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    Scd4 stearoyl-coenzyme A desaturase 4 [ Mus musculus (house mouse) ]

    Gene ID: 329065, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Scd4provided by MGI
    Official Full Name
    stearoyl-coenzyme A desaturase 4provided by MGI
    Primary source
    MGI:MGI:2670997
    See related
    Ensembl:ENSMUSG00000050195 AllianceGenome:MGI:2670997
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ACOD4
    Summary
    Enables palmitoyl-CoA 9-desaturase activity and stearoyl-CoA 9-desaturase activity. Involved in cellular response to nutrient and monounsaturated fatty acid biosynthetic process. Acts upstream of or within fatty acid biosynthetic process. Located in membrane. Orthologous to human SCD (stearoyl-CoA desaturase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in mammary gland adult (RPKM 44.2), subcutaneous fat pad adult (RPKM 43.9) and 9 other tissues See more
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    Genomic context

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    See Scd4 in Genome Data Viewer
    Location:
    19 C3; 19 37.98 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (44321765..44335182)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (44333326..44346743)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 54046 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:44358612-44358721 Neighboring gene STARR-positive B cell enhancer ABC_E4283 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:44368225-44368334 Neighboring gene STARR-positive B cell enhancer ABC_E2528 Neighboring gene predicted gene, 41853 Neighboring gene stearoyl-Coenzyme A desaturase 2 Neighboring gene microRNA 5114 Neighboring gene STARR-seq mESC enhancer starr_46229 Neighboring gene STARR-seq mESC enhancer starr_46230 Neighboring gene STARR-positive B cell enhancer ABC_E4284 Neighboring gene STARR-positive B cell enhancer ABC_E972 Neighboring gene STARR-positive B cell enhancer ABC_E7663 Neighboring gene STARR-seq mESC enhancer starr_46234 Neighboring gene stearoyl-Coenzyme A desaturase 1 Neighboring gene STARR-positive B cell enhancer mm9_chr19:44531852-44532152 Neighboring gene predicted gene, 35406

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Stearoyl-CoA Desaturase Regulates Angiogenesis and Energy Metabolism in Ischemic Cardiomyocytes. Gan AM, et al. Int J Mol Sci, 2022 Sep 9. PMID 36142371, Free PMC Article
    2. Syndecan 4 interacts genetically with Vangl2 to regulate neural tube closure and planar cell polarity. Escobedo N, et al. Development, 2013 Jul. PMID 23760952, Free PMC Article
    3. Identification of mouse palmitoyl-coenzyme A Delta9-desaturase. Miyazaki M, et al. J Lipid Res, 2006 Apr. PMID 16443825
    4. Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors. Miyazaki M, et al. J Biol Chem, 2003 Sep 5. PMID 12815040
    5. γ-Linolenic acid in maternal milk drives cardiac metabolic maturation. Paredes A, et al. Nature, 2023 Jun. PMID 37225978

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Stearoyl-CoA Desaturase Regulates Angiogenesis and Energy Metabolism in Ischemic Cardiomyocytes.
      Title: Stearoyl-CoA Desaturase Regulates Angiogenesis and Energy Metabolism in Ischemic Cardiomyocytes.
    2. Results show that mouse stearoyl-coenzyme A desaturase (SCD)1, 2, and 4 desaturate both C18:0 and C16:0, whereas mouse SCD3 uses C16:0 but not C18:0.
      Title: Identification of mouse palmitoyl-coenzyme A Delta9-desaturase.
    3. SCD4 demonstrates tissue-specific regulation by leptin and dietary factors.
      Title: Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC48154

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables iron ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables iron ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables palmitoyl-CoA 9-desaturase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables palmitoyl-CoA 9-desaturase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables palmitoyl-CoA 9-desaturase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables stearoyl-CoA 9-desaturase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables stearoyl-CoA 9-desaturase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables stearoyl-CoA 9-desaturase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables stearoyl-CoA 9-desaturase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to nutrient IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within fatty acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monounsaturated fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within monounsaturated fatty acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monounsaturated fatty acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in unsaturated fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in unsaturated fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    stearoyl-CoA desaturase 4
    Names
    acyl-CoA desaturase 4
    delta(9)-desaturase 4
    fatty acid desaturase 4
    NP_899039.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183216.3 → NP_899039.2  stearoyl-CoA desaturase 4

      See identical proteins and their annotated locations for NP_899039.2

      Status: VALIDATED

      Source sequence(s)
      AC123853
      Consensus CDS
      CCDS29849.1
      UniProtKB/Swiss-Prot
      B9EIY5, Q6T707
      Related
      ENSMUSP00000059860.9, ENSMUST00000058856.9
      Conserved Domains (2) summary
      cd03505
      Location:94 → 331
      Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...
      pfam00487
      Location:94 → 300
      FA_desaturase; Fatty acid desaturase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      44321765..44335182
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6T707.1 GenPept UniProtKB/Swiss-Prot:Q6T707

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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