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    UBE2QL1 ubiquitin conjugating enzyme E2 QL1 [ Homo sapiens (human) ]

    Gene ID: 134111, updated on 10-Dec-2024

    Summary

    Official Symbol
    UBE2QL1provided by HGNC
    Official Full Name
    ubiquitin conjugating enzyme E2 QL1provided by HGNC
    Primary source
    HGNC:HGNC:37269
    See related
    Ensembl:ENSG00000215218 MIM:615832; AllianceGenome:HGNC:37269
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables ubiquitin conjugating enzyme activity. Predicted to be involved in protein polyubiquitination. Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in brain (RPKM 12.4), heart (RPKM 3.3) and 7 other tissues See more
    Orthologs
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    Genomic context

    See UBE2QL1 in Genome Data Viewer
    Location:
    5p15.31
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (6448859..6496723)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (6379225..6427083)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (6448972..6496836)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22329 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22330 Neighboring gene mediator complex subunit 10 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:6408294-6409493 Neighboring gene uncharacterized LOC124900933 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15896 Neighboring gene uncharacterized LOC105374639 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22331 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22332 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22333 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15897 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22334 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15898 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:6583428-6583589 Neighboring gene long intergenic non-protein coding RNA 1018 Neighboring gene NOP2/Sun RNA methyltransferase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Clone Names

    • FLJ25076, FLJ39293

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding  
    enables protein binding PubMed 
    enables ubiquitin conjugating enzyme activity  
    enables ubiquitin conjugating enzyme activity PubMed 
    Process Evidence Code Pubs
    involved_in protein polyubiquitination  
    Component Evidence Code Pubs
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in plasma membrane  

    General protein information

    Preferred Names
    ubiquitin-conjugating enzyme E2Q-like protein 1
    Names
    E2Q-like ubiquitin-conjugating enzyme 1
    ubiquitin conjugating enzyme E2 Q family like 1
    ubiquitin-conjugating enzyme E2Q family-like 1
    NP_001138633.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145161.3NP_001138633.1  ubiquitin-conjugating enzyme E2Q-like protein 1

      See identical proteins and their annotated locations for NP_001138633.1

      Status: VALIDATED

      Source sequence(s)
      AC093307, BC127723
      Consensus CDS
      CCDS47189.1
      UniProtKB/Swiss-Prot
      A1L167
      Related
      ENSP00000382713.3, ENST00000399816.4
      Conserved Domains (1) summary
      cl00154
      Location:1115
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      6448859..6496723
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791776.1 Reference GRCh38.p14 PATCHES

      Range
      152669..200533
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      6379225..6427083
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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