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    ZBTB10 zinc finger and BTB domain containing 10 [ Homo sapiens (human) ]

    Gene ID: 65986, updated on 10-Dec-2024

    Summary

    Official Symbol
    ZBTB10provided by HGNC
    Official Full Name
    zinc finger and BTB domain containing 10provided by HGNC
    Primary source
    HGNC:HGNC:30953
    See related
    Ensembl:ENSG00000205189 MIM:618576; AllianceGenome:HGNC:30953
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RINZF
    Summary
    Enables telomeric DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Located in chromosome, telomeric region and nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in prostate (RPKM 6.2), placenta (RPKM 5.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZBTB10 in Genome Data Viewer
    Location:
    8q21.13
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (80485593..80526265)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (80917153..80957852)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (81397828..81438500)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375922 Neighboring gene uncharacterized LOC105375921 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27568 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:81398027-81398597 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:81398598-81399168 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19324 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:81415452-81415952 Neighboring gene long intergenic non-protein coding RNA 2986 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:81470238-81471437 Neighboring gene ribosomal protein SA pseudogene 47

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.
    EBI GWAS Catalog
    A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
    EBI GWAS Catalog
    Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis.
    EBI GWAS Catalog
    Novel associations for hypothyroidism include known autoimmune risk loci.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ12752

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables telomeric DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    zinc finger and BTB domain-containing protein 10
    Names
    zinc finger protein RIN ZF
    zinc finger protein RINZF

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105539.3NP_001099009.1  zinc finger and BTB domain-containing protein 10 isoform a

      See identical proteins and their annotated locations for NP_001099009.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC009812, AI627858, BC050061, BC127098
      Consensus CDS
      CCDS47880.1
      UniProtKB/Swiss-Prot
      A4FVD0, Q86W96, Q8IXI9, Q96DT7, Q96MH9
      UniProtKB/TrEMBL
      A8E4L4
      Related
      ENSP00000412036.3, ENST00000455036.8
      Conserved Domains (5) summary
      smart00597
      Location:249316
      ZnF_TTF; zinc finger in transposases and transcription factors
      sd00017
      Location:724744
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18201
      Location:343464
      BTB_POZ_ZBTB10; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10)
      pfam13465
      Location:737761
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:722746
      zf-H2C2_5; C2H2-type zinc-finger domain
    2. NM_001277145.2NP_001264074.1  zinc finger and BTB domain-containing protein 10 isoform c

      See identical proteins and their annotated locations for NP_001264074.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate exon in the 5' UTR and coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AC009812, AI627858, AK056913
      Consensus CDS
      CCDS64920.1
      UniProtKB/Swiss-Prot
      Q96DT7
      Related
      ENSP00000368384.4, ENST00000379091.8
      Conserved Domains (4) summary
      sd00017
      Location:432452
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl38908
      Location:51172
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam13465
      Location:445469
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:430454
      zf-H2C2_5; C2H2-type zinc-finger domain
    3. NM_023929.5NP_076418.3  zinc finger and BTB domain-containing protein 10 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a segment in an internal exon, but maintains the reading frame, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AC009812, AI627858, AK022814, BC127098
      UniProtKB/Swiss-Prot
      Q96DT7
      UniProtKB/TrEMBL
      Q9H9H3
      Related
      ENSP00000416134.2, ENST00000426744.5
      Conserved Domains (6) summary
      smart00225
      Location:365461
      BTB; Broad-Complex, Tramtrack and Bric a brac
      smart00597
      Location:249316
      ZnF_TTF; zinc finger in transposases and transcription factors
      sd00017
      Location:700720
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:354460
      BTB; BTB/POZ domain
      pfam13465
      Location:713737
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:698720
      zf-H2C2_5; C2H2-type zinc-finger domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      80485593..80526265
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      80917153..80957852
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)