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    Tlx1 T cell leukemia, homeobox 1 [ Mus musculus (house mouse) ]

    Gene ID: 21908, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tlx1provided by MGI
    Official Full Name
    T cell leukemia, homeobox 1provided by MGI
    Primary source
    MGI:MGI:98769
    See related
    Ensembl:ENSMUSG00000025215 AllianceGenome:MGI:98769
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hox11; Tlx-1; Hox-11
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including nervous system development; positive regulation of stem cell proliferation; and spleen development. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; branchial arch; ear; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in adult T-cell leukemia/lymphoma. Orthologous to human TLX1 (T cell leukemia homeobox 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward spleen adult (RPKM 16.3) See more
    Orthologs
    human all
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    Genomic context

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    See Tlx1 in Genome Data Viewer
    Location:
    19 C3; 19 38.45 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (45138531..45145382)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (45150092..45156943)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_46258 Neighboring gene STARR-seq mESC enhancer starr_46259 Neighboring gene predicted gene, 35867 Neighboring gene STARR-seq mESC enhancer starr_46262 Neighboring gene predicted gene, 35923 Neighboring gene STARR-seq mESC enhancer starr_46263 Neighboring gene STARR-seq mESC enhancer starr_46264 Neighboring gene ladybird homeobox 1 Neighboring gene STARR-seq mESC enhancer starr_46267 Neighboring gene predicted gene 29595

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Tlx1 regulates acinar and duct development in mouse salivary glands. Hand AR, et al. J Anat, 2024 Feb. PMID 37837237,
    2. Specific homeodomain-DNA interactions are required for HOX11-mediated transformation. Owens BM, et al. Blood, 2003 Jun 15. PMID 12586625
    3. A negative regulatory region of the murine Hox11 gene. Arai Y, et al. Gene, 1997 Jul 1. PMID 9249069
    4. B-1a B cells that link the innate and adaptive immune responses are lacking in the absence of the spleen. Wardemann H, et al. J Exp Med, 2002 Mar 18. PMID 11901202, Free PMC Article
    5. Two forms of Hox11 a T cell leukemia oncogene, are expressed in fetal spleen but not in primary lymphocytes. Yamamoto H, et al. Mol Immunol, 1995 Nov. PMID 8559142

    See all (88) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tlx1 regulates acinar and duct development in mouse salivary glands.
      Title: Tlx1 regulates acinar and duct development in mouse salivary glands.
    2. Hox11 expression characterizes developing zeugopod synovial joints and is coupled to postnatal articular cartilage morphogenesis into functional zones in mice.
      Title: Hox11 expression characterizes developing zeugopod synovial joints and is coupled to postnatal articular cartilage morphogenesis into functional zones in mice.
    3. Transcription factor Tlx1 marks a subset of lymphoid tissue organizer-like mesenchymal progenitor cells in the neonatal spleen.
      Title: Transcription factor Tlx1 marks a subset of lymphoid tissue organizer-like mesenchymal progenitor cells in the neonatal spleen.
    4. High TLX1 expression is associated with castration-resistant prostate cancer.
      Title: Orphan nuclear receptor TLX contributes to androgen insensitivity in castration-resistant prostate cancer via its repression of androgen receptor transcription.
    5. data supports multiple roles for Hox11 genes following fracture injury in the adult skeleton
      Title: Hox11 Function Is Required for Region-Specific Fracture Repair.
    6. TLX1-dependent regulation of retinoic acid metabolism is critical for spleen organogenesis.
      Title: Transcription factor TLX1 controls retinoic acid signaling to ensure spleen development.
    7. Loss of Hox11 function leads to fracture repair defects, including reduced cartilage formation and delayed ossification.
      Title: Regionally Restricted Hox Function in Adult Bone Marrow Multipotent Mesenchymal Stem/Stromal Cells.
    8. Tlx1(CreER-Venus) mice represent a new tool for lineage tracing and conditional gene manipulation of spleen mesenchymal cells during morphogenesis.
      Title: Generation of a Tlx1(CreER-Venus) knock-in mouse strain for the study of spleen development.
    9. Hox11 genes are expressed in the connective tissue fibroblasts of the outer perichondrium, tendons and muscle connective tissue of the zeugopod region throughout all stages of development.
      Title: Hox11 genes are required for regional patterning and integration of muscle, tendon and bone.
    10. Tlx1/3 and Ptf1a, the key transcription factors for fate determination of glutamatergic and GABAergic neurons in the dorsal spinal cord
      Title: Tlx1/3 and Ptf1a control the expression of distinct sets of transmitter and peptide receptor genes in the developing dorsal spinal cord.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in animal organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within animal organ formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within central nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lymph node development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within spleen development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within spleen development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    T-cell leukemia homeobox protein 1
    Names
    homeobox TLX-1
    homeobox protein Hox-11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021901.3 → NP_068701.1  T-cell leukemia homeobox protein 1

      See identical proteins and their annotated locations for NP_068701.1

      Status: VALIDATED

      Source sequence(s)
      AC170878
      Consensus CDS
      CCDS29858.1
      UniProtKB/Swiss-Prot
      P43345
      UniProtKB/TrEMBL
      Q9QX99
      Related
      ENSMUSP00000026236.9, ENSMUST00000026236.11
      Conserved Domains (1) summary
      pfam00046
      Location:207 → 260
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      45138531..45145382
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526915.4 → XP_006526978.1  T-cell leukemia homeobox protein 1 isoform X1

      UniProtKB/Swiss-Prot
      P43345
      Conserved Domains (1) summary
      pfam00046
      Location:219 → 273
      Homeobox; Homeobox domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43345.1 GenPept UniProtKB/Swiss-Prot:P43345

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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