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    Tnnt3 troponin T3, skeletal, fast [ Mus musculus (house mouse) ]

    Gene ID: 21957, updated on 27-Dec-2024

    Summary

    Official Symbol
    Tnnt3provided by MGI
    Official Full Name
    troponin T3, skeletal, fastprovided by MGI
    Primary source
    MGI:MGI:109550
    See related
    Ensembl:ENSMUSG00000061723 AllianceGenome:MGI:109550
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    fTnT
    Summary
    Predicted to enable calcium-dependent protein binding activity and cytoskeletal protein binding activity. Predicted to contribute to actin binding activity. Predicted to be involved in several processes, including positive regulation of calcium-dependent ATPase activity; sarcomere organization; and skeletal muscle contraction. Predicted to be part of troponin complex. Is expressed in several structures, including diaphragm; heart; lower jaw; musculature; and urinary system. Human ortholog(s) of this gene implicated in distal arthrogryposis type 2B and distal arthrogryposis type 2B2. Orthologous to human TNNT3 (troponin T3, fast skeletal type). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in mammary gland adult (RPKM 50.5), bladder adult (RPKM 9.6) and 4 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tnnt3 in Genome Data Viewer
    Location:
    7 F5; 7 87.94 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (142052530..142069746)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (142498771..142516213)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20508 Neighboring gene troponin I, skeletal, fast 2 Neighboring gene STARR-positive B cell enhancer ABC_E10483 Neighboring gene lymphocyte specific 1 Neighboring gene proline rich 33 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:149724284-149724471 Neighboring gene mitochondrial ribosomal protein L23 Neighboring gene H19/Igf2 enhancer region Neighboring gene non-coding transcript 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tropomyosin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    contributes_to tropomyosin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tropomyosin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables troponin C binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables troponin C binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables troponin I binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables troponin I binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in positive regulation of calcium-dependent ATPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of ATP-dependent activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of striated muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sarcomere organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in skeletal muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in skeletal muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of troponin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of troponin complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of troponin complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    troponin T, fast skeletal muscle
    Names
    fast skeletal muscle troponin T
    fast skeletal muscle troponin T3
    skeletal muscle fast-twitch TnT
    tnTf

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163664.1NP_001157136.1  troponin T, fast skeletal muscle isoform 1

      See identical proteins and their annotated locations for NP_001157136.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AI037743, AI173874, AI574395, CK791812, DV049834
      Consensus CDS
      CCDS52452.1
      UniProtKB/Swiss-Prot
      A2A6H7, A2A6H8, A2A6H9, A2A6I1, A2A6I2, A2A6I4, A2A6I6, A2A6I7, A2A6I9, O35575, O35576, O35577, O35578, O35579, O35580, O35581, O35582, O35583, O35584, O35585, P97456, Q99L89, Q9QZ46, Q9QZ47
      UniProtKB/TrEMBL
      Z4YNB2
      Related
      ENSMUSP00000136278.2, ENSMUST00000179658.8
      Conserved Domains (1) summary
      pfam00992
      Location:76211
      Troponin
    2. NM_001163665.1NP_001157137.1  troponin T, fast skeletal muscle isoform 2

      See identical proteins and their annotated locations for NP_001157137.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon and contains another alternate exon compared to variant 1. The resulting isoform (2) is the same size but has an alternate internal segment compared to isoform 1.
      Source sequence(s)
      AI037743, AI173874, AI574395, CB196352, DV049834
      Consensus CDS
      CCDS52451.1
      UniProtKB/Swiss-Prot
      A2A6H7, A2A6H8, A2A6H9, A2A6I1, A2A6I2, A2A6I4, A2A6I6, A2A6I7, A2A6I9, O35575, O35576, O35577, O35578, O35579, O35580, O35581, O35582, O35583, O35584, O35585, P97456, Q99L89, Q9QZ46, Q9QZ47
      UniProtKB/TrEMBL
      A0A0R4J1B0
      Related
      ENSMUSP00000101578.4, ENSMUST00000105958.10
      Conserved Domains (1) summary
      pfam00992
      Location:76211
      Troponin
    3. NM_001163666.1NP_001157138.1  troponin T, fast skeletal muscle isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AI037743, AI746973, CK791812, DV049834
      Consensus CDS
      CCDS52456.1
      UniProtKB/TrEMBL
      Z4YKG8, Z4YKH8
      Related
      ENSMUSP00000101574.4, ENSMUST00000105954.10
      Conserved Domains (1) summary
      pfam00992
      Location:67202
      Troponin
    4. NM_001163667.1NP_001157139.1  troponin T, fast skeletal muscle isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AI037743, BY766323, CK791812, DV049834
      Consensus CDS
      CCDS52454.1
      UniProtKB/Swiss-Prot
      A2A6H7, A2A6H8, A2A6H9, A2A6I1, A2A6I2, A2A6I4, A2A6I6, A2A6I7, A2A6I9, O35575, O35576, O35577, O35578, O35579, O35580, O35581, O35582, O35583, O35584, O35585, P97456, Q99L89, Q9QZ46, Q9QZ47
      UniProtKB/TrEMBL
      Z4YJU0
      Related
      ENSMUSP00000077587.9, ENSMUST00000078497.15
      Conserved Domains (1) summary
      pfam00992
      Location:72207
      Troponin
    5. NM_001163668.1NP_001157140.1  troponin T, fast skeletal muscle isoform 6

      See identical proteins and their annotated locations for NP_001157140.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (6) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AA771596, AI037743, CK791812, DV049834, U77779
      Consensus CDS
      CCDS52455.1
      UniProtKB/TrEMBL
      A2A6H6, Z4YKH8
      Related
      ENSMUSP00000101575.2, ENSMUST00000105955.8
      Conserved Domains (1) summary
      pfam00992
      Location:59195
      Troponin
    6. NM_001163669.1NP_001157141.1  troponin T, fast skeletal muscle isoform 5

      See identical proteins and their annotated locations for NP_001157141.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AA028290, AI037743, CK791812, DV049834
      Consensus CDS
      CCDS52453.1
      UniProtKB/TrEMBL
      Z4YKF8, Z4YKH8
      Related
      ENSMUSP00000101572.4, ENSMUST00000105952.10
      Conserved Domains (1) summary
      pfam00992
      Location:63199
      Troponin
    7. NM_001163670.1NP_001157142.1  troponin T, fast skeletal muscle isoform 8

      See identical proteins and their annotated locations for NP_001157142.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) lacks four alternate in-frame exons compared to variant 1. The resulting isoform (8) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AA754928, AI037743, AK003147, DV049834
      Consensus CDS
      CCDS52457.1
      UniProtKB/TrEMBL
      A2A6J0, Z4YKH8
      Related
      ENSMUSP00000101569.2, ENSMUST00000105949.8
      Conserved Domains (1) summary
      pfam00992
      Location:48184
      Troponin
    8. NM_001347546.1NP_001334475.1  troponin T, fast skeletal muscle isoform 9

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (9) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AL603651
      Consensus CDS
      CCDS85475.1
      UniProtKB/TrEMBL
      Z4YKG3, Z4YKH8
      Related
      ENSMUSP00000101573.4, ENSMUST00000105953.10
      Conserved Domains (1) summary
      pfam00992
      Location:66201
      Troponin
    9. NM_001347547.1NP_001334476.1  troponin T, fast skeletal muscle isoform 10

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) lacks three alternate exons and contains another alternate exon compared to variant 1. The resulting isoform (10) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AL603651
      Consensus CDS
      CCDS85471.1
      UniProtKB/TrEMBL
      A0A0R4J1A8, Z4YKH8
      Related
      ENSMUSP00000127854.3, ENSMUST00000169299.9
      Conserved Domains (1) summary
      pfam00992
      Location:58194
      Troponin
    10. NM_001347548.1NP_001334477.1  troponin T, fast skeletal muscle isoform 11

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) lacks three alternate in-frame exons compared to variant 1. The resulting isoform (11) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AL603651
      Consensus CDS
      CCDS85473.1
      UniProtKB/TrEMBL
      A2A6J1, Z4YKH8
      Related
      ENSMUSP00000101564.2, ENSMUST00000105944.3
      Conserved Domains (1) summary
      pfam00992
      Location:54190
      Troponin
    11. NM_001347549.1NP_001334478.1  troponin T, fast skeletal muscle isoform 12

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12) lacks four alternate exons and contains another alternate exon compared to variant 1. The resulting isoform (12) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AL603651
      Consensus CDS
      CCDS85472.1
      UniProtKB/TrEMBL
      A2A6I0, Z4YKH8
      Related
      ENSMUSP00000101568.2, ENSMUST00000105948.8
      Conserved Domains (1) summary
      pfam00992
      Location:54190
      Troponin
    12. NM_001347550.1NP_001334479.1  troponin T, fast skeletal muscle isoform 13

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13) lacks four alternate exons and contains another alternate exon compared to variant 1. The resulting isoform (13) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AL603651
      Consensus CDS
      CCDS85474.1
      UniProtKB/TrEMBL
      A2A6I3, Z4YKH8
      Related
      ENSMUSP00000101561.2, ENSMUST00000105941.8
      Conserved Domains (1) summary
      pfam00992
      Location:52188
      Troponin
    13. NM_001347551.1NP_001334480.1  troponin T, fast skeletal muscle isoform 14

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14) lacks five alternate in-frame exons compared to variant 1. The resulting isoform (14) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AL603651
      Consensus CDS
      CCDS85477.1
      UniProtKB/TrEMBL
      A2A6I8, Z4YKH8
      Related
      ENSMUSP00000101562.2, ENSMUST00000105942.8
      Conserved Domains (1) summary
      pfam00992
      Location:43178
      Troponin
    14. NM_001347552.1NP_001334481.1  troponin T, fast skeletal muscle isoform 15

      Status: VALIDATED

      Description
      Transcript Variant: This variant (15) lacks six alternate exons and contains another alternate exon compared to variant 1. The resulting isoform (15) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AL603651
      Consensus CDS
      CCDS85476.1
      UniProtKB/TrEMBL
      A2A6I5, Z4YKH8
      Related
      ENSMUSP00000101563.2, ENSMUST00000105943.8
      Conserved Domains (1) summary
      pfam00992
      Location:43178
      Troponin
    15. NM_001360157.1NP_001347086.1  troponin T, fast skeletal muscle isoform 16

      Status: VALIDATED

      Description
      Transcript Variant: This variant (16) lacks four alternate exons and contains another alternate exon compared to variant 1. The resulting isoform (16) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AL603651
      UniProtKB/TrEMBL
      Z4YKH8
      Conserved Domains (1) summary
      pfam00992
      Location:61196
      Troponin
    16. NM_001360158.1NP_001347087.1  troponin T, fast skeletal muscle isoform 17

      Status: VALIDATED

      Description
      Transcript Variant: This variant (17) lacks three alternate exons and contains another alternate exon compared to variant 1. The resulting isoform (17) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AL603651
      UniProtKB/TrEMBL
      Z4YKH8
      Conserved Domains (1) summary
      pfam00992
      Location:59195
      Troponin
    17. NM_011620.3NP_035750.2  troponin T, fast skeletal muscle isoform 7

      See identical proteins and their annotated locations for NP_035750.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks three alternate in-frame exons compared to variant 1. The resulting isoform (7) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AI037743, AI322331, DV049834, U77779
      Consensus CDS
      CCDS22031.1
      UniProtKB/TrEMBL
      A0A0R4J1B1, Z4YKH8
      Related
      ENSMUSP00000073815.7, ENSMUST00000074187.13
      Conserved Domains (1) summary
      pfam00992
      Location:52188
      Troponin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      142052530..142069746
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508584.2XP_006508647.1  troponin T, fast skeletal muscle isoform X5

      See identical proteins and their annotated locations for XP_006508647.1

      UniProtKB/TrEMBL
      Z4YKD9, Z4YKH8
      Related
      ENSMUSP00000101567.2, ENSMUST00000105947.8
      Conserved Domains (1) summary
      pfam00992
      Location:63199
      Troponin
    2. XM_006508588.2XP_006508651.1  troponin T, fast skeletal muscle isoform X10

      See identical proteins and their annotated locations for XP_006508651.1

      UniProtKB/TrEMBL
      Z4YKH8
      Conserved Domains (1) summary
      pfam00992
      Location:58194
      Troponin
    3. XM_036152902.1XP_036008795.1  troponin T, fast skeletal muscle isoform X8

      UniProtKB/TrEMBL
      Z4YKH8
      Conserved Domains (1) summary
      pfam00992
      Location:58194
      Troponin
    4. XM_036152896.1XP_036008789.1  troponin T, fast skeletal muscle isoform X1

      UniProtKB/Swiss-Prot
      A2A6H7, A2A6H8, A2A6H9, A2A6I1, A2A6I2, A2A6I4, A2A6I6, A2A6I7, A2A6I9, O35575, O35576, O35577, O35578, O35579, O35580, O35581, O35582, O35583, O35584, O35585, P97456, Q99L89, Q9QZ46, Q9QZ47
      Conserved Domains (1) summary
      pfam00992
      Location:71207
      Troponin
    5. XM_036152903.1XP_036008796.1  troponin T, fast skeletal muscle isoform X9

      UniProtKB/TrEMBL
      Z4YKH8
      Conserved Domains (1) summary
      pfam00992
      Location:58194
      Troponin
    6. XM_036152904.1XP_036008797.1  troponin T, fast skeletal muscle isoform X13

      UniProtKB/TrEMBL
      Z4YKH8
      Conserved Domains (1) summary
      pfam00992
      Location:53189
      Troponin
    7. XM_036152905.1XP_036008798.1  troponin T, fast skeletal muscle isoform X14

      UniProtKB/TrEMBL
      Z4YKH8
      Conserved Domains (1) summary
      pfam00992
      Location:53189
      Troponin
    8. XM_036152908.1XP_036008801.1  troponin T, fast skeletal muscle isoform X17

      UniProtKB/TrEMBL
      Z4YKH8
      Conserved Domains (1) summary
      pfam00992
      Location:49185
      Troponin
    9. XM_036152898.1XP_036008791.1  troponin T, fast skeletal muscle isoform X3

      UniProtKB/Swiss-Prot
      A2A6H7, A2A6H8, A2A6H9, A2A6I1, A2A6I2, A2A6I4, A2A6I6, A2A6I7, A2A6I9, O35575, O35576, O35577, O35578, O35579, O35580, O35581, O35582, O35583, O35584, O35585, P97456, Q99L89, Q9QZ46, Q9QZ47
      Conserved Domains (1) summary
      pfam00992
      Location:70206
      Troponin
    10. XM_036152901.1XP_036008794.1  troponin T, fast skeletal muscle isoform X7

      UniProtKB/TrEMBL
      Z4YKH8
      Conserved Domains (1) summary
      pfam00992
      Location:61197
      Troponin
    11. XM_036152909.1XP_036008802.1  troponin T, fast skeletal muscle isoform X18

      UniProtKB/TrEMBL
      Z4YKH8
      Related
      ENSMUSP00000116087.2, ENSMUST00000146804.8
      Conserved Domains (1) summary
      pfam00992
      Location:48184
      Troponin
    12. XM_036152897.1XP_036008790.1  troponin T, fast skeletal muscle isoform X2

      UniProtKB/TrEMBL
      Z4YKH8
      Conserved Domains (1) summary
      pfam00992
      Location:70206
      Troponin
    13. XM_006508591.2XP_006508654.1  troponin T, fast skeletal muscle isoform X12

      See identical proteins and their annotated locations for XP_006508654.1

      UniProtKB/TrEMBL
      Z4YKH8
      Conserved Domains (1) summary
      pfam00992
      Location:57193
      Troponin
    14. XM_006508590.2XP_006508653.1  troponin T, fast skeletal muscle isoform X11

      See identical proteins and their annotated locations for XP_006508653.1

      UniProtKB/TrEMBL
      Z4YKH8
      Conserved Domains (1) summary
      pfam00992
      Location:57193
      Troponin
    15. XM_036152906.1XP_036008799.1  troponin T, fast skeletal muscle isoform X15

      UniProtKB/TrEMBL
      A0A0R4J1B1, Z4YKH8
      Conserved Domains (1) summary
      pfam00992
      Location:52188
      Troponin
    16. XM_036152899.1XP_036008792.1  troponin T, fast skeletal muscle isoform X4

      UniProtKB/TrEMBL
      Z4YKH8
      Conserved Domains (1) summary
      pfam00992
      Location:65201
      Troponin
    17. XM_036152907.1XP_036008800.1  troponin T, fast skeletal muscle isoform X16

      UniProtKB/TrEMBL
      Z4YKH8
      Conserved Domains (1) summary
      pfam00992
      Location:52188
      Troponin
    18. XM_036152911.1XP_036008804.1  troponin T, fast skeletal muscle isoform X20

      UniProtKB/TrEMBL
      Z4YKH8
      Conserved Domains (1) summary
      pfam00992
      Location:47183
      Troponin
    19. XM_036152910.1XP_036008803.1  troponin T, fast skeletal muscle isoform X19

      UniProtKB/TrEMBL
      Z4YKH8
      Conserved Domains (1) summary
      pfam00992
      Location:47183
      Troponin
    20. XM_036152900.1XP_036008793.1  troponin T, fast skeletal muscle isoform X6

      UniProtKB/TrEMBL
      Z4YKH8
      Conserved Domains (1) summary
      pfam00992
      Location:61197
      Troponin