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    VSTM4 V-set and transmembrane domain containing 4 [ Homo sapiens (human) ]

    Gene ID: 196740, updated on 10-Dec-2024

    Summary

    Official Symbol
    VSTM4provided by HGNC
    Official Full Name
    V-set and transmembrane domain containing 4provided by HGNC
    Primary source
    HGNC:HGNC:26470
    See related
    Ensembl:ENSG00000165633 AllianceGenome:HGNC:26470
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C10orf72
    Summary
    Predicted to act upstream of or within several processes, including endothelial cell proliferation; retina blood vessel maintenance; and vasculature development. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in adrenal (RPKM 18.4), ovary (RPKM 14.7) and 19 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See VSTM4 in Genome Data Viewer
    Location:
    10q11.23
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (49014236..49115522, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (49863442..49964410, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (50222281..50323567, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene WDFY family member 4 Neighboring gene leucine rich repeat containing 18 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:50156438-50157637 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:50160179-50160678 Neighboring gene uncharacterized LOC105378298 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:50219965-50220220 Neighboring gene microRNA 4294 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3344 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3345 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:50264962-50265148 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:50316573-50317551 Neighboring gene uncharacterized LOC124902545 Neighboring gene FAM170B antisense RNA 1 Neighboring gene family with sequence similarity 170 member B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (10 hits/1267 screens)

    EBI GWAS Catalog

    Description
    Genome-wide meta-analysis identifies new susceptibility loci for migraine.
    EBI GWAS Catalog

    Interactions

    General gene information

    Clone Names

    • FLJ31737, MGC44086

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in endothelial cell migration  
    involved_in endothelial cell proliferation  
    involved_in retina blood vessel maintenance  
    involved_in retina vasculature development in camera-type eye  
    involved_in sprouting angiogenesis  
    involved_in vasodilation  
    Component Evidence Code Pubs
    located_in extracellular region  
    is_active_in membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    V-set and transmembrane domain-containing protein 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031746.5NP_001026916.2  V-set and transmembrane domain-containing protein 4 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001026916.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC060234, AK056299, AK297931, AW058485, BC041414, HY112498
      Consensus CDS
      CCDS31198.1
      UniProtKB/Swiss-Prot
      B4DNI6, Q8IW00, Q96MX7
      Related
      ENSP00000331062.3, ENST00000332853.9
    2. NM_144984.4NP_659421.1  V-set and transmembrane domain-containing protein 4 isoform 2 precursor

      See identical proteins and their annotated locations for NP_659421.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK056299, HY112498
      Consensus CDS
      CCDS7228.1
      UniProtKB/Swiss-Prot
      Q8IW00
      Related
      ENSP00000298454.3, ENST00000298454.3

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      49014236..49115522 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047424711.1XP_047280667.1  V-set and transmembrane domain-containing protein 4 isoform X2

    2. XM_017015827.3XP_016871316.1  V-set and transmembrane domain-containing protein 4 isoform X1

    RNA

    1. XR_001747052.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      49863442..49964410 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364993.1XP_054220968.1  V-set and transmembrane domain-containing protein 4 isoform X2

    2. XM_054364992.1XP_054220967.1  V-set and transmembrane domain-containing protein 4 isoform X1

    RNA

    1. XR_008488174.1 RNA Sequence

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