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    Opcml opioid binding protein/cell adhesion molecule-like [ Mus musculus (house mouse) ]

    Gene ID: 330908, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Opcmlprovided by MGI
    Official Full Name
    opioid binding protein/cell adhesion molecule-likeprovided by MGI
    Primary source
    MGI:MGI:97397
    See related
    Ensembl:ENSMUSG00000062257 AllianceGenome:MGI:97397
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm181; Obcam; 3732419F12; C230027C17; 2900075O15Rik; B930023M13Rik
    Summary
    Is expressed in central nervous system; dorsal root ganglion; nose; tongue; and trigeminal nerve. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to human OPCML (opioid binding protein/cell adhesion molecule like). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in frontal lobe adult (RPKM 13.6), cortex adult (RPKM 13.0) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Opcml in Genome Data Viewer
    Location:
    9 A4; 9 13.73 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (27702050..28836706)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (27790716..28925410)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_23627 Neighboring gene STARR-seq mESC enhancer starr_23628 Neighboring gene N(alpha)-acetyltransferase 20, NatB catalytic subunit pseudogene Neighboring gene STARR-seq mESC enhancer starr_23629 Neighboring gene voltage-dependent anion channel 1 pseudogene Neighboring gene predicted gene, 39314 Neighboring gene STARR-seq mESC enhancer starr_23630 Neighboring gene STARR-seq mESC enhancer starr_23631 Neighboring gene STARR-seq mESC enhancer starr_23632 Neighboring gene STARR-seq mESC enhancer starr_23633 Neighboring gene predicted gene, 53502 Neighboring gene predicted gene, 33456 Neighboring gene STARR-seq mESC enhancer starr_23635 Neighboring gene predicted gene, 39313 Neighboring gene STARR-seq mESC enhancer starr_23636 Neighboring gene STARR-seq mESC enhancer starr_23637 Neighboring gene STARR-seq mESC enhancer starr_23639 Neighboring gene STARR-seq mESC enhancer starr_23640 Neighboring gene STARR-seq mESC enhancer starr_23641 Neighboring gene STARR-seq mESC enhancer starr_23644 Neighboring gene STARR-seq mESC enhancer starr_23645 Neighboring gene STARR-seq mESC enhancer starr_23646 Neighboring gene STARR-seq mESC enhancer starr_23647 Neighboring gene predicted gene 15520 Neighboring gene neurotrimin Neighboring gene STARR-seq mESC enhancer starr_23648 Neighboring gene STARR-seq mESC enhancer starr_23649 Neighboring gene STARR-seq mESC enhancer starr_23651 Neighboring gene STARR-seq mESC enhancer starr_23652 Neighboring gene STARR-seq mESC enhancer starr_23653 Neighboring gene STARR-seq mESC enhancer starr_23654 Neighboring gene predicted gene 15521

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression of ovarian tumour suppressor OPCML in the female CD-1 mouse reproductive tract. Fleming JS, et al. Reproduction, 2009 Apr. PMID 19176311, Free PMC Article
    2. Genetic mapping of opioid binding protein gene(s) to mouse chromosome 9. Chakraborti A, et al. Mamm Genome, 1993. PMID 8439730
    3. Gene-targeted deletion of OPCML and Neurotrimin in mice does not yield congenital heart defects. Ye M, et al. Am J Med Genet A, 2014 Apr. PMID 24616287
    4. Spatiotemporal expression of IgLON family members in the developing mouse nervous system. Fearnley S, et al. Sci Rep, 2021 Oct 1. PMID 34599206, Free PMC Article
    5. Isolation, characterization, and chromosomal location of the mouse enamelysin gene. Caterina J, et al. Genomics, 1999 Dec 1. PMID 10610728

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC99974

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    opioid-binding protein/cell adhesion molecule

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177906.5 → NP_808574.2  opioid-binding protein/cell adhesion molecule precursor

      Status: VALIDATED

      Source sequence(s)
      AC102567, AC116523, AC154803, AC166352
      Consensus CDS
      CCDS22942.1
      UniProtKB/TrEMBL
      Q3TYL3, Q6DFY2
      Related
      ENSMUSP00000110898.3, ENSMUST00000115243.9
      Conserved Domains (4) summary
      smart00408
      Location:142 → 198
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:226 → 304
      IG_like; Immunoglobulin like
      pfam00047
      Location:219 → 303
      ig; Immunoglobulin domain
      cl11960
      Location:37 → 125
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      27702050..28836706
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155074.1 → XP_036010967.1  opioid-binding protein/cell adhesion molecule isoform X9

      UniProtKB/TrEMBL
      Q3TYL3
      Conserved Domains (3) summary
      pfam13927
      Location:181 → 258
      Ig_3; Immunoglobulin domain
      cd00096
      Location:182 → 188
      Ig; putative Ig strand A [structural motif]
      cl11960
      Location:3 → 91
      Ig; Immunoglobulin domain

    2. XM_036155073.1 → XP_036010966.1  opioid-binding protein/cell adhesion molecule isoform X7

      UniProtKB/TrEMBL
      Q3TYL3
      Conserved Domains (3) summary
      pfam13927
      Location:216 → 293
      Ig_3; Immunoglobulin domain
      cd00096
      Location:217 → 223
      Ig; putative Ig strand A [structural motif]
      cl11960
      Location:37 → 125
      Ig; Immunoglobulin domain

    3. XM_036155078.1 → XP_036010971.1  opioid-binding protein/cell adhesion molecule isoform X12

      Conserved Domains (3) summary
      smart00409
      Location:2 → 32
      IG; Immunoglobulin
      pfam13927
      Location:122 → 199
      Ig_3; Immunoglobulin domain
      cd00096
      Location:123 → 129
      Ig; putative Ig strand A [structural motif]

    4. XM_036155077.1 → XP_036010970.1  opioid-binding protein/cell adhesion molecule isoform X11

      Conserved Domains (3) summary
      smart00409
      Location:2 → 32
      IG; Immunoglobulin
      pfam13927
      Location:123 → 200
      Ig_3; Immunoglobulin domain
      cd00096
      Location:124 → 130
      Ig; putative Ig strand A [structural motif]

    5. XM_036155072.1 → XP_036010965.1  opioid-binding protein/cell adhesion molecule isoform X4

      UniProtKB/TrEMBL
      Q3TYL3
      Conserved Domains (3) summary
      pfam13927
      Location:215 → 292
      Ig_3; Immunoglobulin domain
      cd00096
      Location:216 → 222
      Ig; putative Ig strand A [structural motif]
      cl11960
      Location:37 → 125
      Ig; Immunoglobulin domain

    6. XM_030244423.2 → XP_030100283.1  opioid-binding protein/cell adhesion molecule isoform X3

      UniProtKB/TrEMBL
      Q3TYL3
      Conserved Domains (3) summary
      pfam13927
      Location:216 → 293
      Ig_3; Immunoglobulin domain
      cd00096
      Location:217 → 223
      Ig; putative Ig strand A [structural motif]
      cl11960
      Location:37 → 125
      Ig; Immunoglobulin domain

    7. XM_036155076.1 → XP_036010969.1  opioid-binding protein/cell adhesion molecule isoform X10

      Conserved Domains (3) summary
      smart00409
      Location:2 → 32
      IG; Immunoglobulin
      pfam13927
      Location:123 → 200
      Ig_3; Immunoglobulin domain
      cd00096
      Location:124 → 130
      Ig; putative Ig strand A [structural motif]

    8. XM_006510439.5 → XP_006510502.1  opioid-binding protein/cell adhesion molecule isoform X8

      UniProtKB/TrEMBL
      Q3TYL3
      Conserved Domains (3) summary
      pfam13927
      Location:182 → 259
      Ig_3; Immunoglobulin domain
      cd00096
      Location:183 → 189
      Ig; putative Ig strand A [structural motif]
      cl11960
      Location:3 → 91
      Ig; Immunoglobulin domain

    9. XM_006510435.5 → XP_006510498.1  opioid-binding protein/cell adhesion molecule isoform X2

      UniProtKB/TrEMBL
      Q3TYL3
      Conserved Domains (3) summary
      pfam13927
      Location:222 → 299
      Ig_3; Immunoglobulin domain
      cd00096
      Location:223 → 229
      Ig; putative Ig strand A [structural motif]
      cl11960
      Location:44 → 132
      Ig; Immunoglobulin domain

    10. XM_006510434.5 → XP_006510497.1  opioid-binding protein/cell adhesion molecule isoform X1

      UniProtKB/TrEMBL
      Q3TYL3
      Conserved Domains (3) summary
      pfam13927
      Location:223 → 300
      Ig_3; Immunoglobulin domain
      cd00096
      Location:224 → 230
      Ig; putative Ig strand A [structural motif]
      cl11960
      Location:44 → 132
      Ig; Immunoglobulin domain

    11. XM_036155075.1 → XP_036010968.1  opioid-binding protein/cell adhesion molecule isoform X9

      UniProtKB/TrEMBL
      Q3TYL3
      Conserved Domains (3) summary
      pfam13927
      Location:181 → 258
      Ig_3; Immunoglobulin domain
      cd00096
      Location:182 → 188
      Ig; putative Ig strand A [structural motif]
      cl11960
      Location:3 → 91
      Ig; Immunoglobulin domain

    12. XM_006510438.5 → XP_006510501.1  opioid-binding protein/cell adhesion molecule isoform X6

      UniProtKB/TrEMBL
      Q3TYL3
      Conserved Domains (3) summary
      pfam13927
      Location:222 → 299
      Ig_3; Immunoglobulin domain
      cd00096
      Location:223 → 229
      Ig; putative Ig strand A [structural motif]
      cl11960
      Location:44 → 132
      Ig; Immunoglobulin domain

    13. XM_006510437.5 → XP_006510500.1  opioid-binding protein/cell adhesion molecule isoform X5

      UniProtKB/TrEMBL
      G5E8G3, Q3TYL3
      Related
      ENSMUSP00000073493.6, ENSMUST00000073822.6
      Conserved Domains (3) summary
      pfam13927
      Location:223 → 300
      Ig_3; Immunoglobulin domain
      cd00096
      Location:224 → 230
      Ig; putative Ig strand A [structural motif]
      cl11960
      Location:44 → 132
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version

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