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    Cers4 ceramide synthase 4 [ Mus musculus (house mouse) ]

    Gene ID: 67260, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cers4provided by MGI
    Official Full Name
    ceramide synthase 4provided by MGI
    Primary source
    MGI:MGI:1914510
    See related
    Ensembl:ENSMUSG00000008206 AllianceGenome:MGI:1914510
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Trh1; Lass4; 2900019C14Rik
    Summary
    Enables sphingosine N-acyltransferase activity. Acts upstream of or within ceramide biosynthetic process. Located in endoplasmic reticulum. Is expressed in nervous system; nose; oral epithelium; and skin. Orthologous to human CERS4 (ceramide synthase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 11.0), lung adult (RPKM 8.8) and 23 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Cers4 in Genome Data Viewer
    Location:
    8 A1.1; 8 2.04 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (4542863..4579603)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (4492818..4529603)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene 7434 Neighboring gene peptidylprolyl isomerase A pseudogene 8_36.1 Neighboring gene STARR-seq mESC enhancer starr_20617 Neighboring gene vomeronasal 2, receptor, pseudogene 89 Neighboring gene STARR-seq mESC enhancer starr_20618 Neighboring gene STARR-seq mESC enhancer starr_20619 Neighboring gene STARR-seq mESC enhancer starr_20620 Neighboring gene zinc finger protein 958

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding  
    enables sphingosine N-acyltransferase activity  
    enables sphingosine N-acyltransferase activity PubMed 
    enables sphingosine N-acyltransferase activity  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum PubMed 
    located_in endoplasmic reticulum membrane  

    General protein information

    Preferred Names
    ceramide synthase 4
    Names
    LAG1 homolog, ceramide synthase 4
    LAG1 longevity assurance homolog 4
    TRAM homolog 1
    longevity assurance homolog 4
    sphingosine N-acyltransferase CERS4
    translocating chain-associating membrane protein homolog 1
    NP_080334.3
    XP_006508924.1
    XP_006508925.1
    XP_006508926.1
    XP_030099592.1
    XP_036010142.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026058.4NP_080334.3  ceramide synthase 4

      See identical proteins and their annotated locations for NP_080334.3

      Status: VALIDATED

      Source sequence(s)
      AK028937, AK076409, AV360657, BB006809, CK617511
      Consensus CDS
      CCDS22086.1
      UniProtKB/Swiss-Prot
      Q8BZA6, Q8C151, Q9CX09, Q9D6J1
      Related
      ENSMUSP00000008350.9, ENSMUST00000008350.16
      Conserved Domains (2) summary
      smart00724
      Location:131332
      TLC; TRAM, LAG1 and CLN8 homology domains
      cd00086
      Location:83128
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      4542863..4579603
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243732.2XP_030099592.1  ceramide synthase 4 isoform X1

      UniProtKB/Swiss-Prot
      Q8BZA6, Q8C151, Q9CX09, Q9D6J1
      Conserved Domains (2) summary
      smart00724
      Location:131332
      TLC; TRAM, LAG1 and CLN8 homology domains
      cd00086
      Location:83128
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    2. XM_006508861.4XP_006508924.1  ceramide synthase 4 isoform X1

      See identical proteins and their annotated locations for XP_006508924.1

      UniProtKB/Swiss-Prot
      Q8BZA6, Q8C151, Q9CX09, Q9D6J1
      Conserved Domains (2) summary
      smart00724
      Location:131332
      TLC; TRAM, LAG1 and CLN8 homology domains
      cd00086
      Location:83128
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    3. XM_006508863.4XP_006508926.1  ceramide synthase 4 isoform X1

      See identical proteins and their annotated locations for XP_006508926.1

      UniProtKB/Swiss-Prot
      Q8BZA6, Q8C151, Q9CX09, Q9D6J1
      Conserved Domains (2) summary
      smart00724
      Location:131332
      TLC; TRAM, LAG1 and CLN8 homology domains
      cd00086
      Location:83128
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    4. XM_036154249.1XP_036010142.1  ceramide synthase 4 isoform X1

      UniProtKB/Swiss-Prot
      Q8BZA6, Q8C151, Q9CX09, Q9D6J1
      Conserved Domains (2) summary
      smart00724
      Location:131332
      TLC; TRAM, LAG1 and CLN8 homology domains
      cd00086
      Location:83128
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    5. XM_006508862.5XP_006508925.1  ceramide synthase 4 isoform X1

      See identical proteins and their annotated locations for XP_006508925.1

      UniProtKB/Swiss-Prot
      Q8BZA6, Q8C151, Q9CX09, Q9D6J1
      Conserved Domains (2) summary
      smart00724
      Location:131332
      TLC; TRAM, LAG1 and CLN8 homology domains
      cd00086
      Location:83128
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    RNA

    1. XR_003947330.1 RNA Sequence

    2. XR_003947331.2 RNA Sequence

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