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    STATH statherin [ Homo sapiens (human) ]

    Gene ID: 6779, updated on 10-Dec-2024

    Summary

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    Official Symbol
    STATHprovided by HGNC
    Official Full Name
    statherinprovided by HGNC
    Primary source
    HGNC:HGNC:11369
    See related
    Ensembl:ENSG00000126549 MIM:184470; AllianceGenome:HGNC:11369
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    STR
    Summary
    Predicted to enable hydroxyapatite binding activity. Predicted to be involved in ossification. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward salivary gland (RPKM 34203.8) See more
    Orthologs
    all
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    Genomic context

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    See STATH in Genome Data Viewer
    Location:
    4q13.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (69995966..70002570)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (73330761..73337367)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (70861683..70868287)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene casein beta Neighboring gene uncharacterized LOC105377269 Neighboring gene histatin 3 Neighboring gene histatin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A statherin and calcium enriched layer at the air interface of human parotid saliva. Proctor GB, et al. Biochem J, 2005 Jul 1. PMID 15769251, Free PMC Article
    2. Complete covalent structure of statherin, a tyrosine-rich acidic peptide which inhibits calcium phosphate precipitation from human parotid saliva. Schlesinger DH, et al. J Biol Chem, 1977 Mar 10. PMID 838735
    3. Salivary statherin. Dependence on sequence, charge, hydrogen bonding potency, and helical conformation for adsorption to hydroxyapatite and inhibition of mineralization. Raj PA, et al. J Biol Chem, 1992 Mar 25. PMID 1313424
    4. Structure and sequence determination of the gene encoding human salivary statherin. Sabatini LM, et al. Gene, 1990 May 14. PMID 2373369
    5. Tissue distribution of RNAs for cystatins, histatins, statherin, and proline-rich salivary proteins in humans and macaques. Sabatini LM, et al. J Dent Res, 1989 Jul. PMID 2483725

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Statherin and alpha-amylase levels in saliva from patients with gingivitis and periodontitis.
      Title: Statherin and alpha-amylase levels in saliva from patients with gingivitis and periodontitis.
    2. A negative screening of rare genetic variants in the ADIPOQ and STATH genes in cystic fibrosis.
      Title: A negative screening of rare genetic variants in the ADIPOQ and STATH genes in cystic fibrosis.
    3. The total protein and statherin in the in-vivo AEP were different between eroded and non-eroded tooth surfaces of the same patient
      Title: Reduced statherin in acquired enamel pellicle on eroded teeth compared to healthy teeth in the same subjects: An in-vivo study.
    4. effects of statherin on intracellular calcium level and its subsequent related molecular alterations would give us new pathogenic aspect in oral carcinogenesis
      Title: Role of statherin in oral carcinogenesis.
    5. phenylalanine orientations in statherin bound to hydroxyapatite surfaces
      Title: Direct observation of phenylalanine orientations in statherin bound to hydroxyapatite surfaces.
    6. Data show that the full characterization of the statherin peptides generated facilitates the elucidation of their novel functional roles in the oral and gastro-intestinal environment.
      Title: Mass spectrometric identification of key proteolytic cleavage sites in statherin affecting mineral homeostasis and bacterial binding domains.
    7. Observational study of gene-disease association. (HuGE Navigator)
      Title: New genetic associations detected in a host response study to hepatitis B vaccine.
    8. insight into the molecular interactions of statherin with hydroxyapatite surfaces
      Title: A (13)C{(31)P} REDOR NMR investigation of the role of glutamic acid residues in statherin- hydroxyapatite recognition.
    9. In conclusion, statherin induces transition to yeast of Candida albicans hyphae and may thus contribute to the oral defense against candidiasis.
      Title: Identification of salivary components that induce transition of hyphae to yeast in Candida albicans.
    10. inhibits calcium phosphate precipitation
      Title: Comparison of inhibitory activity on calcium phosphate precipitation by acidic proline-rich proteins, statherin, and histatin-1.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif upregulates the expression of statherin (STATH) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: HTN3

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables extracellular matrix constituent, lubricant activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables hydroxyapatite binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of tooth enamel NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biomineral tissue development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response to bacterium IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of bone mineralization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in ossification TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in saliva secretion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    statherin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009181.2 → NP_001009181.1  statherin isoform b precursor

      See identical proteins and their annotated locations for NP_001009181.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform b, which is shorter than isoform a.
      Source sequence(s)
      AC063956, BC067219, CB958641, CB986973
      Consensus CDS
      CCDS33998.1
      UniProtKB/Swiss-Prot
      P02808
      Related
      ENSP00000370448.2, ENST00000381060.2

    2. NM_003154.3 → NP_003145.1  statherin isoform a precursor

      See identical proteins and their annotated locations for NP_003145.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC063956, BC067219, CB958641, CB986973
      Consensus CDS
      CCDS3533.1
      UniProtKB/Swiss-Prot
      A6NKE9, B2R4F8, P02808
      Related
      ENSP00000246895.4, ENST00000246895.9
      Conserved Domains (1) summary
      pfam03875
      Location:20 → 50
      Statherin

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      69995966..70002570
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_013171801.1 Reference GRCh38.p14 PATCHES

      Range
      36102..42706
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      73330761..73337367
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P02808.2 GenPept UniProtKB/Swiss-Prot:P02808

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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