FBXO6 F-box protein 6 [Homo sapiens (human)] - Gene

Summary

Official Symbol: FBXO6provided by HGNC
Official Full Name: F-box protein 6provided by HGNC
Primary source: HGNC:HGNC:13585
See related: Ensembl:ENSG00000116663 MIM:605647; AllianceGenome:HGNC:13585
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FBG2; FBS2; FBX6; Fbx6b
Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class, and its C-terminal region is highly similar to that of rat NFB42 (neural F Box 42 kDa) which may be involved in the control of the cell cycle. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in lymph node (RPKM 5.5), appendix (RPKM 4.6) and 25 other tissues See more
Orthologs: all
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Genomic context

Location:: 1p36.22

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (11664200..11674354)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (11208255..11218422)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (11724257..11734411)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structural basis of sugar recognition by SCF[FBS2] ubiquitin ligase involved in NGLY1 deficiency.
Title: Structural basis of sugar recognition by SCF(FBS2) ubiquitin ligase involved in NGLY1 deficiency.
The USP18-FBXO6 axis maintains the malignancy of ovarian cancer.
Title: The USP18-FBXO6 axis maintains the malignancy of ovarian cancer.
FBXO6-mediated RNASET2 ubiquitination and degradation governs the development of ovarian cancer.
Title: FBXO6-mediated RNASET2 ubiquitination and degradation governs the development of ovarian cancer.
Fbxo6 confers drug-sensitization to cisplatin via inhibiting the activation of Chk1 in non-small cell lung cancer
Title: Fbxo6 confers drug-sensitization to cisplatin via inhibiting the activation of Chk1 in non-small cell lung cancer.
our studies have identified a general but, to our knowledge, previously unrecognized role and a novel noncanonical mechanism of FBXO6 in modulating IFN-I-mediated antiviral immune responses
Title: Noncanonical Role of FBXO6 in Regulating Antiviral Immunity.
Fbxo6 is a novel regulator of mitosis by controlling chromosome separation via interacting with the spindle checkpoint proteins Mad2 and BubR1.
Title: Overexpression of Fbxo6 inactivates spindle checkpoint by interacting with Mad2 and BubR1.
FBXO6 as a functional E3 ubiquitin ligase for Ero1L that plays a critical role in inhibiting endoplasmic reticulum stress-induced apoptosis.
Title: FBXO6-Mediated Ubiquitination and Degradation of Ero1L Inhibits Endoplasmic Reticulum Stress-Induced Apoptosis.
It might inhibit cadmium-induced ER stress by functioning as a ubiquitin ligase in the ERAD system, thereby attenuating the cell death induced by subsequent JNK1 activation.
Title: FBXO6 attenuates cadmium toxicity in HEK293 cells by inhibiting ER stress and JNK activation.
systematical identification of the FBXO6-interacting glycoproteins, critical for clarifying its substrates as well as biological functions.
Title: Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.
Two interacting proteins of human FBXO6 protein have been found using the service in the study.
Title: SPPS: a sequence-based method for predicting probability of protein-protein interaction partners.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope transmembrane glycoprotein gp41	env	HIV-1 gp41 is identified to have a physical interaction with F-box protein 6 (FBXO6) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

D1S1742E (e-PCR)
- UniSTS:150319

PMC156606P1 (e-PCR)
- UniSTS:271408

PMC156606P2 (e-PCR)
- UniSTS:271409

PMC156606P3 (e-PCR)
- UniSTS:271410

sY3084 (e-PCR)
- UniSTS:515126

IB3322 (e-PCR)
- UniSTS:10565

WI-15845 (e-PCR)
- UniSTS:41035

L18426 (e-PCR)
- UniSTS:34648

Bdy91f02 (e-PCR)
- UniSTS:27022

IB1204 (e-PCR)
- UniSTS:61113

RH80622 (e-PCR)
- UniSTS:87274

FBXO6_1418 (e-PCR)
- UniSTS:277233

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	ISS Inferred from Sequence or Structural Similarity more info
contributes_to ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA damage checkpoint signaling	TAS Traceable Author Statement more info	PubMed
involved_in DNA repair	TAS Traceable Author Statement more info	PubMed
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ERAD pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glycoprotein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	TAS Traceable Author Statement more info	PubMed
involved_in response to unfolded protein	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SCF ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
is_active_in endoplasmic reticulum quality control compartment	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: F-box only protein 6

Names: F-box protein FBG2; F-box protein Fbx6; F-box protein that recognizes sugar chains 2; F-box/G-domain protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_018438.6 → NP_060908.1 F-box only protein 6

See identical proteins and their annotated locations for NP_060908.1

Status: REVIEWED

Source sequence(s)

AF129536, AK314989, BC020880

Consensus CDS

CCDS133.1

UniProtKB/Swiss-Prot

B1AK42, B2RC88, Q9NRD1, Q9UKT3

UniProtKB/TrEMBL

J3KQ72

Related

ENSP00000365944.4, ENST00000376753.9

Conserved Domains (2) summary

pfam04300
Location:79 → 257

FBA; F-box associated region

pfam12937
Location:13 → 58

F-box-like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

11664200..11674354

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005263448.6 → XP_005263505.1 F-box only protein 6 isoform X1

See identical proteins and their annotated locations for XP_005263505.1

UniProtKB/Swiss-Prot

B1AK42, B2RC88, Q9NRD1, Q9UKT3

UniProtKB/TrEMBL

J3KQ72

Conserved Domains (2) summary

pfam04300
Location:79 → 257

FBA; F-box associated region

pfam12937
Location:13 → 58

F-box-like
XM_005263451.6 → XP_005263508.1 F-box only protein 6 isoform X1

See identical proteins and their annotated locations for XP_005263508.1

UniProtKB/Swiss-Prot

B1AK42, B2RC88, Q9NRD1, Q9UKT3

UniProtKB/TrEMBL

J3KQ72

Conserved Domains (2) summary

pfam04300
Location:79 → 257

FBA; F-box associated region

pfam12937
Location:13 → 58

F-box-like
XM_005263449.6 → XP_005263506.1 F-box only protein 6 isoform X1

See identical proteins and their annotated locations for XP_005263506.1

UniProtKB/Swiss-Prot

B1AK42, B2RC88, Q9NRD1, Q9UKT3

UniProtKB/TrEMBL

J3KQ72

Related

ENSP00000388781.1, ENST00000449067.1

Conserved Domains (2) summary

pfam04300
Location:79 → 257

FBA; F-box associated region

pfam12937
Location:13 → 58

F-box-like
XM_011541232.4 → XP_011539534.1 F-box only protein 6 isoform X1

See identical proteins and their annotated locations for XP_011539534.1

UniProtKB/Swiss-Prot

B1AK42, B2RC88, Q9NRD1, Q9UKT3

UniProtKB/TrEMBL

J3KQ72

Conserved Domains (2) summary

pfam04300
Location:79 → 257

FBA; F-box associated region

pfam12937
Location:13 → 58

F-box-like

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

11208255..11218422

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054335955.1 → XP_054191930.1 F-box only protein 6 isoform X1

UniProtKB/Swiss-Prot

B1AK42, B2RC88, Q9NRD1, Q9UKT3

UniProtKB/TrEMBL

J3KQ72
XM_054335954.1 → XP_054191929.1 F-box only protein 6 isoform X1

UniProtKB/Swiss-Prot

B1AK42, B2RC88, Q9NRD1, Q9UKT3

UniProtKB/TrEMBL

J3KQ72
XM_054335957.1 → XP_054191932.1 F-box only protein 6 isoform X1

UniProtKB/Swiss-Prot

B1AK42, B2RC88, Q9NRD1, Q9UKT3

UniProtKB/TrEMBL

J3KQ72
XM_054335956.1 → XP_054191931.1 F-box only protein 6 isoform X1

UniProtKB/Swiss-Prot

B1AK42, B2RC88, Q9NRD1, Q9UKT3

UniProtKB/TrEMBL

J3KQ72