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    Acsm4 acyl-CoA synthetase medium-chain family member 4 [ Mus musculus (house mouse) ]

    Gene ID: 233801, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Acsm4provided by MGI
    Official Full Name
    acyl-CoA synthetase medium-chain family member 4provided by MGI
    Primary source
    MGI:MGI:2681844
    See related
    Ensembl:ENSMUSG00000047026 AllianceGenome:MGI:2681844
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    OMACS; O-MACS
    Summary
    Predicted to enable decanoate-CoA ligase activity and fatty-acyl-CoA synthase activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid biosynthetic process. Located in mitochondrion. Is expressed in nervous system; nose; and olfactory epithelium. Orthologous to human ACSM4 (acyl-CoA synthetase medium chain family member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Acsm4 in Genome Data Viewer
    Location:
    7 F2; 7 64.1 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (119289249..119313789)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (119690026..119714566)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39078 Neighboring gene predicted gene, 39079 Neighboring gene acyl-CoA synthetase medium-chain family member 1 Neighboring gene STARR-seq mESC enhancer starr_20036 Neighboring gene THUMP domain containing 1 Neighboring gene predicted gene, 39080

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Elimination of adult-born neurons in the olfactory bulb is promoted during the postprandial period. Yokoyama TK, et al. Neuron, 2011 Sep 8. PMID 21903081
    2. Primary dendrites of mitral cells synapse unto neighboring glomeruli independent of their odorant receptor identity. Nishizumi H, et al. Commun Biol, 2019. PMID 30652126, Free PMC Article
    3. Innate versus learned odour processing in the mouse olfactory bulb. Kobayakawa K, et al. Nature, 2007 Nov 22. PMID 17989651
    4. Agonist-independent GPCR activity regulates anterior-posterior targeting of olfactory sensory neurons. Nakashima A, et al. Cell, 2013 Sep 12. PMID 24034253, Free PMC Article
    5. Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation. Matsuo T, et al. Nat Commun, 2021 Apr 6. PMID 33824316, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC56918

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables decanoate-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables decanoate-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables fatty acid ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty acid ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fatty acid ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables fatty-acyl-CoA synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty-acyl-CoA synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fatty-acyl-CoA synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in acyl-CoA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in acyl-CoA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    acyl-coenzyme A synthetase ACSM4, mitochondrial
    Names
    olfactory specific medium-chain acyl CoA synthetase
    NP_848501.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178414.3 → NP_848501.1  acyl-coenzyme A synthetase ACSM4, mitochondrial precursor

      See identical proteins and their annotated locations for NP_848501.1

      Status: VALIDATED

      Source sequence(s)
      AK132127, BY588281
      Consensus CDS
      CCDS21784.1
      UniProtKB/Swiss-Prot
      Q80W40
      Related
      ENSMUSP00000045160.9, ENSMUST00000047045.10
      Conserved Domains (2) summary
      cd05928
      Location:48 → 577
      MACS_euk; Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM)
      COG0365
      Location:49 → 576
      Acs; Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      119289249..119313789
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80W40.1 GenPept UniProtKB/Swiss-Prot:Q80W40

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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