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    LYPD6 LY6/PLAUR domain containing 6 [ Homo sapiens (human) ]

    Gene ID: 130574, updated on 10-Dec-2024

    Summary

    Official Symbol
    LYPD6provided by HGNC
    Official Full Name
    LY6/PLAUR domain containing 6provided by HGNC
    Primary source
    HGNC:HGNC:28751
    See related
    Ensembl:ENSG00000187123 MIM:613359; AllianceGenome:HGNC:28751
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Members of the LY6 protein family (see SLURP1; MIM 606119), such as LYPD6, have at least one 80-amino acid LU domain that contains 10 conserved cysteines with a defined disulfide-bonding pattern (Zhang et al., 2010 [PubMed 19653121]).[supplied by OMIM, Apr 2010]
    Expression
    Biased expression in gall bladder (RPKM 7.3), placenta (RPKM 6.8) and 12 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See LYPD6 in Genome Data Viewer
    Location:
    2q23.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (149329985..149486378)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (149780390..149936801)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (150186499..150330652)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373679 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12004 Neighboring gene family with sequence similarity 8 member A3, pseudogene Neighboring gene uncharacterized LOC124906190 Neighboring gene microRNA 9899 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:150274403-150274924 Neighboring gene NANOG hESC enhancer GRCh37_chr2:150306659-150307199 Neighboring gene ribosomal protein L17 pseudogene 13 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:150363112-150363636 Neighboring gene Sharpr-MPRA regulatory region 14986 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:150443500-150444699 Neighboring gene MMADHC divergent transcript Neighboring gene metabolism of cobalamin associated D Neighboring gene RNA, U6 small nuclear 601, pseudogene

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Clone Names

    • MGC52057

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in dendrite  
    located_in extracellular region  
    located_in membrane raft  
    located_in perikaryon  
    located_in plasma membrane  
    located_in side of membrane  
    located_in synapse  

    General protein information

    Preferred Names
    ly6/PLAUR domain-containing protein 6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195685.2 → NP_001182614.1  ly6/PLAUR domain-containing protein 6 precursor

      See identical proteins and their annotated locations for NP_001182614.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC007394
      Consensus CDS
      CCDS2188.1
      UniProtKB/Swiss-Prot
      B3KWC0, Q4G121, Q53TR3, Q659B1, Q86Y78
      Related
      ENSP00000386413.1, ENST00000409381.5
      Conserved Domains (1) summary
      pfam16975
      Location:41 → 145
      UPAR_LY6_2; Ly6/PLAUR domain-containing protein 6, Lypd6
    2. NM_194317.5 → NP_919298.1  ly6/PLAUR domain-containing protein 6 precursor

      See identical proteins and their annotated locations for NP_919298.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different segment for its 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC007394
      Consensus CDS
      CCDS2188.1
      UniProtKB/Swiss-Prot
      B3KWC0, Q4G121, Q53TR3, Q659B1, Q86Y78
      Related
      ENSP00000334463.4, ENST00000334166.9
      Conserved Domains (1) summary
      pfam16975
      Location:41 → 145
      UPAR_LY6_2; Ly6/PLAUR domain-containing protein 6, Lypd6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      149329985..149486378
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024452699.2 → XP_024308467.1  ly6/PLAUR domain-containing protein 6 isoform X1

      UniProtKB/Swiss-Prot
      B3KWC0, Q4G121, Q53TR3, Q659B1, Q86Y78
      Related
      ENSP00000498455.1, ENST00000651933.1
      Conserved Domains (1) summary
      pfam16975
      Location:41 → 145
      UPAR_LY6_2; Ly6/PLAUR domain-containing protein 6, Lypd6
    2. XM_024452701.2 → XP_024308469.1  ly6/PLAUR domain-containing protein 6 isoform X1

      UniProtKB/Swiss-Prot
      B3KWC0, Q4G121, Q53TR3, Q659B1, Q86Y78
      Conserved Domains (1) summary
      pfam16975
      Location:41 → 145
      UPAR_LY6_2; Ly6/PLAUR domain-containing protein 6, Lypd6
    3. XM_047443400.1 → XP_047299356.1  ly6/PLAUR domain-containing protein 6 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      149780390..149936801
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340547.1 → XP_054196522.1  ly6/PLAUR domain-containing protein 6 isoform X1

      UniProtKB/Swiss-Prot
      B3KWC0, Q4G121, Q53TR3, Q659B1, Q86Y78
    2. XM_054340548.1 → XP_054196523.1  ly6/PLAUR domain-containing protein 6 isoform X1

      UniProtKB/Swiss-Prot
      B3KWC0, Q4G121, Q53TR3, Q659B1, Q86Y78
    3. XM_054340549.1 → XP_054196524.1  ly6/PLAUR domain-containing protein 6 isoform X2

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