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    Klra2 killer cell lectin-like receptor, subfamily A, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 16633, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Klra2provided by MGI
    Official Full Name
    killer cell lectin-like receptor, subfamily A, member 2provided by MGI
    Primary source
    MGI:MGI:101906
    See related
    Ensembl:ENSMUSG00000030187 AllianceGenome:MGI:101906
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ly49b; Klra30
    Summary
    The gene is a member of the large lectin-like type 2 transmembrane receptor family of the natural killer gene complex. The gene is located distantly telomeric to its family's gene cluster on chromosome 6. The gene differs from the other genes in its cluster as its promoter region contains long and short interspersed repetitive elements suggesting a possible rearrangement or gene conversion. It is unknown whether this gene's encoded protein is involved with natural killer cell differentiation as are its other family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Klra2 in Genome Data Viewer
    Location:
    6 F3; 6 63.44 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (131196190..131224679, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (131198970..131247716, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 239-like Neighboring gene predicted gene, 57775 Neighboring gene STARR-seq mESC enhancer starr_17492 Neighboring gene predicted gene 5582 Neighboring gene STARR-positive B cell enhancer ABC_E9280 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:131243245-131243354 Neighboring gene mago homolog B, exon junction complex core component

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ly49B is expressed on multiple subpopulations of myeloid cells. Gays F, et al. J Immunol, 2006 Nov 1. PMID 17056508
    2. Mutagenesis of Ly49B reveals key structural elements required for promiscuous binding to MHC class I molecules and new insights into the molecular evolution of Ly49s. Mickiewicz KM, et al. J Immunol, 2014 Feb 15. PMID 24403531
    3. Orderly and nonstochastic acquisition of CD94/NKG2 receptors by developing NK cells derived from embryonic stem cells in vitro. Lian RH, et al. J Immunol, 2002 May 15. PMID 11994449
    4. Comparative analysis of the promoter regions and transcriptional start sites of mouse Ly49 genes. Wilhelm BT, et al. Immunogenetics, 2001 Apr. PMID 11398966
    5. Interactions of Ly49 family receptors with MHC class I ligands in trans and cis. Scarpellino L, et al. J Immunol, 2007 Feb 1. PMID 17237373

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. BALB/c, but not the C57, isoform of Ly49B displays promiscuous MHC class I binding.
      Title: Mutagenesis of Ly49B reveals key structural elements required for promiscuous binding to MHC class I molecules and new insights into the molecular evolution of Ly49s.
    2. Ly49B is expressed at low levels on approximately 1.5% of spleen cells, none which are NK cells or T cells but which instead belong to several distinct subpopulations of myeloid cells.
      Title: Ly49B is expressed on multiple subpopulations of myeloid cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    killer cell lectin-like receptor 2
    Names
    NK cell inhibitory receptor Klra2
    T-cell surface glycoprotein Ly-49B
    T-cell surface glycoprotein Ly49b
    killer cell lectin-like receptor subfamily A member 30
    ly-49b
    lymphocyte antigen 49b
    membrane protein Ly49b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170851.2 → NP_001164322.1  killer cell lectin-like receptor 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC148326, AC163356
      Consensus CDS
      CCDS51929.1
      UniProtKB/TrEMBL
      A0FK58, E9Q433
      Related
      ENSMUSP00000086252.7, ENSMUST00000088867.7
      Conserved Domains (2) summary
      cd03593
      Location:146 → 294
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
      pfam08391
      Location:40 → 159
      Ly49; Ly49-like protein, N-terminal region

    2. NM_008462.6 → NP_032488.4  killer cell lectin-like receptor 2 isoform 2

      See identical proteins and their annotated locations for NP_032488.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
      Source sequence(s)
      AC148326, AC163356
      Consensus CDS
      CCDS20603.1
      UniProtKB/TrEMBL
      Q6P263, Q9D3R1, Q9JHG5
      Related
      ENSMUSP00000032306.9, ENSMUST00000032306.15
      Conserved Domains (2) summary
      cd03593
      Location:146 → 261
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
      pfam08391
      Location:40 → 159
      Ly49; Ly49-like protein, N-terminal region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      131196190..131224679 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165887.1 → XP_036021780.1  killer cell lectin-like receptor 2 isoform X4

      Conserved Domains (2) summary
      cd03593
      Location:55 → 203
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
      pfam08391
      Location:1 → 68
      Ly49; Ly49-like protein, N-terminal region

    2. XM_017321416.2 → XP_017176905.1  killer cell lectin-like receptor 2 isoform X1

      Conserved Domains (2) summary
      cd03593
      Location:253 → 401
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
      pfam08391
      Location:147 → 266
      Ly49; Ly49-like protein, N-terminal region

    3. XM_017321414.2 → XP_017176903.1  killer cell lectin-like receptor 2 isoform X2

      Conserved Domains (2) summary
      cd03593
      Location:253 → 368
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
      pfam08391
      Location:147 → 266
      Ly49; Ly49-like protein, N-terminal region

    4. XM_017321415.2 → XP_017176904.1  killer cell lectin-like receptor 2 isoform X3

      Conserved Domains (1) summary
      pfam08391
      Location:147 → 248
      Ly49; Ly49-like protein, N-terminal region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q60660.1 GenPept UniProtKB/Swiss-Prot:Q60660

    Gene LinkOut

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