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    MRPL12 mitochondrial ribosomal protein L12 [ Homo sapiens (human) ]

    Gene ID: 6182, updated on 10-Dec-2024

    Summary

    Official Symbol
    MRPL12provided by HGNC
    Official Full Name
    mitochondrial ribosomal protein L12provided by HGNC
    Primary source
    HGNC:HGNC:10378
    See related
    Ensembl:ENSG00000262814 MIM:602375; AllianceGenome:HGNC:10378
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    5c5-2; L12mt; MRPL7; bL12m; RPML12; MRPL7/L12; MRP-L31/34
    Summary
    Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which forms homodimers. In prokaryotic ribosomes, two L7/L12 dimers and one L10 protein form the L8 protein complex. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in colon (RPKM 31.4), heart (RPKM 25.0) and 25 other tissues See more
    Orthologs
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    Genomic context

    See MRPL12 in Genome Data Viewer
    Location:
    17q25.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (81703367..81707517)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (82620267..82624415)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79670397..79674547)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12976 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9143 Neighboring gene Sharpr-MPRA regulatory region 13823 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9145 Neighboring gene ARF like GTPase 16 Neighboring gene hepatocyte growth factor-regulated tyrosine kinase substrate Neighboring gene ReSE screen-validated silencer GRCh37_chr17:79659706-79659891 Neighboring gene microRNA 6786 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79667464-79668068 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79668069-79668672 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79669277-79669880 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79669881-79670484 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9147 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79677211-79677911 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12978 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9148 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9149 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9150 Neighboring gene solute carrier family 25 member 10 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79689497-79690038 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:79697182-79697401 Neighboring gene uncharacterized LOC105371929 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79699122-79699658

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC8610, FLJ60124

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding PubMed 
    enables mRNA binding  
    enables protein binding PubMed 
    enables structural constituent of ribosome  

    General protein information

    Preferred Names
    large ribosomal subunit protein bL12m
    Names
    39S ribosomal protein L12, mitochondrial
    MRP-L12
    mitochondrial large ribosomal subunit protein bL12m

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002949.4 → NP_002940.2  large ribosomal subunit protein bL12m

      See identical proteins and their annotated locations for NP_002940.2

      Status: REVIEWED

      Source sequence(s)
      AC139530, AF105278, BC002344, DA648796
      Consensus CDS
      CCDS11785.1
      UniProtKB/Swiss-Prot
      P52815, Q969U0, Q9HCA2, Q9UQJ3
      Related
      ENSP00000333837.3, ENST00000333676.8
      Conserved Domains (2) summary
      pfam00542
      Location:130 → 198
      Ribosomal_L12; Ribosomal protein L7/L12 C-terminal domain
      pfam16320
      Location:63 → 102
      Ribosomal_L12_N; Ribosomal protein L7/L12 dimerization domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      81703367..81707517
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      82620267..82624415
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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