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    CYRIB CYFIP related Rac1 interactor B [ Homo sapiens (human) ]

    Gene ID: 51571, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CYRIBprovided by HGNC
    Official Full Name
    CYFIP related Rac1 interactor Bprovided by HGNC
    Primary source
    HGNC:HGNC:25216
    See related
    Ensembl:ENSG00000153310 MIM:617978; AllianceGenome:HGNC:25216
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    L1; CYRI; BM-009; CYRI-B; FAM49B
    Summary
    Enables small GTPase binding activity. Involved in several processes, including cellular response to molecule of bacterial origin; negative regulation of small GTPase mediated signal transduction; and regulation of organelle organization. Located in mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bone marrow (RPKM 26.7), appendix (RPKM 26.4) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CYRIB in Genome Data Viewer
    Location:
    8q24.21
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (129839593..130017129, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (130965555..131143607, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (130851839..131029375, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene CCDC26 long non-coding RNA Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:130526802-130527734 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:130527735-130528668 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19539 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27967 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27969 Neighboring gene microRNA 3686 Neighboring gene CRISPRi-validated CCDC26 and MYC e5 enhancer Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:130598970-130600169 Neighboring gene MPRA-validated peak7175 silencer Neighboring gene VISTA enhancer hs1709 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19540 Neighboring gene CRISPRi-validated CCDC26, MYC and PVT1 e6 enhancer Neighboring gene CRISPRi-validated CCDC26, MYC and PVT1 e7 enhancer Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:130719165-130720364 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:130722337-130723536 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:130725004-130725177 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27970 Neighboring gene mitochondrial translational release factor 1 like pseudogene 2 Neighboring gene gasdermin C Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:130844878-130845690 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:130845691-130846502 Neighboring gene uncharacterized LOC124900265 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:130881998-130882552 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:130882553-130883105 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27971 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:130899605-130900116 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:130899091-130899604 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27972 Neighboring gene MPRA-validated peak7177 silencer Neighboring gene ribosomal protein L15 pseudogene 12 Neighboring gene Sharpr-MPRA regulatory region 603 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19541 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27973 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:130957594-130958094 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:130971367-130971867 Neighboring gene MPRA-validated peak7178 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27974 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27975 Neighboring gene uncharacterized LOC124902025 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27976 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:131005193-131005693 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19542 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19543 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19544 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19545 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:131054337-131055152 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27979 Neighboring gene RNA, U7 small nuclear 181 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr8:131067248-131067450 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:131081877-131082759 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27980 Neighboring gene microRNA 5194 Neighboring gene RNA, U6 small nuclear 1255, pseudogene Neighboring gene ASAP1 intronic transcript 2 Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A genome-wide genetic screen identifies CYRI-B as a negative regulator of CEACAM3-mediated phagocytosis. Kuiper JWP, et al. J Cell Sci, 2023 Jun 1. PMID 37264948
    2. Genome-wide CRISPR screen identifies FAM49B as a key regulator of actin dynamics and T cell activation. Shang W, et al. Proc Natl Acad Sci U S A, 2018 Apr 24. PMID 29632189, Free PMC Article
    3. TASP1 Promotes Gallbladder Cancer Cell Proliferation and Metastasis by Up-regulating FAM49B via PI3K/AKT Pathway. Zhang Y, et al. Int J Biol Sci, 2020. PMID 32071545, Free PMC Article
    4. Structural Basis of CYRI-B Direct Competition with Scar/WAVE Complex for Rac1. Yelland T, et al. Structure, 2021 Mar 4. PMID 33217330, Free PMC Article
    5. GOLM1 and FAM49B: Potential Biomarkers in HNSCC Based on Bioinformatics and Immunohistochemical Analysis. Xi Y, et al. Int J Mol Sci, 2022 Dec 6. PMID 36499755, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CYRI-B-mediated macropinocytosis drives metastasis via lysophosphatidic acid receptor uptake.
      Title: CYRI-B-mediated macropinocytosis drives metastasis via lysophosphatidic acid receptor uptake.
    2. LANCL1, a cell surface protein, promotes liver tumor initiation through FAM49B-Rac1 axis to suppress oxidative stress.
      Title: LANCL1, a cell surface protein, promotes liver tumor initiation through FAM49B-Rac1 axis to suppress oxidative stress.
    3. A genome-wide genetic screen identifies CYRI-B as a negative regulator of CEACAM3-mediated phagocytosis.
      Title: A genome-wide genetic screen identifies CYRI-B as a negative regulator of CEACAM3-mediated phagocytosis.
    4. GOLM1 and FAM49B: Potential Biomarkers in HNSCC Based on Bioinformatics and Immunohistochemical Analysis.
      Title: GOLM1 and FAM49B: Potential Biomarkers in HNSCC Based on Bioinformatics and Immunohistochemical Analysis.
    5. Structural Basis of CYRI-B Direct Competition with Scar/WAVE Complex for Rac1.
      Title: Structural Basis of CYRI-B Direct Competition with Scar/WAVE Complex for Rac1.
    6. TASP1 Promotes Gallbladder Cancer Cell Proliferation and Metastasis by Up-regulating FAM49B via PI3K/AKT Pathway.
      Title: TASP1 Promotes Gallbladder Cancer Cell Proliferation and Metastasis by Up-regulating FAM49B via PI3K/AKT Pathway.
    7. CYFIP related Rac1 interactor B (CYRI) binds to the small GTPase RAC1 through a conserved domain present in CYFIP proteins. CYRI negatively regulates RAC1 signalling, thereby attenuating processes such as macropinocytosis, phagocytosis and cell migration. This enables CYRI to counteract Salmonella at various stages of infection. The bacterial effector SopE, a RAC1 activator, selectively targets CYRI following infection.
      Title: CYRI/FAM49B negatively regulates RAC1-driven cytoskeletal remodelling and protects against bacterial infection.
    8. Low fam49B expression is associated with pancreatic ductal adenocarcinoma metastasis.
      Title: FAM49B, a novel regulator of mitochondrial function and integrity that suppresses tumor metastasis.
    9. FAM49B inhibits T cell activation by repressing Rac activity and modulating cytoskeleton reorganization.
      Title: Genome-wide CRISPR screen identifies FAM49B as a key regulator of actin dynamics and T cell activation.
    10. Three proteins-matrix metalloproteinase-9, neutrophil elastase, and FAM49B-were significantly lower in abundance in samples from women with endometriosis.
      Title: Urine, peritoneal fluid and omental fat proteomes of reproductive age women: Endometriosis-related changes and associations with endocrine disrupting chemicals.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies protein quantitative trait loci (pQTLs).
    EBI GWAS Catalog
    Genome-wide association study identifies new susceptibility loci for posttraumatic stress disorder.
    EBI GWAS Catalog
    Multiple loci are associated with white blood cell phenotypes.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp686B04128

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables MHC class Ib protein binding, via antigen binding groove ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to molecule of bacterial origin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of actin filament polymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of small GTPase mediated signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of T cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of T cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of T cell mediated cytotoxicity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of memory T cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of type II interferon production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of establishment of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitochondrial fission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in platelet alpha granule lumen TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    CYFIP-related Rac1 interactor B
    Names
    FAM49B/JPH1 fusion
    MTSS1/FAM49B fusion
    family with sequence similarity 49 member B
    protein FAM49B

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256763.2 → NP_001243692.1  CYFIP-related Rac1 interactor B isoform 1

      See identical proteins and their annotated locations for NP_001243692.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) and variant 2 encode the same protein.
      Source sequence(s)
      AC022973, AK130372, BC003599, BX419336
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Related
      ENSP00000429499.1, ENST00000519540.5
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    2. NM_001330612.2 → NP_001317541.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AA975908, AC022973, CN362384, CX165551
      Consensus CDS
      CCDS83327.1
      UniProtKB/Swiss-Prot
      Q9NUQ9
      Related
      ENSP00000429978.1, ENST00000522250.5
      Conserved Domains (1) summary
      pfam07159
      Location:1 → 174
      DUF1394; Protein of unknown function (DUF1394)

    3. NM_001353242.2 → NP_001340171.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an exon and includes three alternate exons in the 5' region, compared to variant 1.
      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Related
      ENSP00000384880.2, ENST00000401979.6
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    4. NM_001353243.2 → NP_001340172.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks two exons and includes three alternate exons in the 5' region, compared to variant 1.
      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Related
      ENSP00000429802.1, ENST00000523509.5
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    5. NM_001353244.2 → NP_001340173.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) includes two alternate internal exons, compared to variant 1.
      Source sequence(s)
      AC022973
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Related
      ENSP00000428117.1, ENST00000522746.5
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    6. NM_001353245.1 → NP_001340174.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    7. NM_001353246.1 → NP_001340175.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    8. NM_001353247.1 → NP_001340176.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    9. NM_001353248.2 → NP_001340177.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    10. NM_001353249.1 → NP_001340178.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    11. NM_001353250.1 → NP_001340179.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Related
      ENSP00000429078.1, ENST00000519110.5
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    12. NM_001353251.1 → NP_001340180.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    13. NM_001353252.1 → NP_001340181.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    14. NM_001353253.1 → NP_001340182.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    15. NM_001353254.2 → NP_001340183.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    16. NM_001353255.1 → NP_001340184.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    17. NM_001353256.2 → NP_001340185.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    18. NM_001353257.2 → NP_001340186.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    19. NM_001353258.2 → NP_001340187.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Related
      ENSP00000511587.1, ENST00000694912.1
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    20. NM_001353259.2 → NP_001340188.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    21. NM_001353260.2 → NP_001340189.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Related
      ENSP00000430674.1, ENST00000517654.5
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    22. NM_001353261.2 → NP_001340190.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    23. NM_001353262.2 → NP_001340191.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    24. NM_001353263.2 → NP_001340192.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    25. NM_001353264.2 → NP_001340193.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    26. NM_001353265.2 → NP_001340194.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    27. NM_001353266.2 → NP_001340195.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    28. NM_001353267.2 → NP_001340196.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    29. NM_001353268.2 → NP_001340197.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    30. NM_001353269.1 → NP_001340198.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1 → 174
      DUF1394; Protein of unknown function (DUF1394)

    31. NM_001353270.1 → NP_001340199.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1 → 174
      DUF1394; Protein of unknown function (DUF1394)

    32. NM_001353271.1 → NP_001340200.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1 → 174
      DUF1394; Protein of unknown function (DUF1394)

    33. NM_001353272.1 → NP_001340201.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1 → 174
      DUF1394; Protein of unknown function (DUF1394)

    34. NM_001353273.1 → NP_001340202.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1 → 174
      DUF1394; Protein of unknown function (DUF1394)

    35. NM_001353274.1 → NP_001340203.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1 → 174
      DUF1394; Protein of unknown function (DUF1394)

    36. NM_001353275.1 → NP_001340204.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1 → 174
      DUF1394; Protein of unknown function (DUF1394)

    37. NM_001353276.2 → NP_001340205.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1 → 174
      DUF1394; Protein of unknown function (DUF1394)

    38. NM_001353277.1 → NP_001340206.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1 → 174
      DUF1394; Protein of unknown function (DUF1394)

    39. NM_001353278.1 → NP_001340207.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1 → 174
      DUF1394; Protein of unknown function (DUF1394)

    40. NM_001353279.1 → NP_001340208.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1 → 174
      DUF1394; Protein of unknown function (DUF1394)

    41. NM_001353280.1 → NP_001340209.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1 → 174
      DUF1394; Protein of unknown function (DUF1394)

    42. NM_001353281.1 → NP_001340210.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1 → 174
      DUF1394; Protein of unknown function (DUF1394)

    43. NM_001353282.2 → NP_001340211.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1 → 174
      DUF1394; Protein of unknown function (DUF1394)

    44. NM_001353283.2 → NP_001340212.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1 → 174
      DUF1394; Protein of unknown function (DUF1394)

    45. NM_001353284.2 → NP_001340213.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1 → 174
      DUF1394; Protein of unknown function (DUF1394)

    46. NM_001353285.2 → NP_001340214.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1 → 174
      DUF1394; Protein of unknown function (DUF1394)

    47. NM_001353286.2 → NP_001340215.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1 → 174
      DUF1394; Protein of unknown function (DUF1394)

    48. NM_001353287.2 → NP_001340216.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1 → 174
      DUF1394; Protein of unknown function (DUF1394)

    49. NM_001353288.2 → NP_001340217.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1 → 174
      DUF1394; Protein of unknown function (DUF1394)

    50. NM_001353289.2 → NP_001340218.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1 → 174
      DUF1394; Protein of unknown function (DUF1394)

    51. NM_001353290.2 → NP_001340219.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1 → 174
      DUF1394; Protein of unknown function (DUF1394)

    52. NM_001353291.2 → NP_001340220.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1 → 174
      DUF1394; Protein of unknown function (DUF1394)

    53. NM_001353292.2 → NP_001340221.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1 → 174
      DUF1394; Protein of unknown function (DUF1394)

    54. NM_001353293.2 → NP_001340222.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1 → 174
      DUF1394; Protein of unknown function (DUF1394)

    55. NM_001353294.2 → NP_001340223.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1 → 174
      DUF1394; Protein of unknown function (DUF1394)

    56. NM_001353295.2 → NP_001340224.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1 → 174
      DUF1394; Protein of unknown function (DUF1394)

    57. NM_001353296.2 → NP_001340225.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1 → 174
      DUF1394; Protein of unknown function (DUF1394)

    58. NM_001353297.2 → NP_001340226.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1 → 174
      DUF1394; Protein of unknown function (DUF1394)

    59. NM_001353298.2 → NP_001340227.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1 → 174
      DUF1394; Protein of unknown function (DUF1394)

    60. NM_001353299.2 → NP_001340228.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1 → 174
      DUF1394; Protein of unknown function (DUF1394)

    61. NM_001353300.2 → NP_001340229.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1 → 174
      DUF1394; Protein of unknown function (DUF1394)

    62. NM_001353301.2 → NP_001340230.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973
      Consensus CDS
      CCDS83327.1
      Related
      ENSP00000430433.1, ENST00000522941.5
      Conserved Domains (1) summary
      pfam07159
      Location:1 → 174
      DUF1394; Protein of unknown function (DUF1394)

    63. NM_001353302.1 → NP_001340231.1  CYFIP-related Rac1 interactor B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS94340.1
      UniProtKB/TrEMBL
      A0A8V8TMP7, Q68D08
      Related
      ENSP00000515265.1, ENST00000703342.1
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    64. NM_001353303.1 → NP_001340232.1  CYFIP-related Rac1 interactor B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS94340.1
      UniProtKB/TrEMBL
      A0A8V8TMP7, Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    65. NM_001353304.1 → NP_001340233.1  CYFIP-related Rac1 interactor B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS94340.1
      UniProtKB/TrEMBL
      A0A8V8TMP7, Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    66. NM_001353305.1 → NP_001340234.1  CYFIP-related Rac1 interactor B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS94340.1
      UniProtKB/TrEMBL
      A0A8V8TMP7, Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    67. NM_001353306.2 → NP_001340235.1  CYFIP-related Rac1 interactor B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS94340.1
      UniProtKB/TrEMBL
      A0A8V8TMP7, Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    68. NM_001353307.2 → NP_001340236.1  CYFIP-related Rac1 interactor B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS94340.1
      UniProtKB/TrEMBL
      A0A8V8TMP7, Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    69. NM_001353308.1 → NP_001340237.1  CYFIP-related Rac1 interactor B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS94340.1
      UniProtKB/TrEMBL
      A0A8V8TMP7, Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    70. NM_001353309.1 → NP_001340238.1  CYFIP-related Rac1 interactor B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS94340.1
      UniProtKB/TrEMBL
      A0A8V8TMP7, Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    71. NM_001353310.2 → NP_001340239.1  CYFIP-related Rac1 interactor B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS94340.1
      UniProtKB/TrEMBL
      A0A8V8TMP7, Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    72. NM_001353311.2 → NP_001340240.1  CYFIP-related Rac1 interactor B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568, KF495742
      Consensus CDS
      CCDS94340.1
      UniProtKB/TrEMBL
      A0A8V8TMP7, Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    73. NM_001353312.2 → NP_001340241.1  CYFIP-related Rac1 interactor B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS94340.1
      UniProtKB/TrEMBL
      A0A8V8TMP7, Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    74. NM_001353313.2 → NP_001340242.1  CYFIP-related Rac1 interactor B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC022973
      Consensus CDS
      CCDS94340.1
      UniProtKB/TrEMBL
      A0A8V8TMP7, Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    75. NM_001353314.2 → NP_001340243.1  CYFIP-related Rac1 interactor B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC022973
      Consensus CDS
      CCDS94340.1
      UniProtKB/TrEMBL
      A0A8V8TMP7, Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    76. NM_001353315.2 → NP_001340244.1  CYFIP-related Rac1 interactor B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC022973
      Consensus CDS
      CCDS94340.1
      UniProtKB/TrEMBL
      A0A8V8TMP7, Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    77. NM_001353316.2 → NP_001340245.1  CYFIP-related Rac1 interactor B isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:17 → 312
      DUF1394; Protein of unknown function (DUF1394)

    78. NM_016623.5 → NP_057707.3  CYFIP-related Rac1 interactor B isoform 1

      See identical proteins and their annotated locations for NP_057707.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC022973, AK130372, BX419336
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Related
      ENSP00000429150.1, ENST00000519824.6
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      129839593..130017129 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421855.1 → XP_047277811.1  CYFIP-related Rac1 interactor B isoform X2

      UniProtKB/TrEMBL
      Q68D08

    2. XM_011517121.4 → XP_011515423.2  CYFIP-related Rac1 interactor B isoform X1

    3. XM_047421856.1 → XP_047277812.1  CYFIP-related Rac1 interactor B isoform X3

      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08

    4. XM_024447180.2 → XP_024302948.1  CYFIP-related Rac1 interactor B isoform X3

      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    5. XM_047421859.1 → XP_047277815.1  CYFIP-related Rac1 interactor B isoform X3

      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08

    6. XM_047421857.1 → XP_047277813.1  CYFIP-related Rac1 interactor B isoform X3

      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      130965555..131143607 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360636.1 → XP_054216611.1  CYFIP-related Rac1 interactor B isoform X2

      UniProtKB/TrEMBL
      Q68D08

    2. XM_054360635.1 → XP_054216610.1  CYFIP-related Rac1 interactor B isoform X1

    3. XM_054360638.1 → XP_054216613.1  CYFIP-related Rac1 interactor B isoform X3

      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08

    4. XM_054360637.1 → XP_054216612.1  CYFIP-related Rac1 interactor B isoform X3

      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08

    5. XM_054360640.1 → XP_054216615.1  CYFIP-related Rac1 interactor B isoform X3

      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08

    6. XM_054360639.1 → XP_054216614.1  CYFIP-related Rac1 interactor B isoform X3

      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NUQ9.1 GenPept UniProtKB/Swiss-Prot:Q9NUQ9

    Gene LinkOut

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