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    Zfp937 zinc finger protein 937 [ Mus musculus (house mouse) ]

    Gene ID: 245174, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp937provided by MGI
    Official Full Name
    zinc finger protein 937provided by MGI
    Primary source
    MGI:MGI:3644476
    See related
    Ensembl:ENSMUSG00000060336 AllianceGenome:MGI:3644476
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm4979; ZIPO-I; EG245174
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in central nervous system and genitourinary system. Orthologous to several human genes including ZNF117 (zinc finger protein 117); ZNF490 (zinc finger protein 490); and ZNF708 (zinc finger protein 708). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bladder adult (RPKM 1.1), CNS E11.5 (RPKM 1.0) and 25 other tissues See more
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    Genomic context

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    See Zfp937 in Genome Data Viewer
    Location:
    2 G3; 2 74.15 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (150059997..150088658)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (150218077..150246738)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 10770 Neighboring gene predicted gene, 52531 Neighboring gene zinc finger protein 1004 Neighboring gene STARR-seq mESC enhancer starr_05999 Neighboring gene STARR-seq mESC enhancer starr_06000 Neighboring gene zinc finger protein 1005 Neighboring gene RIKEN cDNA 3300002I08 gene Neighboring gene STARR-seq mESC enhancer starr_06001 Neighboring gene mitochondrial ribosomal protein L47 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    2. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein family member
    Names
    zinc-finger protein in podocyte I

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142411.2 → NP_001135883.1  zinc finger protein family member

      See identical proteins and their annotated locations for NP_001135883.1

      Status: VALIDATED

      Source sequence(s)
      AL831742, AL929042
      Consensus CDS
      CCDS50738.1
      UniProtKB/TrEMBL
      A2ANU7
      Related
      ENSMUSP00000073454.4, ENSMUST00000073782.4
      Conserved Domains (5) summary
      smart00349
      Location:4 → 57
      KRAB; krueppel associated box
      COG5048
      Location:86 → 486
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:217 → 237
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 43
      KRAB; KRAB box
      pfam13465
      Location:453 → 476
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      150059997..150088658
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251209.1 → XP_030107069.1  zinc finger protein family member isoform X1

      Conserved Domains (4) summary
      COG5048
      Location:121 → 397
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:217 → 237
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 44
      KRAB; KRAB box
      pfam13465
      Location:425 → 450
      zf-H2C2_2; Zinc-finger double domain

    2. XM_030251210.1 → XP_030107070.1  zinc finger protein family member isoform X2

      Conserved Domains (4) summary
      COG5048
      Location:164 → 393
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:60 → 150
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:185 → 205
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:421 → 446
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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