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    Cntnap5c contactin associated protein-like 5C [ Mus musculus (house mouse) ]

    Gene ID: 620292, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cntnap5cprovided by MGI
    Official Full Name
    contactin associated protein-like 5Cprovided by MGI
    Primary source
    MGI:MGI:3646013
    See related
    Ensembl:ENSMUSG00000038048 AllianceGenome:MGI:3646013
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm325; Caspr5-3; EG620292
    Summary
    Predicted to be involved in cell adhesion. Predicted to be located in membrane and neuron projection. Is expressed in CA1 pyramidal cell layer; brain; central nervous system; and hippocampus CA3. Orthologous to human CNTNAP5 (contactin associated protein family member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E18 (RPKM 1.3), frontal lobe adult (RPKM 0.7) and 6 other tissues See more
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    Genomic context

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    See Cntnap5c in Genome Data Viewer
    Location:
    17 D; 17 30.01 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (58076070..58724948)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (57769074..58417953)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 25102 Neighboring gene tubulin, beta 5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_42926 Neighboring gene ribosomal protein L7A, pseudogene 5 Neighboring gene STARR-seq mESC enhancer starr_42927 Neighboring gene STARR-seq mESC enhancer starr_42928 Neighboring gene translation machinery-associated protein 7 pseudogene Neighboring gene lectin, galactose binding, soluble 8 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A mouse translocation associated with Caspr5-2 disruption and perinatal lethality. Weichenhan D, et al. Mamm Genome, 2008 Oct-Dec. PMID 18949514
    2. New members of the neurexin superfamily: multiple rodent homologues of the human CASPR5 gene. Traut W, et al. Mamm Genome, 2006 Jul. PMID 16845472
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    contactin-associated protein like 5-3
    Names
    cell recognition molecule Caspr5-3
    cell recognition molecule Caspr5c
    contactin-associated protein-like 5c

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081653.3 → NP_001075122.1  contactin-associated protein like 5-3 precursor

      See identical proteins and their annotated locations for NP_001075122.1

      Status: VALIDATED

      Source sequence(s)
      AC118684, AC120548, AC122209, AC127557, AC154498, CT025736
      Consensus CDS
      CCDS37671.1
      UniProtKB/Swiss-Prot
      Q0V8T7
      Related
      ENSMUSP00000075416.6, ENSMUST00000076038.7
      Conserved Domains (6) summary
      smart00231
      Location:30 → 174
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      smart00282
      Location:205 → 338
      LamG; Laminin G domain
      cd00054
      Location:960 → 995
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00057
      Location:39 → 173
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd00110
      Location:792 → 936
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam02210
      Location:395 → 521
      Laminin_G_2; Laminin G domain

    RNA

    1. NR_160889.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC120548

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      58076070..58724948
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524744.3 → XP_006524807.1  contactin-associated protein like 5-3 isoform X5

      See identical proteins and their annotated locations for XP_006524807.1

      Conserved Domains (6) summary
      smart00282
      Location:205 → 338
      LamG; Laminin G domain
      cd00054
      Location:961 → 996
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00057
      Location:39 → 173
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd00110
      Location:793 → 937
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:551 → 582
      EGF; EGF-like domain
      pfam02210
      Location:396 → 519
      Laminin_G_2; Laminin G domain

    2. XM_006524747.4 → XP_006524810.1  contactin-associated protein like 5-3 isoform X6

      Conserved Domains (6) summary
      smart00282
      Location:205 → 338
      LamG; Laminin G domain
      cd00054
      Location:961 → 996
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00057
      Location:39 → 173
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd00110
      Location:793 → 937
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:551 → 582
      EGF; EGF-like domain
      pfam02210
      Location:396 → 519
      Laminin_G_2; Laminin G domain

    3. XM_006524750.4 → XP_006524813.1  contactin-associated protein like 5-3 isoform X10

      Conserved Domains (4) summary
      smart00282
      Location:205 → 338
      LamG; Laminin G domain
      cd00057
      Location:39 → 173
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      pfam00008
      Location:551 → 582
      EGF; EGF-like domain
      pfam02210
      Location:396 → 519
      Laminin_G_2; Laminin G domain

    4. XM_006524748.4 → XP_006524811.1  contactin-associated protein like 5-3 isoform X7

      Conserved Domains (5) summary
      smart00282
      Location:205 → 338
      LamG; Laminin G domain
      cd00057
      Location:39 → 173
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd00110
      Location:793 → 890
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:551 → 582
      EGF; EGF-like domain
      pfam02210
      Location:396 → 519
      Laminin_G_2; Laminin G domain

    5. XM_006524749.4 → XP_006524812.1  contactin-associated protein like 5-3 isoform X9

      Conserved Domains (4) summary
      smart00282
      Location:205 → 338
      LamG; Laminin G domain
      cd00057
      Location:39 → 173
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      pfam00008
      Location:551 → 582
      EGF; EGF-like domain
      pfam02210
      Location:396 → 519
      Laminin_G_2; Laminin G domain

    6. XM_006524741.4 → XP_006524804.1  contactin-associated protein like 5-3 isoform X1

      Conserved Domains (6) summary
      smart00282
      Location:205 → 338
      LamG; Laminin G domain
      cd00054
      Location:961 → 996
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00057
      Location:39 → 173
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd00110
      Location:793 → 937
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:551 → 582
      EGF; EGF-like domain
      pfam02210
      Location:396 → 519
      Laminin_G_2; Laminin G domain

    7. XM_006524742.5 → XP_006524805.1  contactin-associated protein like 5-3 isoform X2

      Conserved Domains (5) summary
      cd00054
      Location:913 → 948
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00057
      Location:39 → 173
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd00110
      Location:745 → 889
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:503 → 534
      EGF; EGF-like domain
      pfam02210
      Location:348 → 471
      Laminin_G_2; Laminin G domain

    8. XM_030249937.2 → XP_030105797.1  contactin-associated protein like 5-3 isoform X4

      Conserved Domains (6) summary
      smart00282
      Location:73 → 206
      LamG; Laminin G domain
      cd00054
      Location:829 → 864
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:661 → 805
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cl25480
      Location:2 → 42
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      pfam00008
      Location:419 → 450
      EGF; EGF-like domain
      pfam02210
      Location:264 → 387
      Laminin_G_2; Laminin G domain

    9. XM_036160717.1 → XP_036016610.1  contactin-associated protein like 5-3 isoform X8

      Conserved Domains (4) summary
      cd00054
      Location:512 → 547
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:344 → 488
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:102 → 133
      EGF; EGF-like domain
      pfam02210
      Location:596 → 724
      Laminin_G_2; Laminin G domain

    10. XM_017317594.3 → XP_017173083.1  contactin-associated protein like 5-3 isoform X11

      Conserved Domains (3) summary
      cd00054
      Location:331 → 366
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:163 → 307
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam02210
      Location:415 → 540
      Laminin_G_2; Laminin G domain

    11. XM_011246557.4 → XP_011244859.1  contactin-associated protein like 5-3 isoform X3

      Conserved Domains (6) summary
      smart00282
      Location:144 → 277
      LamG; Laminin G domain
      cd00054
      Location:900 → 935
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00057
      Location:2 → 112
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd00110
      Location:732 → 876
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:490 → 521
      EGF; EGF-like domain
      pfam02210
      Location:335 → 458
      Laminin_G_2; Laminin G domain

    RNA

    1. XR_385354.3 RNA Sequence

    2. XR_385355.4 RNA Sequence

    3. XR_385356.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0V8T7.1 GenPept UniProtKB/Swiss-Prot:Q0V8T7

    Gene LinkOut

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