U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CIC capicua transcriptional repressor [ Homo sapiens (human) ]

    Gene ID: 23152, updated on 10-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CICprovided by HGNC
    Official Full Name
    capicua transcriptional repressorprovided by HGNC
    Primary source
    HGNC:HGNC:14214
    See related
    Ensembl:ENSG00000079432 MIM:612082; AllianceGenome:HGNC:14214
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MRD45
    Summary
    The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]
    Expression
    Ubiquitous expression in testis (RPKM 16.0), endometrium (RPKM 12.0) and 25 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CIC in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (42268530..42295796)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (45087903..45115169)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (42772682..42799948)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene glycogen synthase kinase 3 alpha Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10692 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10693 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:42747245-42748039 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:42748040-42748833 Neighboring gene Sharpr-MPRA regulatory region 11582 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10694 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10695 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10697 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10696 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:42758837-42759336 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:42759977-42760508 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:42761304-42762125 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:42762126-42762946 Neighboring gene ETS2 repressor factor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14710 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14711 Neighboring gene ZFP161 motif-containing MPRA enhancer 284/285 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:42784339-42784844 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10703 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:42785857-42786361 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:42787942-42788116 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:42794166-42795066 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10705 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14712 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14713 Neighboring gene platelet activating factor acetylhydrolase 1b catalytic subunit 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:42806463-42807117 Neighboring gene proline rich 19 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10707 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:42818801-42819301 Neighboring gene transmembrane protein 145

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. CIC inactivating mutations identify aggressive subset of 1p19q codeleted gliomas. Gleize V, et al. Ann Neurol, 2015 Sep. PMID 26017892
    2. Comparative transcriptome analysis of isogenic cell line models and primary cancers links capicua (CIC) loss to activation of the MAPK signalling cascade. LeBlanc VG, et al. J Pathol, 2017 Jun. PMID 28295365, Free PMC Article
    3. The "grep" command but not FusionMap, FusionFinder or ChimeraScan captures the CIC-DUX4 fusion gene from whole transcriptome sequencing data on a small round cell tumor with t(4;19)(q35;q13). Panagopoulos I, et al. PLoS One, 2014. PMID 24950227, Free PMC Article
    4. Downregulation of CIC does not associate with overexpression of ETV1 or MAP kinase pathway activation in gastrointestinal stromal tumors. Schoppmann SF, et al. Cancer Invest, 2014 Aug. PMID 24897389
    5. Clinicopathologic Features of a Series of Primary Renal CIC-rearranged Sarcomas With Comprehensive Molecular Analysis. Mangray S, et al. Am J Surg Pathol, 2018 Oct. PMID 29901569

    See all (126) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CIC-Rearranged Sarcoma.
      Title: CIC-Rearranged Sarcoma.
    2. Expanding the Molecular Diversity of CIC-Rearranged Sarcomas With Novel and Very Rare Partners.
      Title: Expanding the Molecular Diversity of CIC-Rearranged Sarcomas With Novel and Very Rare Partners.
    3. A global collaboRAtive study of CIC-rearranged, BCOR::CCNB3-rearranged and other ultra-rare unclassified undifferentiated small round cell sarcomas (GRACefUl).
      Title: A global collaboRAtive study of CIC-rearranged, BCOR::CCNB3-rearranged and other ultra-rare unclassified undifferentiated small round cell sarcomas (GRACefUl).
    4. CIC reduces xCT/SLC7A11 expression and glutamate release in glioma.
      Title: CIC reduces xCT/SLC7A11 expression and glutamate release in glioma.
    5. CIC missense variants contribute to susceptibility for spina bifida.
      Title: CIC missense variants contribute to susceptibility for spina bifida.
    6. The CIC-ERF co-deletion underlies fusion-independent activation of ETS family member, ETV1, to drive prostate cancer progression.
      Title: The CIC-ERF co-deletion underlies fusion-independent activation of ETS family member, ETV1, to drive prostate cancer progression.
    7. Capicua suppresses YAP1 to limit tumorigenesis and maintain drug sensitivity in human cancer.
      Title: Capicua suppresses YAP1 to limit tumorigenesis and maintain drug sensitivity in human cancer.
    8. CIC-NUTM1 Sarcomas Affecting the Spine.
      Title: CIC-NUTM1 Sarcomas Affecting the Spine.
    9. CIC de novo loss of function variants contribute to cerebral folate deficiency by downregulating FOLR1 expression.
      Title: CIC de novo loss of function variants contribute to cerebral folate deficiency by downregulating FOLR1 expression.
    10. Integrative multi-omic analysis reveals neurodevelopmental gene dysregulation in CIC-knockout and IDH1-mutant cells.
      Title: Integrative multi-omic analysis reveals neurodevelopmental gene dysregulation in CIC-knockout and IDH1-mutant cells.
    Submit: New GeneRIF Correction See all GeneRIFs (61)

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Intellectual disability, autosomal dominant 45
    MedGen: C4539848 OMIM: 617600 GeneReviews: Not available
    		Compare labs

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated 2022-11-08)

    ClinGen Genome Curation PagePubMed
    Triplosensitivity

    No evidence available (Last evaluated 2022-11-08)

    ClinGen Genome Curation Page

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • KIAA0306

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in brain development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in learning ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in memory ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in social behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    protein capicua homolog

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_042060.1 RefSeqGene

      Range
      5001..32260
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_999

    mRNA and Protein(s)

    1. NM_001304815.2 → NP_001291744.1  protein capicua homolog isoform CIC-L

      See identical proteins and their annotated locations for NP_001291744.1

      Status: REVIEWED

      Source sequence(s)
      AC006486
      Consensus CDS
      CCDS92632.1
      UniProtKB/Swiss-Prot
      A0A7P0T9K5, Q7LGI1, Q96RK0, Q9UEG5, Q9Y6T1
      Conserved Domains (5) summary
      PHA03247
      Location:1765 → 2185
      PHA03247; large tegument protein UL36; Provisional
      COG5648
      Location:1080 → 1224
      NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
      PRK14086
      Location:871 → 1046
      dnaA; chromosomal replication initiator protein DnaA
      cd01388
      Location:1108 → 1179
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam16090
      Location:252 → 349
      DUF4819; Domain of unknown function (DUF4819)

    2. NM_001379480.1 → NP_001366409.1  protein capicua homolog isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC006486
      Conserved Domains (5) summary
      PHA03247
      Location:1765 → 2184
      PHA03247; large tegument protein UL36; Provisional
      COG5648
      Location:1080 → 1224
      NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
      PRK14086
      Location:871 → 1046
      dnaA; chromosomal replication initiator protein DnaA
      cd01388
      Location:1108 → 1179
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam16090
      Location:252 → 349
      DUF4819; Domain of unknown function (DUF4819)

    3. NM_001379482.1 → NP_001366411.1  protein capicua homolog isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC006486
      Conserved Domains (5) summary
      PHA03247
      Location:1765 → 2185
      PHA03247; large tegument protein UL36; Provisional
      COG5648
      Location:1080 → 1224
      NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
      PRK14086
      Location:871 → 1046
      dnaA; chromosomal replication initiator protein DnaA
      cd01388
      Location:1108 → 1179
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam16090
      Location:252 → 349
      DUF4819; Domain of unknown function (DUF4819)

    4. NM_001379484.1 → NP_001366413.1  protein capicua homolog isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC006486
      UniProtKB/TrEMBL
      A7XAK3
      Conserved Domains (3) summary
      PHA03247
      Location:856 → 1276
      PHA03247; large tegument protein UL36; Provisional
      COG5648
      Location:171 → 315
      NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
      cd01388
      Location:199 → 270
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

    5. NM_001379485.1 → NP_001366414.1  protein capicua homolog isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC006486
      UniProtKB/TrEMBL
      A7XAK3
      Conserved Domains (3) summary
      PHA03247
      Location:856 → 1276
      PHA03247; large tegument protein UL36; Provisional
      COG5648
      Location:171 → 315
      NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
      cd01388
      Location:199 → 270
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

    6. NM_001386298.1 → NP_001373227.1  protein capicua homolog isoform CIC-L

      Status: REVIEWED

      Source sequence(s)
      AC006486
      Consensus CDS
      CCDS92632.1
      UniProtKB/Swiss-Prot
      A0A7P0T9K5, Q7LGI1, Q96RK0, Q9UEG5, Q9Y6T1
      Related
      ENSP00000505728.1, ENST00000681038.1
      Conserved Domains (5) summary
      PHA03247
      Location:1765 → 2185
      PHA03247; large tegument protein UL36; Provisional
      COG5648
      Location:1080 → 1224
      NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
      PRK14086
      Location:871 → 1046
      dnaA; chromosomal replication initiator protein DnaA
      cd01388
      Location:1108 → 1179
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam16090
      Location:252 → 349
      DUF4819; Domain of unknown function (DUF4819)

    7. NM_015125.5 → NP_055940.3  protein capicua homolog isoform CIC-S

      See identical proteins and their annotated locations for NP_055940.3

      Status: REVIEWED

      Source sequence(s)
      AC006486
      Consensus CDS
      CCDS12601.1
      UniProtKB/TrEMBL
      A7XAK3
      Related
      ENSP00000458663.2, ENST00000575354.6
      Conserved Domains (2) summary
      COG5648
      Location:171 → 315
      NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
      cd01388
      Location:199 → 270
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      42268530..42295796
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438497.1 → XP_047294453.1  protein capicua homolog isoform X6

    2. XM_047438493.1 → XP_047294449.1  protein capicua homolog isoform X3

    3. XM_047438498.1 → XP_047294454.1  protein capicua homolog isoform X9

    4. XM_047438495.1 → XP_047294451.1  protein capicua homolog isoform X5

    5. XM_047438503.1 → XP_047294459.1  protein capicua homolog isoform X13

    6. XM_011526665.3 → XP_011524967.1  protein capicua homolog isoform X6

      Conserved Domains (3) summary
      COG5648
      Location:1080 → 1224
      NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
      cd01388
      Location:1108 → 1179
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam16090
      Location:252 → 349
      DUF4819; Domain of unknown function (DUF4819)

    7. XM_011526666.3 → XP_011524968.1  protein capicua homolog isoform X9

      Conserved Domains (3) summary
      COG5648
      Location:1080 → 1224
      NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
      cd01388
      Location:1108 → 1179
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam16090
      Location:252 → 349
      DUF4819; Domain of unknown function (DUF4819)

    8. XM_024451433.2 → XP_024307201.1  protein capicua homolog isoform X8

      Conserved Domains (5) summary
      COG5648
      Location:1080 → 1224
      NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
      cd01388
      Location:1108 → 1179
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam16090
      Location:252 → 346
      DUF4819; Domain of unknown function (DUF4819)
      cl26464
      Location:1765 → 2184
      Atrophin-1; Atrophin-1 family
      cl28271
      Location:871 → 1046
      dnaA; chromosomal replication initiation protein; Provisional

    9. XM_024451432.2 → XP_024307200.1  protein capicua homolog isoform X5

      Conserved Domains (5) summary
      COG5648
      Location:1080 → 1224
      NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
      cd01388
      Location:1108 → 1179
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam16090
      Location:252 → 346
      DUF4819; Domain of unknown function (DUF4819)
      cl26464
      Location:1765 → 2184
      Atrophin-1; Atrophin-1 family
      cl28271
      Location:871 → 1046
      dnaA; chromosomal replication initiation protein; Provisional

    10. XM_047438502.1 → XP_047294458.1  protein capicua homolog isoform X13

    11. XM_011526662.3 → XP_011524964.1  protein capicua homolog isoform X2

      Conserved Domains (3) summary
      COG5648
      Location:1080 → 1224
      NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
      cd01388
      Location:1108 → 1179
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam16090
      Location:252 → 349
      DUF4819; Domain of unknown function (DUF4819)

    12. XM_047438500.1 → XP_047294456.1  protein capicua homolog isoform X11

    13. XM_047438496.1 → XP_047294452.1  protein capicua homolog isoform X7

    14. XM_047438504.1 → XP_047294460.1  protein capicua homolog isoform X14

    15. XM_011526664.3 → XP_011524966.1  protein capicua homolog isoform X4

      Conserved Domains (3) summary
      COG5648
      Location:1080 → 1224
      NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
      cd01388
      Location:1108 → 1179
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam16090
      Location:252 → 349
      DUF4819; Domain of unknown function (DUF4819)

    16. XM_047438501.1 → XP_047294457.1  protein capicua homolog isoform X12

    17. XM_047438499.1 → XP_047294455.1  protein capicua homolog isoform X10

      UniProtKB/TrEMBL
      I3L2J0
      Related
      ENSP00000459719.1, ENST00000572681.6

    18. XM_011526667.3 → XP_011524969.1  protein capicua homolog isoform X15

      Conserved Domains (4) summary
      PHA03247
      Location:1516 → 1973
      PHA03247; large tegument protein UL36; Provisional
      COG5648
      Location:1065 → 1224
      NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
      PRK14086
      Location:871 → 1046
      dnaA; chromosomal replication initiator protein DnaA
      cd01388
      Location:1108 → 1179
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

    19. XM_047438505.1 → XP_047294461.1  protein capicua homolog isoform X16

    20. XM_047438506.1 → XP_047294462.1  protein capicua homolog isoform X17

    21. XM_047438507.1 → XP_047294463.1  protein capicua homolog isoform X18

    22. XM_047438492.1 → XP_047294448.1  protein capicua homolog isoform X1

      UniProtKB/Swiss-Prot
      A0A7P0T9K5, Q7LGI1, Q96RK0, Q9UEG5, Q9Y6T1

    23. XM_047438511.1 → XP_047294467.1  protein capicua homolog isoform X25

      UniProtKB/TrEMBL
      A7XAK3

    24. XM_047438512.1 → XP_047294468.1  protein capicua homolog isoform X26

      UniProtKB/TrEMBL
      A7XAK3

    25. XM_047438509.1 → XP_047294465.1  protein capicua homolog isoform X20

      UniProtKB/TrEMBL
      A7XAK3

    26. XM_047438508.1 → XP_047294464.1  protein capicua homolog isoform X19

      UniProtKB/TrEMBL
      A7XAK3

    27. XM_005258674.3 → XP_005258731.1  protein capicua homolog isoform X22

      UniProtKB/TrEMBL
      A7XAK3
      Conserved Domains (2) summary
      COG5648
      Location:171 → 315
      NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
      cd01388
      Location:199 → 270
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

    28. XM_047438510.1 → XP_047294466.1  protein capicua homolog isoform X23

      UniProtKB/TrEMBL
      A7XAK3

    29. XM_005258673.3 → XP_005258730.1  protein capicua homolog isoform X21

      UniProtKB/TrEMBL
      A0A0A0MQR4, A7XAK3
      Related
      ENSP00000160740.3, ENST00000160740.7
      Conserved Domains (2) summary
      COG5648
      Location:171 → 315
      NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
      cd01388
      Location:199 → 270
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

    30. XM_005258675.3 → XP_005258732.1  protein capicua homolog isoform X24

      UniProtKB/TrEMBL
      A7XAK3
      Conserved Domains (2) summary
      COG5648
      Location:171 → 315
      NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
      cd01388
      Location:199 → 270
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

    31. XM_047438513.1 → XP_047294469.1  protein capicua homolog isoform X27

      UniProtKB/TrEMBL
      A7XAK3
      Related
      ENST00000684265.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      45087903..45115169
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320321.1 → XP_054176296.1  protein capicua homolog isoform X6

    2. XM_054320315.1 → XP_054176290.1  protein capicua homolog isoform X3

    3. XM_054320324.1 → XP_054176299.1  protein capicua homolog isoform X9

    4. XM_054320318.1 → XP_054176293.1  protein capicua homolog isoform X5

    5. XM_054320329.1 → XP_054176304.1  protein capicua homolog isoform X13

    6. XM_054320319.1 → XP_054176294.1  protein capicua homolog isoform X6

    7. XM_054320323.1 → XP_054176298.1  protein capicua homolog isoform X9

    8. XM_054320322.1 → XP_054176297.1  protein capicua homolog isoform X8

    9. XM_054320317.1 → XP_054176292.1  protein capicua homolog isoform X5

    10. XM_054320328.1 → XP_054176303.1  protein capicua homolog isoform X13

    11. XM_054320314.1 → XP_054176289.1  protein capicua homolog isoform X2

    12. XM_054320326.1 → XP_054176301.1  protein capicua homolog isoform X11

    13. XM_054320320.1 → XP_054176295.1  protein capicua homolog isoform X7

    14. XM_054320330.1 → XP_054176305.1  protein capicua homolog isoform X14

    15. XM_054320316.1 → XP_054176291.1  protein capicua homolog isoform X4

    16. XM_054320327.1 → XP_054176302.1  protein capicua homolog isoform X12

    17. XM_054320325.1 → XP_054176300.1  protein capicua homolog isoform X10

      UniProtKB/TrEMBL
      I3L2J0

    18. XM_054320331.1 → XP_054176306.1  protein capicua homolog isoform X15

    19. XM_054320332.1 → XP_054176307.1  protein capicua homolog isoform X16

    20. XM_054320333.1 → XP_054176308.1  protein capicua homolog isoform X17

    21. XM_054320334.1 → XP_054176309.1  protein capicua homolog isoform X18

    22. XM_054320313.1 → XP_054176288.1  protein capicua homolog isoform X1

      UniProtKB/Swiss-Prot
      A0A7P0T9K5, Q7LGI1, Q96RK0, Q9UEG5, Q9Y6T1

    23. XM_054320341.1 → XP_054176316.1  protein capicua homolog isoform X25

      UniProtKB/TrEMBL
      A7XAK3

    24. XM_054320342.1 → XP_054176317.1  protein capicua homolog isoform X26

      UniProtKB/TrEMBL
      A7XAK3

    25. XM_054320335.1 → XP_054176310.1  protein capicua homolog isoform X20

      UniProtKB/TrEMBL
      A7XAK3

    26. XM_054320336.1 → XP_054176311.1  protein capicua homolog isoform X19

      UniProtKB/TrEMBL
      A7XAK3

    27. XM_054320338.1 → XP_054176313.1  protein capicua homolog isoform X22

      UniProtKB/TrEMBL
      A7XAK3

    28. XM_054320339.1 → XP_054176314.1  protein capicua homolog isoform X23

      UniProtKB/TrEMBL
      A7XAK3

    29. XM_054320337.1 → XP_054176312.1  protein capicua homolog isoform X21

      UniProtKB/TrEMBL
      A0A0A0MQR4, A7XAK3

    30. XM_054320340.1 → XP_054176315.1  protein capicua homolog isoform X24

      UniProtKB/TrEMBL
      A7XAK3

    31. XM_054320343.1 → XP_054176318.1  protein capicua homolog isoform X27

      UniProtKB/TrEMBL
      A7XAK3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96RK0.3 GenPept UniProtKB/Swiss-Prot:Q96RK0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools