STK36 serine/threonine kinase 36 [Homo sapiens (human)] - Gene

Summary

Official Symbol: STK36provided by HGNC
Official Full Name: serine/threonine kinase 36provided by HGNC
Primary source: HGNC:HGNC:17209
See related: Ensembl:ENSG00000163482 MIM:607652; AllianceGenome:HGNC:17209
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FU; CILD46
Summary: This gene encodes a member of the serine/threonine kinase family of enzymes. This family member is similar to a Drosophila protein that plays a key role in the Hedgehog signaling pathway. This human protein is a positive regulator of the GLI zinc-finger transcription factors. Knockout studies of the homologous mouse gene suggest that defects in this human gene may lead to congenital hydrocephalus, possibly due to a functional defect in motile cilia. Because Hedgehog signaling is frequently activated in certain kinds of gastrointestinal cancers, it has been suggested that this gene is a target for the treatment of these cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Expression: Broad expression in testis (RPKM 24.8), gall bladder (RPKM 6.4) and 21 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2q35

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (218672086..218702717)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (219158642..219189274)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (219536809..219567440)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Serine/threonine kinase 36 induced epithelial-mesenchymal transition promotes docetaxel resistance in prostate cancer.
Title: Serine/threonine kinase 36 induced epithelial-mesenchymal transition promotes docetaxel resistance in prostate cancer.
Data identified homozygous loss-of-function mutations in STK36 in one PCD-affected individual with situs solitus. Transmission electron microscopy analysis demonstrates that STK36 is required for cilia orientation in human respiratory epithelial cells, with a probable localization of STK36 between the RS and CP. STK36 screening can now be included for this rare and difficult to diagnose PCD subgroup.
Title: Mutation of serine/threonine protein kinase 36 (STK36) causes primary ciliary dyskinesia with a central pair defect.
Fu ubiquitination and cleavage is one of the key elements connecting the MID1-PP2A protein complex with GLI3 activity control
Title: The E3 ubiquitin ligase MID1 catalyzes ubiquitination and cleavage of Fu.
The FU gene and its genomic structure was identified.
Title: The FU gene and its possible protein isoforms.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Ciliary dyskinesia, primary, 46 MedGen: C5543646 OMIM: 619436 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G27519 (e-PCR)
- UniSTS:2575

WI-22153 (e-PCR)
- UniSTS:57632

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	TAS Traceable Author Statement more info	PubMed
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine/threonine kinase activity	TAS Traceable Author Statement more info	PubMed
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in axoneme assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brain development	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in epithelial cilium movement involved in extracellular fluid movement	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of smoothened signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in post-embryonic development	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein phosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in smoothened signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in smoothened signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: serine/threonine-protein kinase 36

Names: fused homolog; testicular tissue protein Li 188

NP_001230242.1

EC 2.7.11.1

NP_001356352.1

EC 2.7.11.1

NP_056505.2

EC 2.7.11.1

XP_011509261.1

EC 2.7.11.1

XP_016859293.2

EC 2.7.11.1

XP_047299887.1

EC 2.7.11.1

XP_047299888.1

EC 2.7.11.1

XP_054197357.1

EC 2.7.11.1

XP_054197358.1

EC 2.7.11.1

XP_054197359.1

EC 2.7.11.1

XP_054197360.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029739.1 RefSeqGene

Range

5061..35690

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001243313.2 → NP_001230242.1 serine/threonine-protein kinase 36 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (2, also known as L-FUdelta24) that is shorter than isoform 1.

Source sequence(s)

AA524236, AB033104

Consensus CDS

CCDS58750.1

UniProtKB/Swiss-Prot

Q9NRP7

Related

ENSP00000375954.3, ENST00000392105.7

Conserved Domains (2) summary

smart00220
Location:4 → 254

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14002
Location:2 → 254

STKc_STK36; Catalytic domain of Serine/Threonine Kinase 36
NM_001369423.1 → NP_001356352.1 serine/threonine-protein kinase 36 isoform 1

Status: REVIEWED

Source sequence(s)

AC009974

Consensus CDS

CCDS2421.1

UniProtKB/Swiss-Prot

B7WPM3, Q8TC32, Q9H9N9, Q9NRP7, Q9UF35, Q9ULE2

UniProtKB/TrEMBL

A0A140VJW1

Related

ENSP00000394095.1, ENST00000440309.5

Conserved Domains (1) summary

cd14002
Location:2 → 254

STKc_STK36; Catalytic domain of Serine/Threonine Kinase 36
NM_015690.5 → NP_056505.2 serine/threonine-protein kinase 36 isoform 1

See identical proteins and their annotated locations for NP_056505.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1, also known as long form or L-FU).

Source sequence(s)

AA524236, AB033104, AF200815, DB062910

Consensus CDS

CCDS2421.1

UniProtKB/Swiss-Prot

B7WPM3, Q8TC32, Q9H9N9, Q9NRP7, Q9UF35, Q9ULE2

UniProtKB/TrEMBL

A0A140VJW1

Related

ENSP00000295709.3, ENST00000295709.8

Conserved Domains (1) summary

cd14002
Location:2 → 254

STKc_STK36; Catalytic domain of Serine/Threonine Kinase 36

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000002.12 Reference GRCh38.p14 Primary Assembly

Range

218672086..218702717

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011510959.3 → XP_011509261.1 serine/threonine-protein kinase 36 isoform X1

Conserved Domains (2) summary

smart00220
Location:4 → 254

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14002
Location:2 → 254

STKc_STK36; Catalytic domain of Serine/Threonine Kinase 36
XM_047443932.1 → XP_047299888.1 serine/threonine-protein kinase 36 isoform X2
XM_047443931.1 → XP_047299887.1 serine/threonine-protein kinase 36 isoform X1
XM_017003804.3 → XP_016859293.2 serine/threonine-protein kinase 36 isoform X2