliferation and apoptosis, shedding mechanistic insights into RASSF8 down-regulation in breast cancers.
      Title: E4BP4/NFIL3 modulates the epigenetically repressed RAS effector RASSF8 function through histone methyltransferases.
    5. MiR-505 mediated MTX resistance, propagation, cell cycle and metastasis by targeting RASSF8 in colorectal cancer
      Title: MiR-505 mediates methotrexate resistance in colorectal cancer by targeting RASSF8.
    6. The miR-224 played an oncogenic role in the proliferation of NSCLC by direct targeting RASSF8.
      Title: The miR-224 promotes non-small cell lung cancer cell proliferation by directly targeting RASSF8.
    7. RASSF8 knockdown by specific RNAi showed similar effects in cervical cancer cells transfected with miR-224 mimic. Our findings suggest that miR-224 directly targets RASSF8 and thereby acts as a tumor promoter in cervical cancer progression
      Title: Over-Expressed miR-224 Promotes the Progression of Cervical Cancer via Targeting RASSF8.
    8. These results indicate that hypoxia-inducible miR-224 promotes gastric cancer cell growth, migration and invasion by downregulating RASSF8 and acts as an oncogene, implying that inhibition of miR-224 may have potential as a therapeutic target for patients with hypoxic gastric tumors.
      Title: Hypoxia-inducible microRNA-224 promotes the cell growth, migration and invasion by directly targeting RASSF8 in gastric cancer.
    9. RASSF8 acts as a tumor suppressor in squamous cell carcinoma
      Title: RASSF8 downregulation promotes lymphangiogenesis and metastasis in esophageal squamous cell carcinoma.
    10. RASSF8 plays a significant role in suppressing the progression of cutaneous melanoma.
      Title: RASSF8 regulates progression of cutaneous melanoma through nuclear factor-κb.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ11542, DKFZp434O0227

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ras association domain-containing protein 8
    Names
    Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
    carcinoma-associated protein HOJ-1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029077.1 RefSeqGene

      Range
      4652..118839
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001164746.2 → NP_001158218.1  ras association domain-containing protein 8 isoform a

      See identical proteins and their annotated locations for NP_001158218.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2 and 3 encode the same isoform.
      Source sequence(s)
      AC055707, AK292333, AY665468, BE440096, DB055998
      Consensus CDS
      CCDS53765.1
      UniProtKB/Swiss-Prot
      A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
      UniProtKB/TrEMBL
      A8K8G8
      Related
      ENSP00000282884.9, ENST00000282884.13
      Conserved Domains (2) summary
      COG1196
      Location:160 → 351
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd16134
      Location:2 → 83
      RA_RASSF8; Ras-associating (RA) domain found in N-terminal Ras-association domain family 8 (RASSF8)

    2. NM_001164747.2 → NP_001158219.1  ras association domain-containing protein 8 isoform a

      See identical proteins and their annotated locations for NP_001158219.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (a).
      Source sequence(s)
      AC055707, AK290055, AY665468, BE440096
      Consensus CDS
      CCDS53765.1
      UniProtKB/Swiss-Prot
      A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
      UniProtKB/TrEMBL
      A8K8G8
      Related
      ENSP00000439839.1, ENST00000542865.5
      Conserved Domains (2) summary
      COG1196
      Location:160 → 351
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd16134
      Location:2 → 83
      RA_RASSF8; Ras-associating (RA) domain found in N-terminal Ras-association domain family 8 (RASSF8)

    3. NM_001164748.2 → NP_001158220.1  ras association domain-containing protein 8 isoform a

      See identical proteins and their annotated locations for NP_001158220.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (a).
      Source sequence(s)
      AB093206, AC055707, BE440096, DB044325
      Consensus CDS
      CCDS53765.1
      UniProtKB/Swiss-Prot
      A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
      UniProtKB/TrEMBL
      A8K8G8
      Related
      ENSP00000384491.1, ENST00000405154.6
      Conserved Domains (2) summary
      COG1196
      Location:160 → 351
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd16134
      Location:2 → 83
      RA_RASSF8; Ras-associating (RA) domain found in N-terminal Ras-association domain family 8 (RASSF8)

    4. NM_001394094.1 → NP_001381023.1  ras association domain-containing protein 8 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC055707
      Consensus CDS
      CCDS53765.1
      UniProtKB/Swiss-Prot
      A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
      UniProtKB/TrEMBL
      A8K8G8
      Related
      ENSP00000509001.1, ENST00000688511.1
      Conserved Domains (2) summary
      COG1196
      Location:160 → 351
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd16134
      Location:2 → 83
      RA_RASSF8; Ras-associating (RA) domain found in N-terminal Ras-association domain family 8 (RASSF8)

    5. NM_001394095.1 → NP_001381024.1  ras association domain-containing protein 8 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC055707
      Consensus CDS
      CCDS53765.1
      UniProtKB/Swiss-Prot
      A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
      UniProtKB/TrEMBL
      A8K8G8
      Related
      ENSP00000509645.1, ENST00000689434.1
      Conserved Domains (2) summary
      COG1196
      Location:160 → 351
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd16134
      Location:2 → 83
      RA_RASSF8; Ras-associating (RA) domain found in N-terminal Ras-association domain family 8 (RASSF8)

    6. NM_001394096.1 → NP_001381025.1  ras association domain-containing protein 8 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC055707
      Consensus CDS
      CCDS53765.1
      UniProtKB/Swiss-Prot
      A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
      UniProtKB/TrEMBL
      A8K8G8
      Related
      ENSP00000443096.1, ENST00000541490.5
      Conserved Domains (2) summary
      COG1196
      Location:160 → 351
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd16134
      Location:2 → 83
      RA_RASSF8; Ras-associating (RA) domain found in N-terminal Ras-association domain family 8 (RASSF8)

    7. NM_001394097.1 → NP_001381026.1  ras association domain-containing protein 8 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC055707
      Consensus CDS
      CCDS53765.1
      UniProtKB/Swiss-Prot
      A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
      UniProtKB/TrEMBL
      A8K8G8
      Conserved Domains (2) summary
      COG1196
      Location:160 → 351
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd16134
      Location:2 → 83
      RA_RASSF8; Ras-associating (RA) domain found in N-terminal Ras-association domain family 8 (RASSF8)

    8. NM_001394098.1 → NP_001381027.1  ras association domain-containing protein 8 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC055707
      Consensus CDS
      CCDS53765.1
      UniProtKB/Swiss-Prot
      A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
      UniProtKB/TrEMBL
      A8K8G8
      Related
      ENSP00000510086.1, ENST00000689635.1
      Conserved Domains (2) summary
      COG1196
      Location:160 → 351
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd16134
      Location:2 → 83
      RA_RASSF8; Ras-associating (RA) domain found in N-terminal Ras-association domain family 8 (RASSF8)

    9. NM_001394099.1 → NP_001381028.1  ras association domain-containing protein 8 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC055707
      Consensus CDS
      CCDS53765.1
      UniProtKB/Swiss-Prot
      A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
      UniProtKB/TrEMBL
      A8K8G8
      Conserved Domains (2) summary
      COG1196
      Location:160 → 351
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd16134
      Location:2 → 83
      RA_RASSF8; Ras-associating (RA) domain found in N-terminal Ras-association domain family 8 (RASSF8)

    10. NM_001394100.1 → NP_001381029.1  ras association domain-containing protein 8 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC055707
      Consensus CDS
      CCDS53765.1
      UniProtKB/Swiss-Prot
      A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
      UniProtKB/TrEMBL
      A8K8G8
      Conserved Domains (2) summary
      COG1196
      Location:160 → 351
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd16134
      Location:2 → 83
      RA_RASSF8; Ras-associating (RA) domain found in N-terminal Ras-association domain family 8 (RASSF8)

    11. NM_001394101.1 → NP_001381030.1  ras association domain-containing protein 8 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC055707
      Consensus CDS
      CCDS53765.1
      UniProtKB/Swiss-Prot
      A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
      UniProtKB/TrEMBL
      A8K8G8
      Conserved Domains (2) summary
      COG1196
      Location:160 → 351
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd16134
      Location:2 → 83
      RA_RASSF8; Ras-associating (RA) domain found in N-terminal Ras-association domain family 8 (RASSF8)

    12. NM_001394102.1 → NP_001381031.1  ras association domain-containing protein 8 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC055707
      Consensus CDS
      CCDS53765.1
      UniProtKB/Swiss-Prot
      A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
      UniProtKB/TrEMBL
      A8K8G8
      Conserved Domains (2) summary
      COG1196
      Location:160 → 351
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd16134
      Location:2 → 83
      RA_RASSF8; Ras-associating (RA) domain found in N-terminal Ras-association domain family 8 (RASSF8)

    13. NM_007211.5 → NP_009142.2  ras association domain-containing protein 8 isoform b

      See identical proteins and their annotated locations for NP_009142.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in both UTRs and in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AC055707, BC030021
      Consensus CDS
      CCDS8705.1
      UniProtKB/TrEMBL
      A8K8G8
      Related
      ENSP00000370756.3, ENST00000381352.7
      Conserved Domains (2) summary
      COG1196
      Location:160 → 351
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd16134
      Location:2 → 83
      RA_RASSF8; Ras-associating (RA) domain found in N-terminal Ras-association domain family 8 (RASSF8)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      25958232..26079889
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047428189.1 → XP_047284145.1  ras association domain-containing protein 8 isoform X1

      UniProtKB/Swiss-Prot
      A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
      UniProtKB/TrEMBL
      A8K8G8

    2. XM_047428188.1 → XP_047284144.1  ras association domain-containing protein 8 isoform X1

      UniProtKB/Swiss-Prot
      A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
      UniProtKB/TrEMBL
      A8K8G8

    3. XM_047428187.1 → XP_047284143.1  ras association domain-containing protein 8 isoform X1

      UniProtKB/Swiss-Prot
      A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
      UniProtKB/TrEMBL
      A8K8G8

    4. XM_047428191.1 → XP_047284147.1  ras association domain-containing protein 8 isoform X1

      UniProtKB/Swiss-Prot
      A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
      UniProtKB/TrEMBL
      A8K8G8

    5. XM_047428192.1 → XP_047284148.1  ras association domain-containing protein 8 isoform X1

      UniProtKB/Swiss-Prot
      A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
      UniProtKB/TrEMBL
      A8K8G8

    6. XM_047428190.1 → XP_047284146.1  ras association domain-containing protein 8 isoform X1

      UniProtKB/Swiss-Prot
      A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
      UniProtKB/TrEMBL
      A8K8G8

    7. XM_047428186.1 → XP_047284142.1  ras association domain-containing protein 8 isoform X1

      UniProtKB/Swiss-Prot
      A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
      UniProtKB/TrEMBL
      A8K8G8

    8. XM_006719028.1 → XP_006719091.1  ras association domain-containing protein 8 isoform X1

      See identical proteins and their annotated locations for XP_006719091.1

      UniProtKB/Swiss-Prot
      A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
      UniProtKB/TrEMBL
      A8K8G8
      Conserved Domains (2) summary
      COG1196
      Location:160 → 351
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd16134
      Location:2 → 83
      RA_RASSF8; Ras-associating (RA) domain found in N-terminal Ras-association domain family 8 (RASSF8)

    9. XM_024448820.2 → XP_024304588.1  ras association domain-containing protein 8 isoform X1

      UniProtKB/Swiss-Prot
      A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
      UniProtKB/TrEMBL
      A8K8G8
      Conserved Domains (2) summary
      COG1196
      Location:160 → 351
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd16134
      Location:2 → 83
      RA_RASSF8; Ras-associating (RA) domain found in N-terminal Ras-association domain family 8 (RASSF8)

    10. XM_006719027.3 → XP_006719090.1  ras association domain-containing protein 8 isoform X1

      See identical proteins and their annotated locations for XP_006719090.1

      UniProtKB/Swiss-Prot
      A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
      UniProtKB/TrEMBL
      A8K8G8
      Conserved Domains (2) summary
      COG1196
      Location:160 → 351
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd16134
      Location:2 → 83
      RA_RASSF8; Ras-associating (RA) domain found in N-terminal Ras-association domain family 8 (RASSF8)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      25830796..25952417
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054370930.1 → XP_054226905.1  ras association domain-containing protein 8 isoform X1

      UniProtKB/Swiss-Prot
      A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
      UniProtKB/TrEMBL
      A8K8G8

    2. XM_054370931.1 → XP_054226906.1  ras association domain-containing protein 8 isoform X1

      UniProtKB/Swiss-Prot
      A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
      UniProtKB/TrEMBL
      A8K8G8

    3. XM_054370932.1 → XP_054226907.1  ras association domain-containing protein 8 isoform X1

      UniProtKB/Swiss-Prot
      A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
      UniProtKB/TrEMBL
      A8K8G8

    4. XM_054370925.1 → XP_054226900.1  ras association domain-containing protein 8 isoform X1

      UniProtKB/Swiss-Prot
      A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
      UniProtKB/TrEMBL
      A8K8G8

    5. XM_054370929.1 → XP_054226904.1  ras association domain-containing protein 8 isoform X1

      UniProtKB/Swiss-Prot
      A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
      UniProtKB/TrEMBL
      A8K8G8

    6. XM_054370926.1 → XP_054226901.1  ras association domain-containing protein 8 isoform X1

      UniProtKB/Swiss-Prot
      A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
      UniProtKB/TrEMBL
      A8K8G8

    7. XM_054370927.1 → XP_054226902.1  ras association domain-containing protein 8 isoform X1

      UniProtKB/Swiss-Prot
      A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
      UniProtKB/TrEMBL
      A8K8G8

    8. XM_054370928.1 → XP_054226903.1  ras association domain-containing protein 8 isoform X1

      UniProtKB/Swiss-Prot
      A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
      UniProtKB/TrEMBL
      A8K8G8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NHQ8.2 GenPept UniProtKB/Swiss-Prot:Q8NHQ8

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