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    C4b complement C4B (Chido blood group) [ Mus musculus (house mouse) ]

    Gene ID: 12268, updated on 27-Nov-2024

    Summary

    Official Symbol
    C4bprovided by MGI
    Official Full Name
    complement C4B (Chido blood group)provided by MGI
    Primary source
    MGI:MGI:88228
    See related
    Ensembl:ENSMUSG00000073418 AllianceGenome:MGI:88228
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C4; Ss
    Summary
    Predicted to enable carbohydrate binding activity and complement component C1q complex binding activity. Acts upstream of or within complement activation and immunoglobulin mediated immune response. Located in extracellular space. Is expressed in several structures, including hemolymphoid system; liver; reproductive system; retina; and yolk sac. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in autistic disorder; autoimmune disease (multiple); complement deficiency (multiple); and renal cell carcinoma. Orthologous to several human genes including C4A (complement C4A (Chido/Rodgers blood group)) and C4B (complement C4B (Chido/Rodgers blood group)). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver adult (RPKM 237.2), subcutaneous fat pad adult (RPKM 85.1) and 9 other tissues See more
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    Genomic context

    See C4b in Genome Data Viewer
    Location:
    17 B1; 17 18.29 cM
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34947249..34962876, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34728139..34743902, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene tenascin XB Neighboring gene predicted gene, 24389 Neighboring gene STARR-seq mESC enhancer starr_42436 Neighboring gene cytochrome P450, family 21, subfamily a, polypeptide 2 pseudogene Neighboring gene serine/threonine kinase 19, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_42437 Neighboring gene STARR-seq mESC enhancer starr_42438 Neighboring gene superkiller viralicidic activity 2-like (S. cerevisiae), pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables complement binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables complement component C1q complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in complement activation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within complement activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in complement activation, classical pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within immunoglobulin mediated immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in symbiont cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    complement C4-B
    Names
    complement component 4 (within H-2S)
    complement component 4B (Chido blood group)
    complement component 4B (Childo blood group)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009780.2NP_033910.2  complement C4-B precursor

      See identical proteins and their annotated locations for NP_033910.2

      Status: VALIDATED

      Source sequence(s)
      AK128974, AK157954, AK158256, AK158475, BC067394, BY785731, CA459454, K02798
      Consensus CDS
      CCDS28657.1
      UniProtKB/Swiss-Prot
      E9QKK7, O70346, P01029, Q31201, Q3TYY1, Q3TZC9, Q61372, Q61859, Q62353, Q6NWV8
      UniProtKB/TrEMBL
      B2RWX2
      Related
      ENSMUSP00000069418.9, ENSMUST00000069507.9
      Conserved Domains (8) summary
      cd00017
      Location:686752
      ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
      cd02896
      Location:9921311
      complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...
      pfam00207
      Location:780867
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:139231
      A2M_N; MG2 domain
      pfam07677
      Location:14751564
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:10471313
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:475608
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      cl02512
      Location:15821736
      NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      34947249..34962876 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523532.5XP_006523595.1  complement C4-B isoform X2

      UniProtKB/TrEMBL
      B2RWX2
      Conserved Domains (8) summary
      cd00017
      Location:686752
      ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
      pfam00207
      Location:780867
      A2M; Alpha-2-macroglobulin family
      pfam07677
      Location:14551544
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:9781311
      A2M_comp; A-macroglobulin complement component
      pfam17791
      Location:233318
      MG3; Macroglobulin domain MG3
      pfam01835
      Location:139231
      A2M_N; MG2 domain
      pfam07703
      Location:470609
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      cl02512
      Location:15621716
      NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
    2. XM_006523531.5XP_006523594.1  complement C4-B isoform X1

      UniProtKB/TrEMBL
      B2RWX2
      Conserved Domains (8) summary
      cd00017
      Location:686752
      ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
      pfam00207
      Location:780867
      A2M; Alpha-2-macroglobulin family
      pfam07677
      Location:14751564
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:9781311
      A2M_comp; A-macroglobulin complement component
      pfam17791
      Location:233318
      MG3; Macroglobulin domain MG3
      pfam01835
      Location:139231
      A2M_N; MG2 domain
      pfam07703
      Location:470609
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      cl02512
      Location:15821736
      NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
    3. XM_030249459.1XP_030105319.1  complement C4-B isoform X3

      UniProtKB/TrEMBL
      B2RWX2
      Conserved Domains (8) summary
      cd00017
      Location:686752
      ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
      pfam00207
      Location:780867
      A2M; Alpha-2-macroglobulin family
      pfam07677
      Location:14551544
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:9781311
      A2M_comp; A-macroglobulin complement component
      pfam17791
      Location:233318
      MG3; Macroglobulin domain MG3
      pfam01835
      Location:139231
      A2M_N; MG2 domain
      pfam07703
      Location:470609
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      cl02512
      Location:15621716
      NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...