U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    TAFA4 TAFA chemokine like family member 4 [ Homo sapiens (human) ]

    Gene ID: 151647, updated on 10-Dec-2024

    Summary

    Official Symbol
    TAFA4provided by HGNC
    Official Full Name
    TAFA chemokine like family member 4provided by HGNC
    Primary source
    HGNC:HGNC:21591
    See related
    Ensembl:ENSG00000163377 MIM:617498; AllianceGenome:HGNC:21591
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TAFA-4; FAM19A4
    Summary
    This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2011]
    Expression
    Biased expression in adrenal (RPKM 8.7), gall bladder (RPKM 0.7) and 1 other tissue See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TAFA4 in Genome Data Viewer
    Location:
    3p14.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (68731766..68932547, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (68769008..68969284, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (68780917..68981698, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:68693138-68693638 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:68693639-68694139 Neighboring gene ribosomal protein lateral stalk subunit P0 pseudogene 8 Neighboring gene proteasome 26S subunit, ATPase 1 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:68859761-68860260 Neighboring gene RNA, 5S ribosomal pseudogene 135 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:68968097-68968699 Neighboring gene Sharpr-MPRA regulatory region 589 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14514 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14515 Neighboring gene EGF domain specific O-linked N-acetylglucosamine transferase Neighboring gene EOGT divergent transcript Neighboring gene TATA element modulatory factor 1 Neighboring gene microRNA 3136

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ25161

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables receptor ligand activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables receptor ligand activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in macrophage chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in macrophage chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phagocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phagocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of sensory perception of pain IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of signaling receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in superoxide anion generation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    chemokine-like protein TAFA-4
    Names
    family with sequence similarity 19 (chemokine (C-C motif)-like), member A4
    family with sequence similarity 19 member A4, C-C motif chemokine like
    protein FAM19A4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005527.3NP_001005527.1  chemokine-like protein TAFA-4 precursor

      See identical proteins and their annotated locations for NP_001005527.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC096922, BC031566, DA017279
      Consensus CDS
      CCDS2907.1
      UniProtKB/Swiss-Prot
      A8MVT2, Q96LR4
      Conserved Domains (1) summary
      pfam12020
      Location:50138
      TAFA; TAFA family
    2. NM_182522.5NP_872328.1  chemokine-like protein TAFA-4 precursor

      See identical proteins and their annotated locations for NP_872328.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC096922, AY325117
      Consensus CDS
      CCDS2907.1
      UniProtKB/Swiss-Prot
      A8MVT2, Q96LR4
      Related
      ENSP00000295569.7, ENST00000295569.12
      Conserved Domains (1) summary
      pfam12020
      Location:50138
      TAFA; TAFA family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      68731766..68932547 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011533372.2XP_011531674.1  chemokine-like protein TAFA-4 isoform X1

      See identical proteins and their annotated locations for XP_011531674.1

      Conserved Domains (1) summary
      pfam12020
      Location:50124
      TAFA; TAFA family
    2. XM_011533371.2XP_011531673.1  chemokine-like protein TAFA-4 isoform X1

      See identical proteins and their annotated locations for XP_011531673.1

      Conserved Domains (1) summary
      pfam12020
      Location:50124
      TAFA; TAFA family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      68769008..68969284 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054345323.1XP_054201298.1  chemokine-like protein TAFA-4 isoform X1

    2. XM_054345322.1XP_054201297.1  chemokine-like protein TAFA-4 isoform X1