Prps1l1 phosphoribosyl pyrophosphate synthetase 1-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prps1l1provided by MGI
Official Full Name: phosphoribosyl pyrophosphate synthetase 1-like 1provided by MGI
Primary source: MGI:MGI:1922706
See related: Ensembl:ENSMUSG00000092305 AllianceGenome:MGI:1922706
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1700011K15Rik
Summary: Predicted to enable ribose phosphate diphosphokinase activity. Predicted to be involved in 5-phosphoribose 1-diphosphate biosynthetic process and purine nucleotide biosynthetic process. Predicted to be part of ribose phosphate diphosphokinase complex. Predicted to be active in cytoplasm. Is expressed in cerebral cortex; heart; and liver. Orthologous to human PRPS1L1 (phosphoribosyl pyrophosphate synthetase 1 like 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human all
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Genomic context

Location:: 12 A3; 12 15.64 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (35034760..35036435)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (34984761..34986436)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Prps1l1, a testis-specific gene, is dispensable for mouse spermatogenesis.
Title: Prps1l1, a testis-specific gene, is dispensable for mouse spermatogenesis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ribose phosphate diphosphokinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in 5-phosphoribose 1-diphosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in purine nucleotide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of ribose phosphate diphosphokinase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ribose-phosphate pyrophosphokinase 3

NP_083570.1

EC 2.7.6.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029294.2 → NP_083570.1 ribose-phosphate pyrophosphokinase 3

See identical proteins and their annotated locations for NP_083570.1

Status: VALIDATED

Source sequence(s)

AK077203

Consensus CDS

CCDS56836.1

UniProtKB/TrEMBL

Q3TI27, Q3UPD5, Q8C5R8

Related

ENSMUSP00000133931.2, ENSMUST00000134550.3

Conserved Domains (3) summary

COG0462
Location:1 → 313

PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]

pfam13793
Location:4 → 120

Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase

cl00309
Location:161 → 313

PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain