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    Fbxw10 F-box and WD-40 domain protein 10 [ Mus musculus (house mouse) ]

    Gene ID: 213980, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Fbxw10provided by MGI
    Official Full Name
    F-box and WD-40 domain protein 10provided by MGI
    Primary source
    MGI:MGI:3052463
    See related
    Ensembl:ENSMUSG00000090173 AllianceGenome:MGI:3052463
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HREP; Fbw10; SM25H2; SM2SH2
    Summary
    Acts upstream of or within inflammatory response; response to wounding; and tissue regeneration. Orthologous to several human genes including FBXW10 (F-box and WD repeat domain containing 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 31.0) and thymus adult (RPKM 1.3) See more
    Orthologs
    human all
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    Genomic context

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    See Fbxw10 in Genome Data Viewer
    Location:
    11 B2; 11 38.78 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (62737893..62768290)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (62847067..62877464)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 286 Neighboring gene predicted gene, 24151 Neighboring gene tripartite motif-containing 16 Neighboring gene STARR-seq mESC enhancer starr_29718 Neighboring gene STARR-seq mESC enhancer starr_29719 Neighboring gene STARR-positive B cell enhancer ABC_E1826 Neighboring gene trans-golgi network vesicle protein 23B Neighboring gene trans-golgi network vesicle protein 23B, opposite strand

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Elevated FBXW10 drives hepatocellular carcinoma tumorigenesis via AR-VRK2 phosphorylation-dependent GAPDH ubiquitination in male transgenic mice. Lin XT, et al. Cell Rep, 2023 Jul 25. PMID 37450367
    2. FBXW10 promotes hepatocarcinogenesis in male patients and mice. Luo YD, et al. Carcinogenesis, 2020 Jul 10. PMID 31400758
    3. FBXW10-S6K1 promotes ANXA2 polyubiquitination and KRAS activation to drive hepatocellular carcinoma development in males. Liu ZY, et al. Cancer Lett, 2023 Jul 10. PMID 37277019
    4. The nuclear localization pattern and interaction partners of GTF2IRD1 demonstrate a role in chromatin regulation. Carmona-Mora P, et al. Hum Genet, 2015 Oct. PMID 26275350
    5. Systematic analysis and nomenclature of mammalian F-box proteins. Jin J, et al. Genes Dev, 2004 Nov 1. PMID 15520277, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Elevated FBXW10 drives hepatocellular carcinoma tumorigenesis via AR-VRK2 phosphorylation-dependent GAPDH ubiquitination in male transgenic mice.
      Title: Elevated FBXW10 drives hepatocellular carcinoma tumorigenesis via AR-VRK2 phosphorylation-dependent GAPDH ubiquitination in male transgenic mice.
    2. FBXW10 promotes hepatocarcinogenesis in male patients and mice.
      Title: FBXW10 promotes hepatocarcinogenesis in male patients and mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to wounding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within tissue regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    F-box/WD repeat-containing protein 10
    Names
    F-box and WD-40 domain-containing protein 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033669.3 → NP_001028841.2  F-box/WD repeat-containing protein 10 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL645847
      Consensus CDS
      CCDS24833.2
      UniProtKB/TrEMBL
      B2RUM0, B7ZC91
      Related
      ENSMUSP00000117872.2, ENSMUST00000150989.8
      Conserved Domains (4) summary
      COG2319
      Location:434 → 657
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:423 → 687
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam00646
      Location:281 → 324
      F-box; F-box domain
      sd00039
      Location:462 → 498
      7WD40; WD40 repeat [structural motif]

    2. NM_001291441.2 → NP_001278370.1  F-box/WD repeat-containing protein 10 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL645847
      Consensus CDS
      CCDS78968.1
      UniProtKB/TrEMBL
      B2RUM0, H3BLP9
      Related
      ENSMUSP00000135870.2, ENSMUST00000176577.2
      Conserved Domains (4) summary
      COG2319
      Location:434 → 657
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:423 → 657
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam00646
      Location:281 → 324
      F-box; F-box domain
      sd00039
      Location:462 → 498
      7WD40; WD40 repeat [structural motif]

    3. NM_001404775.1 → NP_001391704.1  F-box/WD repeat-containing protein 10 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL645847

    4. NM_001404776.1 → NP_001391705.1  F-box/WD repeat-containing protein 10 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL645847

    5. NM_001404777.1 → NP_001391706.1  F-box/WD repeat-containing protein 10 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL645847

    6. NM_001404778.1 → NP_001391707.1  F-box/WD repeat-containing protein 10 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL645847

    RNA

    1. NR_175864.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL645847
      Related
      ENSMUST00000177336.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      62737893..62768290
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532782.2 → XP_006532845.1  F-box/WD repeat-containing protein 10 isoform X1

      UniProtKB/TrEMBL
      B2RUM0
      Conserved Domains (3) summary
      sd00039
      Location:436 → 469
      7WD40; WD40 repeat [structural motif]
      pfam00646
      Location:281 → 324
      F-box; F-box domain
      cl29593
      Location:418 → 620
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. XR_001779946.2 RNA Sequence

    2. XR_001779947.2 RNA Sequence

    3. XR_879557.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5SUS0.1 GenPept UniProtKB/Swiss-Prot:Q5SUS0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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